11 research outputs found
The effects of staff proximity on disruptive and on-task behaviors in autistic adolescents
No full textAutism is a lifelong condition, yet many supports for autistic individuals end abruptly upon graduation. As such, it is crucial for educators and practitioners to teach students with ASD to perform skills with minimal assistance and supervision. Staff proximity may impact on-task and disruptive behaviors amongst learners with ASD in school settings. Various interventions may be able to increase on-task behavior when staff are out of the learner’s sight. The current investigation consisted of two parts. Part one evaluated the impact of staff standing at various distances on the disruptive and on-task behaviors of three adolescent males with ASD. Part two examined the efficacy of a visual cue, and the visual cue plus differential reinforcement on increasing the participants’ on-task behaviors when staff were out of sight. For two participants, on-task behavior was lower when staff were out of sight. These findings suggest staff being out of sight may negatively impact on-task behavior, but this effect does not apply to all individuals. The visual cue plus differential reinforcement was effective for one participant, suggesting effective interventions may vary.M.A.B.A.Includes bibliographical reference
Prozzo N., Sarno E., Volpe A., Beni ambientali e culturali. Una lettura interdisciplinare
No full textInclusive research and inclusive education: why connecting them makes sense for teachers’ and learners’ democratic development of education
No full textFollowing pushes from the disability movement(s) and increased interest in children and young people becoming involved in research concerning them, inclusive research is growing within and beyond education establishments. Yet this arena is alive with interesting and largely unanswered questions. This paper discusses some of them: What do inclusive research and inclusive education have in common? Where have the moves towards inclusive (participatory and emancipatory) research happened and why? How viable are the claims to the moral superiority of inclusive research? What kinds and quality of knowledge does inclusive research produce? Finally the question is addressed of what all this means for inclusive education, arguing that inclusive research has under-explored potential to reinvigorate inclusive education and provide new connections to democracy and social justice in education
Diritto e nuove tecnologie. Tra comparazione e interdisciplinarità.
No full textIl fascicolo raccoglie gli atti del Seminario di diritto comparato dell’Associazione “Gruppo di Pisa” del 26 marzo 2021 su
“Diritto e nuove tecnologie tra comparazione e interdisciplinarità” – Università degli Studi di Milano
Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice
No full textIncludes abstract.Includes bibliographical references (leaves 139-148).The devastating effect the HIV pandemic has had on the human population in the last twenty five years has highlighted the great need to develop a prophylactic HIV vaccine. The manufacture of a vaccine has proven difficult though, with a number of successful designs in animal models having little success in humans. In view of this, there has been a need for novel vaccine approaches that are able to elicit effective cellular and humoral immune responses, both of which are believed to be important in the eradication of the virus. One such approach is the use of HIV-1 Gag VLPs as vaccine candidates. In this study, the production of two chimaeric (Gag VLP vaccine candidates (GagRT and GagTN) was optimized in insect cells, and their ability to enhance a murine immune response in a DNA prime-VLP boost vaccine strategy was evaluated
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
No full textBackgroundTocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.MethodsA multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, a priori expected rates being 20 and 35%, respectively). A further prospective cohort of patients, consecutively enrolled after the first cohort was accomplished, was used as a secondary validation dataset. The two cohorts were evaluated jointly in an exploratory multivariable logistic regression model to assess prognostic variables on survival.ResultsIn the primary intention-to-treat (ITT) phase 2 population, 180/301 (59.8%) subjects received tocilizumab, and 67 deaths were observed overall. Lethality rates were equal to 18.4% (97.5% CI: 13.6-24.0, P=0.52) and 22.4% (97.5% CI: 17.2-28.3, P<0.001) at 14 and 30 days, respectively. Lethality rates were lower in the validation dataset, that included 920 patients. No signal of specific drug toxicity was reported. In the exploratory multivariable logistic regression analysis, older age and lower PaO2/FiO2 ratio negatively affected survival, while the concurrent use of steroids was associated with greater survival. A statistically significant interaction was found between tocilizumab and respiratory support, suggesting that tocilizumab might be more effective in patients not requiring mechanical respiratory support at baseline.ConclusionsTocilizumab reduced lethality rate at 30 days compared with null hypothesis, without significant toxicity. Possibly, this effect could be limited to patients not requiring mechanical respiratory support at baseline.Registration EudraCT (2020-001110-38); clinicaltrials.gov (NCT04317092)
