1,721,036 research outputs found
Characterization of thick γ-FeOOH layers by an in situ electrochemical technique
No full textThe features of γ-FeOOH layers deposited by the anodic oxidation of ferrous ions are investigated by a non-steady-state diffusion technique. The oxide is found to present the behaviour of a homogeneous layer up to a thickness of ≈600 Å; thereafter modifications possibly involving structural rearrangements of the layer are detected. The activation energy of the diffusion process is determined. Results are considered to be relevant to the understanding of the complex behaviour of protective oxide layers on iron alloys. © 1983
Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study
Full text linkDisturbances of skin barrier function occur in several skin diseases, e.g., atopic dermatitis (AD), irritant/allergic contact dermatitis (ICD, ACD). Skin barrier damage triggers the production of cytokines that stimulate lipogenesis which may also cause inflammatory processes. The aim of this study was to evaluate the efficacy of a topical skin lipid mixture in the treatment of ICD, ACD and AD. 580 consecutive patients suffering from ICD, ACD or AD were treated with a skin lipid mixture containing ceramide-3 and patented nanoparticles. Patients received the lipid mixture alone or in combination with topical corticosteroids until clearance or for 8 weeks. Both treatment groups statistically improved all parameters considered at week 4 and 8 as compared to baseline. Between the 2 treatment groups, there was a statistically significant difference in favour of combined therapy for (ICD, ACD, AD, respectively): erythema, pruritus and overall disease severity; erythema and pruritus; erythema, pruritus, fissuring and overall disease severity. No statistically significant difference was found for (ICD, ACD, AD, respectively): dryness, scaling and fissuring; scaling, fissuring and overall disease severity; dryness and scaling. Between the 2 ACD treatment groups, there was a statistically significant difference in favour of the skin lipid mixture for dryness. In conclusion, the study shows that balanced lipid mixtures are effective in improving barrier properties and the clinical condition of the skin in contact dermatitis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
CD40 ligand expression in mycosis fungoides is restricted to the patch/plaque (epidermotropic) stages
No full textCD40 ligand (CD40L) is a member of the tumor necrosis factor ligand superfamily. It may play an intricate role in the immune response by functional interaction with CD40 antigen expressed on the surface of B- cells, T-cells, monocytes, macrophages, antigen-presenting cells, endothelial cells and some epithelial cells. A possible role of CD40L in the pathogenesis of non-Hodgkin's lymphoma (NHL) has been recently hypothesized; in fact, CD40L antigen can be constitutively expressed by the neoplastic CD4sup + T-cell of nodal NHL, thus possibly having a physiological role in these neoplasms. We studied the immunophenotypic and genotypic expression of CD40L antigen in different phases of mycosis fungoides - the prototype of cutaneous T-cell lymphoma - in order to investigate the possible significance and role of this molecule in its pathomechanism. On frozen sections, CD40Lsup + T-cells were present in 9/10 specimens from patch/plaque stage mycosis fungoides. Their percentage (10-25%) and location (junctional and basal epidermal) were very similar to those of CD25sup + and Ki67sup + (proliferating) cells. In 5/5 specimens from tumor stage mycosis fungoides, no CD40L immunostaining was found. All patch/plaque stage mycosis fungoides (6/6 specimens) contained the mRNA transcript for CD40L. It was never detected in tumor stage mycosis fungoides (4/4 specimens). These findings suggest that in early mycosis fungoides, CD40Lsup + T-cells home into the skin by interaction with CD40sup + endothelial cells and into the epidermis by interaction with CD40sup + basal epidermal cells. The interaction between CD40Lsup + T-cells and CD40sup + Langerhans cells and the CD40/CD40L autocrine stimulus possibly triggers activation, growth and neoplastic enhancement of T-cells; up to the blastic transformation occurring at the tumor stage, when neoplastic T-cells loose their antigenic and functional features of mature T-cells and proliferate without any significant control
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Detection of clonality in cutaneous B-cell lymphomas by polymerase chain reaction gene amplification.
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