1,721,067 research outputs found
Donatori e riceventi anziani
No full textLa natura dell’evento che ha causato il decesso del potenziale donatore può fornire informazioni importanti sulle condizioni degli organi che dovremo prelevare.
Le cause di morte encefaliche che riguardano donatori anziani rientrano normalmente nelle categorie accidenti cerebrovascolari (ictus o emorragia cerebrale). Altre cause di decesso meno frequenti in questo pool di donatori sono trauma cerebrale che si può verificare ad esempio in seguito ad un incidente domestico ed encefalopatia post-anossica.
In caso di trauma cranico anche altri organi intraddominali potrebbero avere subito dei danni di varia estensione. Oltre a danni meccanici, quali ematomi e lacerazioni, sugli organi intraddominali, si può verificare insufficienza renale da mioglobinuria secondaria a rabdomiolisi massiva
The multiple aspects of liver transplantation for hepatocellular carcinoma: comments on the recommendations from the consensus conference
No full textHepatocellular carcinoma (HCC) is a recognized indication for liver transplantation (LT) as it can at the same time provide a radical oncological resection and prevent its recurrence treating the hepatic disease. However the shortage of donors and the long time on waiting list forces the hepatologists and transplant surgeons to adopt bridging locoregional treatments to prevent the drop out and to perform downstaging treatments to offer a chance of radical intervention to more patients. The therapeutical strategies for patients suffering from HCC are various and different choices should be considered according to each patient's clinical situation according to prognostic and staging systems. Recently recommendations have been published on Lancet Oncology about this topic. These guidelines are very helpful in choosing among the different therapeutic options and in the management of patients in waiting list. Here we briefly summarize and comment the main features covered in the recommendations
Donatori e riceventi di organi nella popolazione geriatrica
No full textLa morte cerebrale viene definita come la cessazione permanente e irreversibile di tutte le funzioni encefaliche ed è regolata dalla legge 578 del 1993. In Italia la donazione di organi e tessuti da donatore in morte cerebrale è consentita e regolamentata dalla legge n. 91 del 1999. Tali normative disciplinano l’accertamento di morte, la formulazione della manifestazione della volontà alla donazione e l’organizzazione del trapianto
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
DNA Methylation - and Telomere - Based Biological Age Estimation as Markers of Biological Aging in Donors Kidneys
Full text linkThe biological age of an organ may represent a valuable tool for assessing its quality, especially in the elder. We examined the biological age of the kidneys [right (RK) and left kidney (LK)] and blood leukocytes in the same subject and compared these to assess whether blood mirrors kidney biological aging. Biological age was studied in n = 36 donors (median age: 72 years, range: 19-92; male: 42%) by exploring mitotic and non-mitotic pathways, using telomere length (TL) and age-methylation changes (DNAmAge) and its acceleration (AgeAcc). RK and LK DNAmAge are older than blood DNAmAge (RK vs. Blood, p = 0.0271 and LK vs. Blood, p = 0.0245) and RK and LK AgeAcc present higher score (this mean the AgeAcc is faster) than that of blood leukocytes (p = 0.0271 and p = 0.0245) in the same donor. TL of RK and LK are instead longer than that of blood (p = 0.0011 and p = 0.0098) and the increase in Remuzzi-Karpinski score is strongly correlated with kidney TL attrition (p = 0.0046). Finally, blood and kidney TL (p < 0.01) and DNAmAge (p < 0.001) were correlated. These markers can be evaluated in further studies as indicators of biological age of donor organ quality and increase the usage of organs from donors of advanced age therefore offering a potential translational research inkidney transplantation
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