166 research outputs found
Un nuovo busto loricato di Settimio Severo
No full textThe article publishes for the first time a loricate marble bust, unearthed in clandestine excavations and subject to illicit traffic, which was recovered by the Guardia di Finanza in December 2017 in Rome, Piazza Esedra. The loricate bust depicts Septimius Severus and enriches the knowledge of the fourth type of portraits of the emperor: in addition to a new list of replicas, the author also discusses the occasion and function of the archetype
Frammenti del fregio nord del Partenone
No full textIl contributo esamina i frammenti del fregio nord del Partenone, giunti forse a Venezia dopo le spoliazioni del tempio seguite alladevastazione causata dal doge Francesco Morosini nel 1687.
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Atena Parthenos
No full textL'articolo ricostruisce l'aspetto della Atena Parthenos attraverso le sue riproduzione e ne esamina le vicende nel tempo, dalla dedica sino alla trasformazione del tempio in chiesa
Monitoring fibrosis of the pancreatic remnant after a pancreaticoduodenectomy with dynamic MRI: are the results independent of the adopted reconstructive technique?
No full textNot availabl
La bellezza di Fidia a Roma
No full textL'articolo esamina la ricezione dlle figura di Fidia a Roma, sia nella tradizione letteraria latina sia nel campo delle opere dello scultore (o presunte tali) trasferite nell'Urbe
Gemma di Aspasios
No full textIl contributo esamina la gemma di Aspasios al Museo Nazionale Romano e la sua importanza per la conoscenza dell'aspetto della Atena Partheno
Some computations on the characteristic variety of a line arrangement
No full textWe find monodromy formulas for line arrangements that are fibered with respect to the projection from one point. We use them to find 0-dimensional translated components in the first characteristic variety of the arrangement [InlineEquation not available: see fulltext.] determined by a regular n-polygon and its diagonals. We also find new 1-dimensional translated components which generalize the well-known case of the B3-deleted arrangement. © 2020, The Author(s)
Posttrial corticosterone administration enhances the effects of incentive downshift: Exploring the boundaries of this effect
No full textPosttrial administration of corticosterone was previously shown to enhance consummatory successive negative contrast (cSNC) in rats. The present series of experiments provides additional information that helps determine the boundaries of this effect. Posttrial corticosterone administration (1) enhances cSNC when rats experience a large downshift (32% to 4% sucrose), but not after a small downshift (8% to 4% sucrose; Experiment 1); (2) has no effect in an anticipatory negative contrast situation in which 4% sucrose precedes 32% sucrose in daily trials (Experiment 2); (3) does not support the development of a conditioned taste aversion to 4% sucrose, in the absence of an incentive downshift (Experiment 3); and (4) facilitates the extinction of consummatory behavior (Experiment 4). These results suggest that corticosterone facilitates the encoding of an egocentric aversive memory of the incentive downshift experience.Fil: Ruetti, Eliana Martha. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Justel, Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Mustaca, Alba Elisabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Papini, Mauricio Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentin
Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
No full textMetformin is a widely employed drug in type 2 diabetes. In addition to warranting good short- and long-term glycemic control, metformin displays many intriguing properties as protection against cardiovascular and neurodegenerative diseases, anti-tumorigenic and longevity promotion. In addition to being a low-cost drug, metformin is generally well tolerated. However, despite the enthusiastic drive to aliment these novel studies, many contradictory results suggest the importance of better elucidating the complexity of metformin action in different tissues/cells to establish its possible employment in neurodegenerative diseases. This review summarises recent data identifying lysosomal-dependent processes and lysosomal targets, such as endosomal Na+/H+ exchangers, presenilin enhancer 2 (PEN2), the lysosomal pathway leading to AMP-activated protein kinase (AMPK) activation, and the transcription factor EB (TFEB), modulated by metformin. Lysosomal dysfunctions resulting in autophagic and lysosomal acidification and biogenesis impairment appear to be hallmarks of many inherited and acquired neurodegenerative diseases. Lysosomes are not yet seen as a sort of cellular dump but are crucial in determining key signalling paths and processes involved in the clearance of aggregated proteins. Thus, the possibility of pharmacologically modulating them deserves great interest. Despite the potentiality of metformin in this context, many additional important issues, such as dosing, should be addressed in the future
Giovanni Papini ve "Tükenmiş Adam" adlı yapıt
No full textGiovanni Papini yaşadığı dönem değerlendirildiğinde yenilikçi bir görüşe sahip düşünür olmakla birlikte, entelektüellere, ülkesine ve diğer toplumlara insanlığın içinde bulunduğu çöküşten kurtulabilmesi için liderlik edebileceğine inanan bir düşünürdür. İtalyan yazar dönemin entelektüel çevreleriyle yakın ilişkiler kurar ve onlarla birçok dergi çalışmasında işbirliği yapar. Bunun sonucunda, ortaya pek çok alanda bilgi sahibi ve fikirlerini topluma açıklayan bir düşünür çıkar. Ayrıca, fikirlerini kendisinin de kurucuları arasında bulunduğu dergilerde yayınlayarak İtalya'daki düşünce dünyasına yön veren kişilerden biri olur. Papini Tükenmiş Adam adlı yapıtında ortaya koyduğu düşüncelerle kendi içinde yaşadığı iç çatışmayı ortaya koyar. Bu çatışma, Sanayi Devrimi yaşandıktan sonra özellikle Avrupa toplumlarında yaşam ve çalışma şartlarının değişmesiyle ortaya çıkan ruhsal çöküntüden kaynaklanmaktadır. Yazarın yaşamında karşılaştığı sıkıntılar onun lider olma hedefine ulaşabilmesi hususunda engel olmamasına rağmen, otuz iki yaşında otobiyografisini yazdığı eserinde hayallerine asla ulaşamayacağını itiraf etmiştir. Lakin yine de içindeki öğrenme aşkı ve insanoğluna liderlik etme isteği tam anlamıyla sonlanmamıştır. Bu özelliği ile yaşadığı yılların mücadeleci insan modeline örnek oluşturmuştur. Tükenmiş Adam adlı eser yalnızca yazarı ve çağın insanını anlatmaz, aynı zamanda bir dönemin sosyolojik çözümlemesini de içinde barındırır. Bu yönüyle yapıt XX. yüzyıl yaşam biçiminin, teknolojik gelişmelerinin insanlar üzerindeki etkisini yansıtabilmiştir. Yazar, Tükenmiş Adam adlı eserde daha önce imparatorluklara, devletlere yön vermiş komutanlara ve liderlere ve edebiyat ve düşünce alanında çığır açmış tüm büyüklere öykünerek kendisinin de onlar gibi olacağını hayal etmiştir. Bu ideale ulaşmak için yoğun çaba göstermiştir. Sonuç olarak, İtalyan düşünürün çabaları olmak istediği yere gelebilmesi için yeterli olamasa da, gerek düşünceleri gerek eserleriyle ölümsüz olmayı başarabilmiştir.AbstractWhen the period Giovanni Papini lived in evaluated, he is a modern philosopher as well as a thinker believing that he could lead the intellectuals, his country and other societies in order to save them from the downfall in which humanity was. Italian writer establishes close relationships with the intellectual environment of the period and cooperates with them in lots of works of magazines. Consequently, a thinker, who has knowledge of lots of fields and expresses his thoughts to the society, emerges. Besides, by publishing his thoughts in the magazines among which he is one of the founders, he becomes one of the people dominating over the world of thoughts in Italy. In his work named "The Failure", Papini sets forth his own inner conflict through the ideas he puts forward. This conflict is caused by the psychological collapse emerging with the change of working and living conditions in especially European societies after "the Industrial Revolution". Although the trials and tribulations the author experienced were not obstacles for him in respect of reaching his aims, he confessed that he would never be able to reach his dreams in his work which he wrote his autobiography at the age of thirty-two. Nevertheless, his love of learning and will of leading humanity never ended up. With this characteristic, he became a challenging human model of the time he lived in. His work, "The Failure", does not only tell about the writer and his contemporaries but also includes the sociological analysis of a period. On that sense, the work could reflect the impact of the 20th century life-style and the technological developments on the people. In "The Failure", by emulating the pioneers in the field of literature and thought, leaders and commanders who leaded empires and governments, he imagined that he would be one of them, too. He strived to reach this ideal. As a result, he achieved to become immortal both with his ideas and his works even though the efforts of the Italian thinker were not enough to reach the position he aimed to reach
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