1,721,004 research outputs found
Curcumin and Liver Disease: from Chemistry to Medicine
No full textCurcumin, the natural yellow-colored active principle, also called turmeric yellow, extracted from the perennial
herb Curcuma longa L., has potent biological and pharmacological properties such as antioxidant, anti-inflammatory,
antifungal, antibacterial, anti-ischemic, antitumor, and anticancer actions. The molecular mechanism of the hepatoprotective
action of curcumin is due to its antioxidant properties and inhibitory activity against nuclear factor (NF)-κB that
regulates different proinflammatory and profibrotic cytokines. Overall, scientific reports demonstrate that curcumin has
high therapeutic ability for treating hepatic disorders. Here is a systematic discussion of the hepatoprotective activity of
curcumin and its possible mechanisms of actions
The evidence of health benefits and food applications of Thymus vulgaris L
No full textBackground: T. vulgaris, commonly known as the thyme, is an aromatic plant belonging to the Lauraceae family. Six different chemotypes were described for T. vulgaris. The chemotypes are named after its dominant monoterpene: geraniol (G), a-terpineol (A), thuyanol-4 (U), linalool (L), carvacrol (C), and thymol (T).Scope and approach: For this review, an extensive bibliographic research on Thymus vulgaris was carried out, including its main components both nutrients and bioactives. Botanical description, distribution and cultivation were also addressed as well as uses in folk medicine. Particular attention was given to biological activities, clinical studies, possible limitations and potential applications.Key findings and conclusions: T. vulgaris L. is used as food and for medicinal purposes and it has a great economic importance due to its composition on monoterpene derivatives including p-cymene, thymol and carvacrol. The value of T. vulgaris has been recognized by the pharmaceutical industry, because it proved to have hepatoprotective properties and to have effectiveness as expectorant agent, anti-acne agent, and as fungicidal and antiviral drug. It has been also recognized by the industries of pests' repellents, foods, food packaging and cosmetics. This vast number of industrial applications is mainly due to its antioxidant, antimicrobial, anti-inflammatory and anticancer effects
Green tea (Camellia sinensis L.) as functional beverage: a role in post-stroke depression.
No full textBehavioral effects of 2,3-dihydro- and oxoisoaporphine derivatives in post stroke-depressive like behavior in male BALB/c mice.
No full textIn this study, antidepressant-like effects of intra-cerebroventricularly administration of oxoisoaporphine derivatives in post stroke-depressive like behavior were examined through despair swimming and tail suspension models. For this aim, acute ischemic stroke was induced by bilateral common carotid arteries occlusion which significantly changed the normal behaviors of male balb/c mice. We performed stroke-induced anhedonia test as a key result of post strokedepressive like behavior by determination of sucrose consumption. Results show that some 2,3-dihydro- and oxoisoaporphine derivatives modified the abnormality in the behaviors through decreasing in the immobility time in tail suspension and despair swimming models and increasing in the swimming and climbing times in despair swimming model. We concluded that these alkaloids showed antidepressant actions and therefore can be used for treatment of post strokedepressive like behavior in acute ischemic stroke patient
How much should LDL cholesterol be lowered in secondary prevention? Clinical efficacy and safety in the era of PCSK9 inhibitors
No full textThere is a strong evidence that more marked lowering of low-density lipoprotein cholesterol (LDL-C) leads to progressively lower risk of cardiovascular disease (CVD) events. The evidence on validity of this hypothesis comes from epidemiological, genetic and clinical studies. The hypothesis "the lower the better" has been recently strongly supported by the results of secondary prevention trials with PCSK9 inhibitors. The combination of PCSK9 inhibitors and statins has resulted in achieving extremely low LDL-C levels with additional reduction of CVD events in secondary prevention. However, despite large clinical benefits, the safety of aggressive LDL-C lowering should be always taken into consideration, and there is still an ongoing discussion on whether very low LDL-C might result in some non-CVD adverse events. However, based on the available knowledge, so far the serious adverse events associated with achieving of very low LDL-C levels or intensive drug therapy have not been noted. These positive clinical effects were reflected in current ESC/EAS Guidelines (2019) for dyslipidaemia management. The experts strongly recommended the LDL-C lowering to levels that have been achieved in trials of PCSK9 inhibitors. In this state of the art review, we aimed to finally justify the critical need for LDL-C reduction to very low levels in secondary prevention patients in order to be as low as possible, as early as possible, and preferably lifelong
PROTECTIVE EFFECT OF METHYL 3-O-METHYL GALLATE AGAINST SODIUM FLUORIDE-INDUCED OXIDATIVE STRESS IN RAT CARDIAC TISSUES
No full textMethyl 3-O-methyl gallate (M3OMG), a naturally-occurring compound of
limited distribution, can be readily synthesized from methyl gallate. In the present
study, the protective effect of M3OMG of synthetic origin on fluoride-induced
cardiotoxicity and oxidative stress in cardiac tissues of rats was evaluated. After
intraperitonial administration of M3OMG (10 and 20 mg/kg bw), or the positive control
(ascorbic acid at 10 mg/kg bw), for seven consecutive days, rats were intoxicated by
fluoride (F) with sodium fluoride (NaF) at 600 ppm in their drinking water for a further
week. The level of thiobarbituric acid reactive substances (TBARS) and reduced
glutathione (GSH) and the activities of the antioxidant enzymes superoxide
dismutase (SOD) and catalase (CAT) were examined in the cardiac homogenates. The
results showed that F intoxication caused a significant abnormality in the levels of
TBARS and GSH as well as in the activities of antioxidant enzymes in cardiac tissues.
M3OMG at the dose of at 20 mg/kg bw significantly suppressed the NaF-induced
enhanced level of TBARS. M3OMG also restored the NaF-induced abnormality in the
activities of SOD and CAT and the level of GSH in cardiac tissues. Ascorbic acid
(vitamin C) at 10 mg/kg bw also showed a comparable amelioration of the NaFinduced
toxicity in the rat heart. Taking all the results together, M3OMG demonstrated
a notable cardioprotective role against NaF-induced toxicity and oxidative stress in
rat cardiac tissues
Maqui (Aristotelia chilensis (Molina) Stuntz): in vivo antioxidant activity and antidepressive-like effect of a chemicaly characterized Maqui berry extyract.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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