1,720,968 research outputs found
Thin film technology: new opportunity for buccal controlled delivery. MITO. Un viaggio tra liposomi e polisaccaridi-A journey through liposomes and polysaccharides. Ediz. bilingue
No full textManufacturing and characterization of polymeric thin films for buccal delivery of drugs
No full textThis study aimed to explore film forming capacity of a natural
polysaccharide, gellan gum (GG), for fabrication of oral thin films
(OTFs) for the delivery of drugs [1]. For the development of
buccal film with ideal mechanical properties and adequate
amount of drug incorporated, concentration of polymer and
plasticizer were optimized to obtain films with the highest
standard in terms of flexibility and homogeneity [2]. Moreover,
attention was also paid to the exploration of opportune
dissolution tests able to discriminate the release profiles of drugs
from polymeric thin films
Planning sine waves electroporation on liposomes for drug delivery application
No full textRadiofrequency (RF) signals as a way to remotely control smart drug delivery nanocarriers represent a promising tool to overcome traditional therapeutic issues, such as overdosing therapeutic agents with a reduced efficacy and related side effects on healthy tissues, in order to obtain a targeted release near diseased cells. Aim of this work is to provide a deep investigation on the possible effect of sine wave RF signals, of 100 kHz and 10 MHz, applied to a non-uniform random distribution of 142 liposomes, as a realistic model of a biocompatible drug delivery suspension, to study electroporation mechanisms occurring during exposure
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Emerging trends in liposome design. MITO. Un viaggio tra liposomi e polisaccaridi-A journey through liposomes and polysaccharides. Ediz. bilingue
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Magnetoliposomes: envisioning new strategies for water decontamination
Full text linkIn this work, the inclusion of magnetic nanoparticles (MNPs) within phospholipid vesicles has been
investigated as novel strategy for improving stability and reactivity of these nanoparticles and extending their
potential use in the environmental field. Two phospholipids able to form liposomes characterized by different
rigidity and stiffness, were used as potential carriers of MNPs. The magneto-responsive liposomes were
investigated for their physicochemical and stability properties. In particular, the stability of the two systems
was indirectly investigated evaluating the ability of the hybrid constructs to retain a fluorescent marker in their
structure. Alterations in the permeability of the membranes were determined by the rate of the marker release
from the liposomes, under both mechanical and thermal stress conditions
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