17 research outputs found
Retinoblastoma. Part 1. Clinical presentations and diagnostic tools
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Retinoblastoma. Part 1. Clinical presentations and diagnostic tools
S.V. Ivanova1, S.A. Kuleva1, N.N. Sadovnikova2, M.I. Komissarov2, M.N. Chistyakova2,
A.V. Khokhlova1, N.A. Shchegoleva3
1N.N. Petrov National Medical Research Center of Oncology, St. Petersburg,
Russian Federation
2St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation
3K.A. Rauchfuss St. Petersburg Children’s City Multidisciplinary Clinical Center of High Medical Technologies, St. Petersburg, Russian Federation
Retinoblastoma is one of the most common retinal tumors in young children. At the time of primary diagnosis, mean age is no more than 1.5 years. The association between tumor development and the loss of both alleles of RB1 gene is well-established. Mutations in the RB1 gene result in the complete inactivation of retinoblastoma protein expression and, therefore, uncontrolled cell proliferation and generation of tumor cell clone. There are two types of retinoblastoma, i.e., hereditary and sporadic. This paper describes in detail clinical epidemiological characteristics of hereditary and sporadic retinoblastoma and major clinical signs (in particular, one of the most early and common symptoms, leukocoria). Histology of malignant tumor and its benign precursor is addressed. Current classification systems of intraocular retinoblastoma are based on tumor extent being required to specify clear indications for organ preservation treatment. Modern diagnostic tools for retinoblastoma are discussed as well. Eye fundus examination is the gold standard but has some specifics in young children. Other important imaging techniques in retinoblastoma are sonography, optical coherence tomography, and magnetic resonance imaging.
Keywords: children, retinoblastoma, heredity, retinoblastoma gene, pathomorphology, leukocoria, ophthalmoscopy, sonography.
For citation: Ivanova S.V., Kuleva S.A., Sadovnikova N.N. et al. Retinoblastoma. Part 1. Clinical presentations and diagnostic tools. Russian Journal of Clinical Ophthalmology. 2020;20(3):159–164. DOI: 10.32364/2311-7729-2020-20-3-159-164.
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Retinoblastoma. Part 2. Treatment strategies for intraocular retinoblastoma
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S.V. Ivanova1, S.A. Kuleva1, N.N. Sadovnikova2, M.I. Komissarov2, M.N. Chistyakova2,
A.V. Khokhlova1, N.A. Shchegoleva3
1N.N. Petrov National Medical Research Center of Oncology, St. Petersburg,
Russian Federation
2St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation
3K.A. Rauchfuss St. Petersburg Children’s City Multidisciplinary Clinical Center of High Medical Technologies, St. Petersburg, Russian Federation
Retinoblastoma is one of the most common retinal tumors in young children. Current early diagnostic and treatment strategies focus on the possibility to implement eye-preserving therapies. The 5-year overall survival for children with retinoblastoma is now 100%. First-line eye removal is recommended in extensive intraocular seeding and poor visual prognosis. The volume of adjuvant therapy is based on the histological risk factors for disease progression. This paper discusses the algorithms to determine risk factors and further systemic treatment strategy in several large study groups. Eye and even vision preservation is now possible in at least 65–75% of retinoblastoma patients. The paper also describes in detail the methods of locally administering chemotherapy which are considered eye-preserving treatment options, i.e., selective intra-arterial chemotherapy and intravitreal chemotherapy. Various physical methods of eye-preserving treatment which underwent significant deve lopment over the past decade are highlighted. In conclusion, the authors emphasize that retinoblastoma survivors, their siblings and offspring should be carefully monitored.
Keywords: children, retinoblastoma, enucleation, polychemotherapy, selective intra-arterial chemotherapy, intravitreal chemotherapy, laser photocoagulation, transpupillary thermotherapy, cryotherapy, brachytherapy, monitoring.
For citation: Ivanova S.V., Kuleva S.A., Sadovnikova N.N. et al. Retinoblastoma. Part 2. Treatment strategies for intraocular retinoblastoma. Russian Journal of Clinical Ophthalmology. 2020;20(4):197–203. DOI: 10.32364/2311-7729-2020-20-4-197-203.
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The images of "holy wives" in the two "theatrical poems" of Osip Mandelstam
No full textThe author analyzes two “theatrical” poems by Mandelstam written in the 1920s with an especial focus on the use of ancient mythological names, first and foremost those of Cypride and Euridice. The analysis clarifies the semantics of the central image of the poem - the image of 'holy wives' which fuses the features of Boticcelli's Spring and Venus, and also absorbs the reflections of female actresses who had inspired Blok (Nina Volokhova, Vera Shchegoleva, Liubov' Delmas) and also Anna Akhmatova
Effect of the polytwinned microstructure parameters on magnetic domain structure and hysteresis properties of the CoPt-type alloys
No full textThe images of "holy wives" in the two "theatrical poems" of Osip Mandelstam
No full textThe author analyzes two “theatrical” poems by Mandelstam written in the 1920s with an especial focus on the use of ancient mythological names, first and foremost those of Cypride and Euridice. The analysis clarifies the semantics of the central image of the poem - the image of 'holy wives' which fuses the features of Boticcelli's Spring and Venus, and also absorbs the reflections of female actresses who had inspired Blok (Nina Volokhova, Vera Shchegoleva, Liubov' Delmas) and also Anna Akhmatova
Domain structures and polarizable optical effects in polytwinned nanocrystalline alloys of CoPt type
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