1,720,970 research outputs found
Oral amino acids in elderly subjects: Effect on myocardial function and walking capacity
No full textIF 1,3
Detection of coronary artery disease in asymptomatic patients with type 2 diabetes mellitus
No full textWe sought to verify the effectiveness of current American Diabetes Association screening guidelines in identifying asymptomatic patients with coronary artery disease (CAD) in type 2 diabetes mellitus (DM2).
BACKGROUND In DM2 patients, CAD generally is detected in an advanced stage with an extensive atherosclerosis and poor outcome, whereas CAD in an asymptomatic stage is commonly
missed.
METHODS This study included 1,899 asymptomatic DM2 patients (age >60 years). Of these, 1,121 had >2 associated risk factors (RFs), group A, and the remaining 778 had >1 RF, group B, for
CAD. All patients underwent dipyridamole myocardial contrast echocardiography (MCE), and in those with myocardial perfusion defects, the anatomy of coronary vessels was analyzed
by selective coronary angiography.
RESULTS In the two study groups, the prevalence of abnormal MCE (59.4% vs. 60%, p < 0.96) and
of a significant CAD (64.6% vs. 65.5%, p <0.92) was similar, irrespective of RF profile. But coronary anatomy differed: group B had a lower prevalence of three-vessel disease (7.6% vs.
33.3%, p <0.001), of diffuse disease (18.0% vs. 54.9%, p 0.001), and of vessel occlusion (3.8% vs. 31.2%, p <0.001), whereas one-vessel disease was more frequent (70.6% vs. 46.3%, p < 0.001). Coronary anatomy did not allow any revascularization procedure in 45% of group A patients.
CONCLUSIONS An “aggressive” diagnostic approach, requiring coronary angiography in asymptomatic DM2 patients with >1 associated RF for CAD and abnormal MCE, identified patients with a subclinical CAD characterized by a more favorable angiographic anatomy. The criterion of >2 RFs did not help to identify asymptomatic patients with a higher prevalence of CAD and is only related to a more severe CAD with unfavorable coronary anatomy
Postprandial myocardial perfusion in healthy subjects and in type 2 diabetic patients
No full textIF=10.94
Effects of treatment with sulfonylurea drugs or insulin on ischemia-induced myocardial dysfunction in type 2 diabetes
No full textIF 8,2
Abnormal myocardial perfusion and contractile recruitment during exercise in type 1 diabetic patients
No full text
Comparative Investigation of Gamma Radiation Effects on Long Period Gratings and Optical Power in Different Optical Fibers
No full textThis work presents a comparative study regarding the effects of gamma radiation on standard and different radiation hardened optical fibers, by means of arc-induced long period gratings (LPGs) written in these fibers. In particular, the resonance wavelength shift (Δλres) of LPG attenuation bands and the attenuation in the fiber transmitted optical power (ΔP) have been comparatively explored during irradiation. Different responses were observed depending on the fiber model. The Ge-doped fiber exhibits significant changes of both resonance wavelength and optical transmission loss, whereas the pure silica core fiber is mostly insensitive to radiation (Δλres and ΔP keep almost close to zero). Surprisingly, the radiation resistant fiber, with doped core, exhibits significant resonance shift even if with trivial power losses. In addition, by combining these results with numerical modeling of LPGs, we were able to estimate the radiation effects on the optical fibers under investigation, in terms of average refractive index change. These results can be useful for the application of such devices in radiation environments, i.e., for the development of both radiation sensitive and radiation hardened sensors
Early myocardial dysfunction in the diabetic heart: Current research and clinical applications
No full textIimpact factor 3.05
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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