3,683 research outputs found
P EN GA R U H KU A LI TA S LA Y A N A N D A N BA U R A N P EM A SA R A N R I TEL TER HA D A P KEP U A SA N D A N LOY A LI TA S P EL A N GGA N P A SA R SOR E M OR O SE N EN G D ESA JAJAG KEC A M A TA N GA M BI R A N BA N Y U WA N GI
No full textP
e
ne
li
ti
a
n
ini
be
rtujua
n
u
ntuk
(1)
menje
laska
n
da
n
meng
a
n
a
li
sis
pe
ng
a
r
uh
kua
li
tas
la
y
a
na
n
ter
h
a
da
p
ke
p
ua
sa
n
konsum
e
n,
(2)
menje
laska
n
da
n
men
ga
na
li
sa
pe
nga
ruh
b
a
ur
a
n
pe
mas
a
ra
n
ritel
te
rha
d
a
p
ke
pu
a
sa
n
konsum
e
n,
(3
)
menj
e
laska
n
menga
na
li
sis
pe
n
g
a
ruh
k
ua
li
tas
la
y
a
na
n
lo
y
a
li
tas
konsum
e
n,
(4)
menje
lask
a
n
da
n
menga
na
li
sa
p
e
n
g
a
ruh
b
a
ur
a
n
p
e
masa
ra
n
ritel
ter
ha
da
p
lo
y
a
li
tas
konsum
e
n
,
se
rta
(5)
menje
laska
n
d
a
n
me
ng
a
n
a
li
sa
pe
n
g
a
ruh
ke
pu
a
sa
n
de
n
ga
n
lo
y
a
li
tas
ko
nsum
e
n
pa
sa
r
so
re
Mo
ro
S
e
n
e
n
g
de
sa
J
a
jag
k
e
c
a
mata
n
Ga
mbi
ra
n
B
a
n
y
u
wa
n
g
i
.
P
opulasi
pe
ne
li
ti
a
n
a
da
lah
konsu
men
pa
sa
r
sore
Mo
ro
S
e
ne
ng
J
a
jag
.
T
e
knik
pe
n
ga
mbi
lan
sa
mpel
a
da
lah
non
probabi
li
ty
sampli
ng
de
ng
a
n
men
gg
un
a
ka
n
pu
rposi
v
e
sampli
ng.
J
uml
a
h
sa
mp
e
l
dit
e
ntukan
y
a
kni
se
b
a
n
y
a
k
180
sa
mpel.
S
e
da
ng
k
a
n
teknik
a
na
li
sis
da
ta
men
gg
una
k
a
n
a
n
a
li
sis
stuctural
e
quati
on
mode
ll
ing
(SEM)
de
nga
n
pr
o
g
r
a
m
AMO
S
16
.
R
a
nc
a
n
g
a
n
p
e
ne
li
ti
a
n
ini
a
da
lah
e
x
planat
ory
r
e
se
arch
da
n
c
onfi
rmatory
re
se
ac
h.
Ha
sil
pe
ne
li
ti
a
n
menunjukka
n
ba
hwa
(1)
Kua
li
tas
L
a
y
a
na
n
be
rp
e
n
g
a
ruh
sig
nifika
n
t
e
rha
d
a
p
ke
pua
sa
n
konsum
e
n
,
(2)
Re
tai
l
M
arke
ti
ng
Mi
x
be
rpe
nga
ruh
sig
ni
fika
n
ter
h
a
da
p
ke
pua
sa
n
konsum
e
n
,
(3)
Kua
li
tas
la
y
a
na
n
ti
da
k
be
rp
e
n
g
a
ruh
sig
nifik
a
n
ter
h
a
da
p
lo
y
a
li
tas
konsum
e
n
,
(4)
R
e
tail
mar
ke
ti
ng
ti
da
k
be
rpe
n
ga
ruh
sig
nifika
n
t
e
rha
d
a
p
lo
y
a
li
tas
konsum
e
n
,
(5
)
Ke
pua
sa
n
konsum
e
n
be
rpe
n
ga
ruh s
ig
nifika
n
te
rha
da
p lo
y
a
li
t
a
s konsum
e
n
thermal-vapours/TAS-Transmission-Atom-Surface: TAS-Transmission-Atom-Surface release ver 0.0.3
No full text<p>TAS - Transmission spectra with Atom-Surface interactions see <a href="https://github.com/thermal-vapours/TAS-Transmission-Atom-Surface">GitHub repository main page</a> for more information.</p>
On-the-job learning and earnings
No full textA simple model of informal learning on-the-job which combines learning by oneself and learning from others is proposed in this paper. It yields a closed-form solution that revises Mincer-Jovanovic's (1981) treatment of tenure in the human capital earnings function by relating earnings to the individual's learning potential from jobs and firms. We estimate the structural parameters of this non-linear model on a large French survey with matched employer-employee data. We find that workers on average can learn from others ten percent of their own human capital on entering the firm, and catch half of their learning potential in just two years. The measurement of worker's learning potential in their jobs and establishments provides a simple characterization of primary-type and secondary-type jobs and establishments. We find a strong relationship between the job-specific learning potential and tenure. Predictions of dual labor market theory regarding the positive match of primary-type firms (which offer high learning opportunities) with highly endowed workers (educated, high wages) are visible at the establishment level but seem to vanish at the job's level.Human capital, earnings functions, informal training, learning from others, learning by oneself, returns to tenure, dualism.
Factors associated with the performance and cost-effectiveness of using lymphatic filariasis transmission assessment surveys for monitoring soil-transmitted helminths: a case study in Kenya.
No full textTransmission assessment surveys (TAS) for lymphatic filariasis have been proposed as a platform to assess the impact of mass drug administration (MDA) on soil-transmitted helminths (STHs). This study used computer simulation and field data from pre- and post-MDA settings across Kenya to evaluate the performance and cost-effectiveness of the TAS design for STH assessment compared with alternative survey designs. Variations in the TAS design and different sample sizes and diagnostic methods were also evaluated. The district-level TAS design correctly classified more districts compared with standard STH designs in pre-MDA settings. Aggregating districts into larger evaluation units in a TAS design decreased performance, whereas age group sampled and sample size had minimal impact. The low diagnostic sensitivity of Kato-Katz and mini-FLOTAC methods was found to increase misclassification. We recommend using a district-level TAS among children 8-10 years of age to assess STH but suggest that key consideration is given to evaluation unit size
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner
No full textCb2, the gene encoding the peripheral cannabinoid receptor, is located in a common virus integration site and is overexpressed in retrovirally induced murine myeloid leukemias. Here we show that this G protein-coupled receptor (GPCR) is also aberrantly expressed in a high percentage of human acute myeloid leukemias. We investigated the mechanism of transformation by Cb2 and demonstrate that aberrant expression of this receptor on hematopoietic precursor cells results in distinct effects depending on the ligand used. Cb2-expressing myeloid precursors migrate upon stimulation by the endocannabinoid 2-arachidonoylglycerol and are blocked in neutrophilic differentiation upon exposure to another ligand, CP55940. Both effects depend on the activation of G(alphai) proteins and require the mitogen-induced extracellular kinase/extracellular signal-regulated kinase (MEK/ ERK) pathway. Down-regulation of cyclic adenosine monophosphate (cAMP) levels upon G(alphai) activation is important for migration induction but is irrelevant for the maturation arrest. Moreover, the highly conserved G protein-interacting DRY motif, present in the second intracellular loop of GPCRs, is critical for migration but unimportant for the differentiation block. This suggests that the Cb2-mediated differentiation block requires interaction of G(alphai) proteins with other currently unknown motifs. This indicates a unique mechanism by which a transforming GPCR, in a ligand-dependent manner, causes 2 distinct oncogenic effects: altered migration and block of neutrophilic development. (C) 2004 by The American Society of Hematology
Screening and evaluation of antioxidant activity of some amido-carbonyl oxime derivatives and their radical scavenging activities
No full textTAS, MURAT/0000-0002-2879-6501; OZEN, Tevfik/0000-0003-0133-5630WOS: 000271613300015PubMed: 19772487The antioxidant activity of some amido-carbonyl oximes containing a C=O and -NH-R adjacent to the oxime group, [Phenyl-C(=O)-C(=N-OH)-N(-H)-Phenyl(-R)] where R=H, 4-chloro, 4-methyl, 4-methoxy, 3,4-dichloro, 3,4-dimethyl, 3-chloro-4-dimethyl, 3-chloro-4-methoxy, naphthyl and an amido-carbonyl dioxime were investigated in vitro by ferric thiocyanate, total reducing power by potassium ferricyanide reduction, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, ferrous ions chelating, superoxide anion radical scavenging and hydrogen peroxide scavenging activity assays. The results indicated that the amido-carbonyl oximes have powerful antioxidant capacity
IDENT IF IKAS I FAK T OR P E NY E B AB DA N UPA YA P E NA N GG UL AN G A N K E M IS K I N AN K ABU P ATE N JEMBE R
No full textB
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rk
a
n
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ta
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23,58
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f.
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da
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usia
di
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tahun
se
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43.6
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76,20
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13.627
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2
Aspe
k
ke
lemba
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n
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a
spek
utama
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ke
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di
Ka
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Ha
l
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da
pa
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dil
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na
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nda
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g
a
bun
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a
n
pa
r
a
re
sponde
n
menunjukka
n
ba
hwa
fa
ktor
ke
le
mbaga
a
n
(nila
i
bobot
0,283)
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upa
ka
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fa
kto
r
pa
li
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g
pe
nti
ng
y
a
n
g
pe
rlu
diper
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ti
ka
n
da
l
a
m
men
e
ntukan
pe
n
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e
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skinan
di
Ka
bupa
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a
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a
n
g
dikemuka
ka
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p
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ne
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ti
a
n
ini
m
e
nc
a
kup
ti
g
a
kr
it
e
ria
,
y
a
it
u
:
a
kses
lemba
ga
ke
ua
n
g
a
n;
a
kse
s
infor
masi;
da
n
a
kses
pa
sa
r.
Da
ri
ke
ti
g
a
kr
it
e
ria
ter
se
but,
kr
it
e
ria
y
a
n
g
dipanda
ng
utam
a
oleh
pa
ra
r
e
sponde
n
da
lam
mene
ntukan
pe
n
y
e
ba
b
k
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mi
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a
da
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a
kses
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n
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a
n
(nila
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bobot
0,175)
.
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it
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lanjutn
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memil
iki
nil
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i
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ingg
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a
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da
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: akse
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masi
(nila
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0,087)
;
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(
nil
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i
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0,021)
.
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dua
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g
a
a
n.
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mpl
ikasi
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ma
a
da
lah
k
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mi
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lebih
diseba
bka
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da
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da
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si
kedua
a
da
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ga
a
n
y
a
n
g
a
da
s
e
la
ma
ini
ti
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ipt
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n
y
a
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a
n
g
mem
ung
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mas
y
a
ra
k
a
t
mi
ski
n
mampu
menga
kses
f
a
sil
it
a
s
fa
sil
it
a
s
baik e
konomi
maupun non e
konomi
.
3
Aspe
k
ke
dua
y
a
n
g
menj
a
di
pe
n
y
e
ba
b
ke
mi
skina
n
di
Ka
bupa
ten
J
e
mber
a
da
lah
a
spek
e
konomi
.
B
e
rd
a
s
a
rka
n
ha
sil
a
na
li
sis
menunjukka
n
ba
hwa
kr
it
e
r
ia
y
a
n
g
memil
iki
pr
ioritas
ter
ti
ngg
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a
d
a
lah
a
lt
e
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ti
f
mata
pe
nc
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ri
a
n
(nila
i
bobot
0,114)
,
ke
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a
n
be
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ur
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0,045)
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n
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0,024)
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a
a
tan
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i
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0,023)
,
da
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unsur moda
l
da
n
pe
ra
l
a
tan
(
nil
a
i
bobo
t
0,021).
4
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k
ke
ti
g
a
y
a
n
g
m
e
n
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n
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e
b
a
b
ke
mi
skin
a
n
a
d
a
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a
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a
l
da
n
fisik.
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k
ter
se
but
ter
ka
it
lang
sun
g
de
n
ga
n
kua
li
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sumb
e
rda
y
a
manu
sia
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ra
k
a
t
mi
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it
u
se
ndiri.
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p
e
nti
ng
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ma
da
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a
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l
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fisik
a
da
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pe
ndidi
ka
n
(
bobot
nil
a
i
0,117)
,
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u
l
unsur
usia
(bobo
t
nil
a
i
0,054)
,
ke
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a
n
masing
masing
unsur
k
e
se
ha
t
a
n
(bobo
t
nil
a
i
0,027)
,
da
n
unsur
jum
lah
ke
luar
g
a
(bobo
t
ni
lai
0,024)
.
5
Aspe
k
ke
e
mpat
pe
n
y
e
b
a
b
ke
mi
skinan
di
Ka
bupa
ten
J
e
mber
a
da
lah
a
spek
g
e
o
gr
a
fis
d
a
n
li
ng
kun
ga
n.
Ha
l
ter
s
e
but
be
rk
a
it
a
n
de
n
g
a
n
ku
a
li
tas
sumb
e
rda
y
a
a
lam
da
n
kua
li
tas
in
fr
a
struktur.
Unsur
pe
nti
ng
pe
rta
ma
da
ri
a
spek
g
e
o
g
r
a
f
is
da
n
li
ng
kun
g
a
n
a
d
a
lah
kua
l
it
a
s
infr
a
struktur
(bobo
t
nil
a
i
0,084)
,
disus
ul
unsur
kua
li
tas
laha
n
(bobo
t
ni
lai
0,062)
,
da
n
unsur
k
ua
li
tas
li
ng
kun
g
a
n
(bob
ot
nil
a
i
0,015)
.
6
Aspe
k
ter
a
khir,
y
a
it
u
a
spek
ke
li
m
a
a
da
lah
a
spek
sosi
a
l
buda
y
a
,
y
a
n
g
be
r
ka
it
a
n
lang
sun
g
de
n
ga
n
ke
ma
mpuan
hubunga
n
a
ntar
manusia.
Unsur
pe
nti
n
g
pe
rta
m
a
da
ri
a
spek
sosi
a
l
buda
y
a
a
da
lah
ke
mampua
n
menc
ipt
a
ka
n
lapa
nga
n
usaha
d
e
nga
n
bobot
nil
a
i
(0,05
4)
,
disus
ul
unsur
ke
mampua
n
meng
e
lol
a
a
s
e
t
(bo
bot
nil
a
i
0,024)
, ke
mudi
a
n
be
rtur
ut
tu
rut
ke
rja
sa
m
a
da
n
o
r
g
a
ni
sa
si
(bobo
t
nil
a
i
0,016
),
da
n
pa
rtisi
pa
si
s
osial
(bobot nil
a
i
0,014)
OP TI M A SI P EN G A TU R A N TAP O N L O AD T AP CHA N G ER P A D A TRAN SF O R M A TOR 150/2 0 KV D I GA R D U IND U K J EM BER M EN GG U N A KA N M ETOD E FU Z Z Y L O G I C CO N T RO L L ER
No full textEne
r
g
i
li
st
rik
menja
di
sa
lah
sa
tu
ke
butuhan
utama
mas
y
a
ra
k
a
t
ka
re
na
mer
upa
ka
n
c
a
tu
d
a
y
a
p
e
ne
ra
n
g
a
n
da
n
p
e
r
a
lata
n
e
lektro
nik.
Ada
be
be
ra
p
a
pa
r
a
mete
r
y
a
n
g
d
a
pa
t
mempe
n
g
a
r
uhi
kua
li
tas
e
ne
rg
i
li
strik
sa
lah
sa
tun
y
a
a
d
a
lah
fluktua
si
tega
n
g
a
n.
Ke
ti
da
kstabil
a
n
te
g
a
n
g
a
n
a
k
a
n
men
y
e
b
a
bka
n
k
e
ti
da
kstabil
a
n
sis
tem
tena
g
a
se
c
a
r
a
k
e
se
luruha
n
ter
utama
ke
mampua
n
tra
nsfe
r
d
a
y
a
d
a
ri
p
e
mbang
kit
k
e
konsum
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n.
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a
ktor
y
a
n
g
da
p
a
t
mem
pe
nga
ruhi
k
e
ti
da
kstabil
a
n
tega
n
g
a
n
a
da
l
a
h
dina
mi
ka
O
L
TC
(O
n
L
oad
T
ap
C
hange
r)
pa
d
a
tra
nsf
or
mator
.
P
e
nge
nda
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a
n
ke
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tega
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men
gg
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a
ka
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b
e
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ga
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pe
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a
a
n
d
a
y
a
d
a
n
tega
n
g
a
n
menja
di
lebih
e
konomi
s
da
n
e
fisien,
ka
re
na
te
ga
n
g
a
n
y
a
n
g
dig
un
a
ka
n
d
a
la
m
ke
a
da
a
n
se
suai
(sta
bil
)
de
n
g
a
n
te
g
a
n
ga
n
y
a
n
g
didesa
in
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a
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pe
ra
lat
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n
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n
g
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i
sa
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pa
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ba
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ter
ten
tu.
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L
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a
da
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se
bu
a
h
komponen
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k
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n
pa
d
a
tr
a
nsfo
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tor
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di
g
a
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tra
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L
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be
rf
un
g
si
se
ba
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i
pe
n
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ub
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h
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da
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da
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e
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b
a
n
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a
ng
d
a
pa
t
mela
kuka
n
p
e
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uba
ha
n
tap
untuk
mena
mbah
a
tau
m
e
ng
u
ra
n
g
i
jum
lah
k
u
mpa
ra
n
p
a
da
tr
a
nsfor
m
a
tor
t
a
npa
h
a
rus
mela
kuka
n
pe
m
a
da
man
ter
lebih
da
hulu.
T
a
p
O
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ini
da
pa
t
diubah
se
s
ua
i
v
olt
age
e
rror
pa
da
tr
a
nsfor
mato
r
di
sis
i
pr
im
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r.
Metode
y
a
n
g
a
ka
n
di
g
un
a
ka
n
a
d
a
lah
fuzz
y
logi
c
c
ontro
ll
e
r
dim
a
na
t
e
rda
pa
t
dua
masuka
n
y
a
i
tu,
v
olt
ag
e
e
rror
(se
li
sih
teg
a
n
ga
n)
da
n
c
urrent
tap
posi
ti
on
(posisi
tap
se
ka
ra
ng
)
s
e
da
n
g
ka
n
sa
tu
ke
luar
a
n
n
y
a
be
rupa
direc
ti
on of t
ap c
hange
(
a
ra
h pe
ruba
h
a
n tap)
.
Tujua
n
da
ri
p
e
ne
li
ti
a
n
in
i
a
da
lah
untuk
m
e
n
g
a
na
l
isi
s
opti
masi
pe
ng
a
tur
a
n
posi
si
tap
O
L
TC
pa
d
a
tra
nsfor
mat
or
150/20
kV.
S
e
lain
it
u,
dihar
a
pka
n
mampu
mempe
rba
iki
ke
stabil
a
n
tega
n
g
a
n
se
k
unde
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y
a
n
g
a
ka
n
disalu
rka
n
ke
konsum
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n
mengg
una
k
a
n
metode
fuzz
y
logi
c
c
ontro
ll
e
r.
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ga
n
g
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p
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(V
p
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sudah
m
e
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a
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ikan
d
e
n
g
a
n
mengg
un
a
ka
n
m
e
tode
f
uzzy
logi
c
c
ontro
ll
e
r
d
idala
m
O
L
TC
pa
d
a
tr
a
nsfor
mator
150/20
kV
da
pa
t
men
g
h
a
sil
ka
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pe
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se
hingga
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g
a
n
g
a
n
se
kunde
r
(V
se
kund
e
r)
y
a
ng
dihasil
ka
n
ju
g
a
a
k
a
n
stabil
.
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a
da
p
e
mode
lan
sis
tem
pe
nga
tura
n
tap
pa
da
tr
a
nsfor
mator
150/20
kV
d
e
nga
n
O
L
TC
untuk
kon
disi
sumb
e
r
tega
n
g
a
n
teta
p
se
be
s
a
r
150
kV
da
n
da
y
a
be
b
a
n
fluktua
ti
f
dihasil
ka
n
Vse
kunde
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be
sa
r
20364,125
V
±
369
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a
da
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kunde
r
y
a
n
g
dihasil
ka
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da
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pe
modela
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tem
pe
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tur
a
n
tap
p
a
da
tra
nsfo
rma
tor
150/2
0
kV
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te
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rub
a
h
da
n
d
a
y
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b
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n
ko
nstan
a
da
lah
20606
V
±
8664
V.
S
e
da
ng
k
a
n
Vs
e
kunde
r
y
a
ng
dihasil
ka
n
d
a
ri
p
e
modela
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sis
tem
pe
n
ga
tura
n
tap
pa
d
a
tra
nsfor
mator
150/20
kV
di
G
I
J
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mber
a
da
lah
2
1766.583
V
±
3995
V.
Da
ri
ke
ti
g
a
pe
modela
n
sis
tem
ter
se
but
ter
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Vse
kunde
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a
n
g
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n
mela
lui
pe
modela
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sis
tem
pe
ng
a
t
ur
a
n
tap
pa
da
tra
nsfo
rma
tor
150/20
kV
meng
g
un
a
ka
n
O
L
TC
da
n
metode
fuzz
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logi
c
c
ontro
ll
e
r
lebih
s
tabil
de
n
g
a
n
r
e
g
ulasi
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g
a
n
mi
nim
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5%
da
n maksim
a
l 10% da
ri
Vse
kunde
r
re
f
e
re
nsi
y
a
it
u 20
kV
Alexithymia as related to sex, age, and educational level: Results of the Toronto Alexithymia Scale in 417 normal subjects
No full textThe Toronto Alexithymia Scale (TAS) was administered to 417 normal subjects. Total TAS scores and scores of the four TAS factors were correlated with sex, age, and educational level. Age ranged from 21 to 64 years. The sample was subdivided into three groups according to age. TAS scores, both total and on single subfactors, were significantly greater in the higher age groups with respect to lower age groups. Subjects with a lower educational level scored higher on factors 1, 2, and 4 and had higher TAS total scores with respect to subjects with a higher educational level. As for sex, no significant differences in total TAS scores were obtained, but women scored higher at factor 1. Factor analysis of the TAS, performed on both the whole sample and the subgroups according to sex and age, confirmed the fair internal stability of the TAS
Tas-102 in metastatic colorectal cancer (MCRC): Efficacy, tolerability, and quality of life in heavily pretreated elderly patients: A real-life study
No full textBackground: TAS-102 is an oral monotherapy, combining trifluridine and tipiracil hydrochloride, indicated for the treatment of pretreated metastatic colorectal cancer (mCRC). The aim of this real-life study is to evaluate the efficacy and safety of TAS-102 in heavily pretreated elderly patients with mCRC whose disease has progressed with standard therapies. Methods: In this retrospective observational study, we enrolled 50 elderly patients >70 years of age (median age 78 years) with a diagnosis of mCRC who were previously treated or were not considered candidates for treatment with other available therapies. Patients aged >70 years with advanced colorectal cancer and with an ECOG performance status of grade 0 (n=18) or grade 1 (n=32) were included. Overall survival and progression-free survival were the primary endpoints, whereas objective response rate, tolerability, and quality of life were the secondary endpoints. Results: Treatment with TAS-102 appeared to be well tolerated and side effects were generally mild, achieving disease control and a benefit on quality of life. The median overall survival was 6.7 (95% CI 5.7-11.3) and the median progression-free survival was 2.1 months (95% CI 1.2-3.2), estimated using the Kaplan-Meier method. Conclusion: TAS-102 represents a manageable and effective therapeutic opportunity and appeared to be well tolerated with generally mild side effects in elderly patients with mCRC who were heavily pretreated with standard therapies
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