1,720,972 research outputs found
A 19 year follow-up of a woman with lipoprotein lipase deficiency treated with biliopancreatic diversion
No full textWe show the long-term efficacy and safety of modified biliopancreatic diversion for the treatment of LPL-deficiency. How this option compares with gene therapy is difficult to evaluate due to limited experience. Surgery may be the first option in patients in whom medical therapy is ineffective and gene therapy not applicable
Gestione dietetico-nutrizionale dei pazienti con diabete tipo 2 e obesità sottoposti a interventi di chirurgia bariatrica
No full textRole of the Entero-Insular Axis in the Pathogenesis of Idiopathic Reactive Hypoglycemia: A Pilot Study
No full textIdiopathic reactive hypoglycemia (IRH) is characterized by recurrent episodes of symptomatic hypoglycemia occurring within 4 hours after meals. The underlying mechanisms remain obscure
Five-year results of laparoscopic sleeve gastrectomy: Effects on gastroesophageal reflux disease symptoms and co-morbidities
No full textAbstract
BACKGROUND:
Laparoscopic sleeve gastrectomy (LSG) is becoming the most performed bariatric procedure; however, data available on long-term follow-up are scanty.
OBJECTIVES:
The aim of the present study was to evaluate the 5-year efficacy of LSG on weight loss, gastroesophageal reflux disease (GERD) symptoms, and obesity-associated co-morbidities.
SETTING:
Tertiary-care referral hospital.
METHODS:
This study retrospectively analyzed 105 obese patients undergoing LSG from January 2006 to December 2009. The preoperative evaluation included demographic characteristics, evaluation of co-morbidities, a double-contrast barium swallow, and an upper-gastrointestinal endoscopy. The following data were collected at 1, 3, and 5 years after surgery: weight, improvement/remission of co-morbidities, complications, and revisional surgery.
RESULTS:
According to preoperative body mass index (BMI), patients were divided into Group 1 (n = 61) with BMI≤50 kg/m(2) and Group 2 (n = 44) with BMI>50 kg/m(2). The follow-up rate was 94% after 5 years (n = 99). Delta BMI (BMI at follow-up-preoperative BMI) was significantly higher in Group 2 than in Group 1 at 1-3 years and 5 years (P<.001). Furthermore, at 5 years, Group 2 showed a significantly higher percentage total weight loss (%TWL) (26.6%±18.3% versus 33.5%±12.9%, P = .006) than Group 1, whereas percentage excess weight loss was similar (58.4%±21.8% versus 55.3%±19.5%, P = .5).Younger age at surgery and absence of postoperative GERD were associated with a better %TWL at 5 years (P<.001 and P = .03).
CONCLUSION:
LSG is an effective procedure at long-term, with good weight loss outcomes and with a considerable improvement of obesity-associated co-morbidities. Younger age at surgery and absence of postoperative GERD were associated with a better %TWL at 5 years
Effects of Sleeve Gastrectomy and Gastric Bypass on Postprandial Lipid Profile in Obese Type 2 Diabetic Patients: a 2-Year Follow-up
No full textBariatric surgery (BS) is known to favorably impact fasting lipid profile. Fasting and postprandial lipids were evaluated before and 2 years after BS in obese type 2 diabetic (T2DM) patients. Methods A prospective study was conducted in 19 obese T2DM patients: ten undergoing sleeve gastrectomy (SG) and nine undergoing Roux-en-Y gastric bypass (RYGB). Before and 2 years after BS, clinical parameters and the response of lipid and incretin hormones to a mixed meal (MM) were assessed. Results The two groups had similar characteristics at baseline.After BS, weight loss was similar in the two groups (p≤0.01). Fasting glucose, insulin, and triglycerides decreased while HDL cholesterol increased in a similar way (p<0.05); in contrast, fasting LDL cholesterol decreased only after RYGB (p<0.05). Post-meal glucose concentrations decreased while early insulin response significantly improved after both procedures (p<0.001 for both). Postprandial triglycerides decreased after both procedures (p<0.05) while postprandial LDL cholesterol decreased only after RYGB (p<0.05). Meal-GLP-1 increased postoperatively in both groups although to a greater extent after RYGB (p<0.001 vs. SG). GIP decreased after both procedures, especially after RYGB (p=0.003). At multivariate analysis, GLP-1 peak was the best predictor of LDL reduction (β=−0.552, p=0.039) while the improvement of HOMA-IR (β=0.574, p=0.014) and weight loss (β=0.418, p=0.036) predicted triglycerides reduction. Conclusions Both surgical procedures markedly reduce fasting and postprandial triglycerides and increase HDL cholesterol levels. LDL cholesterol decreases only after RYGB through a mechanism likely mediated by the restoration of GLP-1
Studio retrospettivo sull’efficacia a un anno della terapia medica con liraglutide e della chirurgia bariatrica nel trattamento del paziente con diabete di tipo 2 e obesità
No full textClinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation
No full textTo evaluate the clinical efficacy of bariatric surgery vs medical therapy with liraglutide on weight loss, glycemic control and cardiovascular risk profile in patients with type 2 diabetes and severe obesity
- …
