45,585 research outputs found
Hui tu zhen ben jing shi mu yu jin gang zuan
No full text著作者余好辯, 伍憤時.Cover title.上下卷.On double leaves, East Asian binding.木魚歌文.zhu zuo zhe Yu Haobian, Wu Fenshi.Shang xia juan.Mu yu ge wen
Chao cai liao yong yu ya bo chang ju jiao: ge xiang yi xing hao sun cai liao yu ti du guang xue na mi bo dao guan
No full textKwok, Hui Kin = 超材料用於亞波長聚焦 : 各向異性耗損材料與梯度光學納米波導管 / 郭栩健.Thesis M.Phil. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 67-69).Abstracts also in Chinese.Title from PDF title page (viewed on 26, September, 2016).Kwok, Hui Kin = Chao cai liao yong yu ya bo chang ju jiao : ge xiang yi xing hao sun cai liao yu ti du guang xue na mi bo dao guan / Guo Xujian
Yu Na Lim
No full text학위논문(박사)--아주대학교 일반대학원 :에너지시스템학과,2017. 2Part 1. Utilization of CO and CO2 as C1 Sources: Synthesis of Carboxylic Acids, Organic carbonates and Polyketones 1
Chapter 1. Background of metal-catalyzed carbonylation / carboxylation of alkenes and alkynes. 2
1.1. Palladium-catalyzed carbonylation of alkenes and alkynes. 2
1.1.1. Introduction 2
1.1.2. Hydroxycarbonylation/hydroesterification of alkenes and alkynes. 2
A. Hydroxycarbonylation of alkenes 2
B. Hydroesterification of alkenes 7
C. Hydroesterification of alkynes 11
1.1.3. Oxidative carbonylation of alkenes and alkynes 15
A. Oxidative carbonylation of alkenes 15
B. Oxidative carbonylation of alkynes 19
1.1.4. Summary 22
1.2. Metal-catalyzed carboxylation of alkenes and alkynes 23
1.2.1. Introduction 23
1.2.2. Hydrocarboxylation of alkenes/alkynes 23
A. Hydrocarboxylation of alkenes. 23
B. Hydrocarboxylation of alkynes 25
1.2.3. Direct carboxylation of alkynes 27
A. Carboxylative coupling of alkynes and alkyl halide. 27
B. Direct carboxylation of terminal alkynes. 29
1.2.4. Summary 32
1.3. References 33
Chapter 2. Pd-catalyzed polymerization of CO and olefins. 36
2.1. Introduction 36
2.2. Development of process for synthesizing antifouling polyketones. 39
2.2.1. Result and discussion. 39
A. Synthesis of polyketones using HMON-SO3H, 1.8μm-SiO2-SO3H and PS-SO3H as co-catalyst 39
B. Plausible mechanism. 45
2.2.2. Conclusions. 46
2.3. Thermal property controlled polyketones: terpolymerization of ethylene, alkynes and CO. 47
2.3.1. Result and discussion 47
2.3.2. Conclusions 52
2.4. References 53
Chapter 3. Synthesis of various organic carbonates and carboxylic acids using CO2 54
3.1. Introduction 54
3.2. Synthesis of acyclic and cyclic carbonate using alcohols. 57
3.2.1. Result and discussion 57
3.2.2. Conclusions 63
3.3. Synthesis of Acyclic carbonate with CO2 derivative (Cs2CO3). 64
3.3.1. Result and discussion 64
3.3.2. Conclusions 68
3.4. Metal-free direct carboxylation of acetylene derivatives 69
3.4.1. Result and discussion 69
3.4.2. Conclusions. 73
3.5. References 74
Part 2. Experimental Section 76
Chapter 2. Pd-catalyzed polymerization of CO and olefins. 77
2.2. Development of process for synthesizing antifouling polyketones. 77
2.3. Thermal property controlled polyketones: terpolymerization of ethylene, alkynes and CO. 81
Chapter 3. Synthesis of various organic carbonates and carboxylic acids using CO2. 90
3.2. Synthesis of acyclic and cyclic carbonate using alcohols. 90
A. Synthesis of 14a 90
B. Synthesis of 18O-labeled 12a 91
3.3. Synthesis of Acyclic carbonate with CO2 derivative (Cs2CO3). 102
3.4. Metal-free direct carboxylation of acetylene derivatives 106DoctoralGreenhouse gas (GHG) generated in the use of fossil fuels that is not consumed naturally in the atmosphere and caused by the human race has resulted in global warming. GHGs generally include carbon dioxide (CO2), methane (CH4), carbon monoxide (CO), nitrogen dioxide (NO2), hydrofluorocarbons (HFCS), and perfluorocarbons (PFC), etc. The utilization of C1 gas like carbon monoxide, carbon dioxide, and, methane as chemical feedstock can be the solution to global warming. I have presented the chemical conversion of CO and CO2 as a C1 source in this thesis.
In Chapter 1, the metal-catalyzed carbonyl/carboxylation of alkene and alkynes reaction have been reviewed overall. Typically, catalysts such as Pd, Ru, and Ni are known as an active catalyst for carbonylation. In particular, Pd catalysts have been successfully used for the synthesis of carboxylic acid and carboxylic acid esters from alkene and alkynes. Thus, in the first section of Chapter 1, I reviewed Pd-catalyzed carbonylation of alkenes and alkynes from CO. On the other hand, in the second section of Chapter 1, I reviewed the metal-catalyzed carboxylation of alkene and alkyne from CO2. The carbonation of CO2 was different from the carbonylation of CO, with the reaction acting according to the metal catalysts acting on the reaction different from each other. The Ni catalyst mainly induces hydrocarbonylation and the Cu or Ag catalyst induces a direct coupling reaction.
In Chapter 2, a Pd catalyst was used to polymerize CO and ethylene. The co-polymers of CO and ethylene, called polyketone, can be used for the same industrial materials used in automotive and electronics as polymers with high impact strength, chemical resistance, flame retardancy, and so on. However, polyketones had the problem of having a "reactor fouling" (disturbed formation of some of the polymer particles attached to the reactor wall and the agitator) and a high melting point (over 250 oC). In this study, we have developed polyketones without reactor fouling by using sulfonated HMON, silica, and polystyrene as heterogonous catalysts. Terpolymerization was performed to add a phenyl acetylene derivative to reduce meting point.
In Chapter 3, the synthesis of the transition metal-free organic carbonates and carboxylic acid was carried out using a CO2 and CO2 derivative (Cs2CO3). The CO2 required vigorous reaction condition using an organometallic catalyst for activating CO2 due to its high thermo-dynamic and kinetic safety. In this research, we developed an environmentally-friendly CO2 activation process with a mild condition that uses a transition metal free method and uses CO2 as low pressure. We used TBD and DBU for CO2 activation and synthesized various organic carbonates by advancing CO2 direct coupling to alcohol. Also, carboxylic acid was synthesized through direct CO2 coupling to acetylene derivatives using TBD
YU NA JO
No full text학위논문(석사)--아주대학교 일반대학원 :의생명과학과,2015. 2위암 (Gastric cancer) 은 매년 전세계에서 암 사망률의 주요 원인 중 하나이다. 위암과 관련된 여러 가지 새로운 종양 유전자와 종양 억제 유전자를 찾는 것은 조기 진단과 표적 치료의 발전을 위해 도움이 될 수 있다. 그 중 Poly (ADP-ribose) polymerase1 (PARP1) 은 많은 암 종류에서 항암치료의 타겟으로 보고되어 왔으며 PARP1억제제를 이용한 임상시험이 다양한 암 종을 바탕으로 진행되었으며 현재까지 수행되고 있다. 하지만, PARP1을 저해하게 되면 종양 발달이 어떻게 억제가 되는지 충분히 설명되어지지 않고 있다. 따라서, 위암 세포를 이용하여 PARP1 저해제인 올라파립 (Olaparib) 뿐만 아니라 PARP1 siRNA를 가지고 PARP1의 저해가 암세포의 성장을 어떻게 조절하는지를 보여주었으며 PARP1저해에 의한 FOXO3의 발현 증가를 통해 종양을 억제하는 효과를 가져온다. 뿐만 아니라, 166개의 tumor stage-matched 위암 환자 샘플을 사용하여 PARP1과 FOXO3 발현을 조직 마이크로 어레이로 평가하였다. 다변량 분석을 통해 PARP1 및 FOXO3 의 발현 차이에 따른 생존 곡선을 비교한 결과, 전체 생존 기간 (overall survival, PARP1; P = 0.021, FOXO3; P = 0.001) 및 무 재발 생존 기간 (relapse-free survival, PARP1; P = 0.021, FOXO3; P = 0.001) 의 영향을 주는 요인으로써 암의 독립적인 예후 지표로 활용 가능하다는 것을 확인하였다. 결론적으로, 우리의 결과는 PARP1- FOXO3 신호는 임상적인 의미와 암세포의 성장에 중요한 역할을 한다는 것을 입증하였고, 이는 암 치료에 있어 PARP1-FOXO3신호는 새로운 메커니즘과 임상 통찰력을 제안 할 수 있다.차 례
국문요약 ⅰ
차례 ⅲ
그림 차례 ⅴ
표 차례 ⅵ
Ⅰ. 서론 1
Ⅱ. 재료 및 방법 7
A. 위암세포 배양 7
B. 약물처리 7
C. siRNA Transfection 8
D. MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylteteazolium bromide)assay 8
E. Cell counting 8
F. Colony forming assay 9
G. Western blotting 9
H. 환자 및 표본 10
I. Tissue microarray 11
J. RNA 분리 및 real-time PCR 12
K. 통계처리 13
Ⅲ. 결과 15
A. 위암 세포에서 PARP1의 억제의 세포 성장 억제 15
B. PAPR1의 억제는 FOXO3의 발현 유도 19
C. PARP1과 FOXO3의 발현과 위암 환자 임상결과 2 1
D. PARP1과 FOXO3 발현은 위암 환자의 생존율에 영향 32
Ⅳ. 고찰 38
Ⅴ. 결론 44
참고문헌 45
ABSTRACT 56Maste
Fabaeformiscandona subacuta Ma & Yu 2018
No full textFabaeformiscandona subacuta (Yang, 1982, in Hou et al., 1982) (Figures 4a–c, 5) Candona (Candona) subacuta Yang Hou et al., 1982: 71, pl. 17, figs. 3–5. Candona japonica sp. nov. Okubo, 1990, 40–42, fig. 1(j–r). Fabaeformiscandona japonica comb. nov. Schornikov and Trebukhova, 2001: 64. Fabaeformiscandona subacuta comb. nov. Schornikov, 2004: 458–465. Material examined Three females (ECNU20140907/TT23, 25; ECNU20150419/TT42) and three males (ECNU20140907/TT24; ECNU20150419/TT48; ECNU20150418/TT49) dissected. Dimensions (Female, n = 3) Length, 0.96–1.06 mm; height, 0.48–0.50 mm; width, 0.41 mm. (Male, n = 3) Length, 1.13–1.18 mm; height, 0.58–0.60 mm. Brief description Female, height of carapace equal to half of length. In dorsal view, LV overlapping RV with flanges both anteriorly and posteriorly. Two setae present on the end of first endopodal segment of A2. The penultimate segment of L7 divided. Claw Gp on UR equalling threequarters the length of claw Ga. Seta Sa small. More than two branches present on UR attachment. Male, right palp of L5 large (Figure 5a). Left palp L-shaped with distal indentation (Figure 5b). Zenker organ with seven rows of chitinized rosettes. Outer lobe on Hp distally pointed (Figure 5d). Distribution This species is globally widespread and is thought to have originated in Asia (Escrivà et al. 2012). In China, living examples of F. subacuta have been reported from Beijing (Zhai et al. 2017), Zhejiang (Escrivà et al. 2012) and Guizhou (Kong et al. 2013).Published as part of Ma, Shunxin & Yu, Na, 2018, Freshwater ostracods (Crustacea) from Tiantong National Forest Park and Dongqian Lake, eastern China, with descriptions of two new species, pp. 1825-1868 in Journal of Natural History 52 (27 - 28) on page 1832, DOI: 10.1080/00222933.2018.1489085, http://zenodo.org/record/517515
A study on vision sensors for seam tracking of height-varying weldment. Part 1: Mathematical model
No full textAmong the various types of sensors used in welding automation, are and vision sensors are widely used for automatic seam tracking and quality control of are welding processes. The development of a vision sensor which can provide 3D geometry information is needed especially for robot guidance in automatic welding of thin plates, because it is difficult to apply an are sensor to the welding of thin plates. Vision sensors using optical triangulation have been widely used in various ways for automatic welding systems. The separation angle between the camera and the laser axis has been mainly considered in previous studies of the vision sensor with structured light. Their measuring efficiency is, however, considerably influenced by the different arrangements of the weldment, the CCD camera, and a diode laser of a vision sensor in three-dimensional space. Therefore to enhance the effectiveness of a vision sensor for height-varying workpieces, other geometrical parameters such as diagonal and tilt angles should also be investigated. In the present study, the data deficiency in the vision sensor falls into two classifications: the shadow effect and the missing field of view (FOV), and a mathematical model is proposed to estimate the occurrence of data deficiency. (C) 1997 Elsevier Science Ltd
A study on vision sensors for seam tracking of height-varying weldment. Part 2: Applications
No full textMany efforts have been made to develop an automatic welding system in order to improve the quality and productivity in welding shipping containers and LNG (Liquefied Natural Gas) storage tanks which consist of many sheet metals having linear weldments with height variation. A vision sensor which can provide 3D geometry information about objects is investigated primarily, because it is difficult to apply the are sensor to automatic welding of thin plates. However it is difficult to determine the proper configuration of sensory system including a CCD camera and diode laser to specific weldments because of the interference and relative motion among vision sensor, welding torch and weldment. Therefore, to develop a vision sensor with high performance for a specific workpiece, the sensory system should be analyzed for various configurations of sensors and weldment shapes by using a mathematical model. In this study, the measuring efficiency of vision sensor predicted by its model and the criterion for data deficiency was in significant agreement with experiments for typical corrugations of shipping containers and LNG tanks. It was found that the results obtained from the mathematical model were very useful in designing the vision sensor for automatic welding of linear weldments with height variation. (C) 1998 Elsevier Science Ltd
DILOF: Effective and Memory Efficient Local Outlier Detection in Data Streams
No full textWith precipitously growing demand to detect outliers in data streams, many studies have been conducted aiming to develop extensions of well-known outlier detection algorithm called Local Outlier Factor (LOF), for data streams. However, existing LOF-based algorithms for data streams still suffer from two inherent limitations: 1) Large amount of memory space is required. 2) A long sequence of outliers is not detected. In this paper, we propose a new outlier detection algorithm for data streams, called DILOF that effectively overcomes the limitations. To this end, we first develop a novel density-based sampling algorithm to summarize past data and then propose a new strategy for detecting a sequence of outliers. It is worth noting that our proposing algorithms do not require any prior knowledge or assumptions on data distribution. Moreover, we accelerate the execution time of DILOF about 15 times by developing a powerful distance approximation technique. Our comprehensive experiments on real-world datasets demonstrate that DILOF significantly outperforms the state-of-the-art competitors in terms of accuracy and execution time. The source code for the proposed algorithm is available at our website: http://di.postech.ac.kr/DILOF.1
Yu Takeuchi
No full textYu Takeuchi is serving for JAXA since 2007 and currently working as Associate Senior Administrator at Management and Integration Department of Human Spaceflight Technology Directorate. He is also working as Researcher at the Institute of Space Law of Keio University. He received LL.M. degree from the Institute of Air and Space Law of McGill University in 2015. His main interest is in international space law inter alia the legal aspects of space traffic management and sustainable space development. He is a member of the Air Law Institute of Japan, Japanese Society of International Law, and the International Institute of Space Law (IISL).
Main Works Published in English
- “Toward the International Regime for Space Traffic Management -What to Fix the Current International Regulations-”, (November 5, 2014). Space Traffic Management Conference, Paper 23 (http://commons.erau.edu/stm/2014/wednesday/23).
- “Regulatory Regime for Tomorrow’s Suborbital Space Flights: Point-to-point International Flights”, 56th Colloquium on the Law of Outer Space, 2013.
- “Space Traffic Management as a Guiding Principle of the International Regime of Sustainable Space Activities,” 4 Journal of East Asia and International Law, 2011
- “Japanese Perspective on Legal Issues of Commercial Human Spaceflight” (co-author), 53rd Colloquium on the Law of Outer Space, 2011
- “Legal Points at Issue about NEO Threat Response and International Cooperation” (co-author), 28th International Symposium on Space Technology and Science, 2011
- “From Guideline to International Treaty for Rule of Law concerning Mitigation of Space Debris?” (co-author), 52nd Colloquium on the Law of Outer Space, 2010
Main Works Published in Japanese (title translated into English)
- “What is Space Traffic Management”, Vol. 46, No.9, Journal of the Japanese Institute of International Business Law, 2018.
- Soichiro Kozuka & Masahiko Sato eds., Introduction of Space Law for Entrepreneur (2nd. Ed.), Yuhikaku, 2018. (co-authored)
-“Challenges to International Space Law for Managing Space Traffic”, 55 Kuho (Air Law), 2014.
-“Legal Points as Issues of NEO Threat Response and International Cooperation” (co-author), 3 Spaceguard Research, Japan Spaceguard Association, 2011https://commons.erau.edu/stm-images/1121/thumbnail.jp
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