1,596 research outputs found
Untying the Gordian knot of cytokinesis: role of small G proteins and their regulators
No full text© The Rockefeller University PressSergei N. Prokopenko, Robert Saint, and Hugo J. Belle
Oktyabrskaya revolyutsiya v zerkale italyanskoy provintsialnoy pechati v 1917-1918 gg.: na primere gazety "Bergamskoe èkho"
No full textDopo aver delineato una breve storia del giornale bergamasco "L'Eco di Bergamo", l'articolo si addentra nell'analisi delle notizie sulla Rivoluzione russa, sulla loro frequenza, tonalità, esaustività. Dall'analisi risulta un'attenzione alla politica di quel lontano paese inaspettata in un giornale della provincia italiana.After outlining a brief history of the Bergamo newspaper "L'Eco di Bergamo", the article goes into the analysis of the news on the Russian Revolution, on their frequency, tone and completeness. The analysis shows an unexpected attention to the politics of that distant country in a newspaper of the Italian province
Milan Kubr et Joseph Prokopenko : Les besoins de formation au management. Principes et méthodes de diagnostic
No full textBurlaud Alain. Milan Kubr et Joseph Prokopenko : Les besoins de formation au management. Principes et méthodes de diagnostic . In: Politiques et management public, vol. 9, n° 4, 1991. pp. 143-145
The output stage of an operational amplifier on GaAs n-channel field-effect and GaAs p-n-p bipolar transistors with nonlinear negative feedback
No full textA new circuit of the output stage of an operational amplifier
implemented on GaAs n-channel field-effect transistors with a control p-n
junction and GaAs bipolar p-n-p transistors is investigated. Its peculiarity
consists in the presence of a nonlinear negative feedback that stabilizes the
drain current of the output transistor with an n-channel at a negative input
voltage. The basic equations for the static mode of the output stage are given.
The results of modeling in the LTspice simulation software of 3 modifications
of the proposed circuit solutions are discussed.</p
“Peculiarity is What Attracts Here a Historian”
No full textPublication of the conversation of S.N. Prokopenko with Professor A.A. Maslennikov - Russian archaeologist, antiquarian, specialist in the history of the ancient Bosporu
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
No full textTo identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy
Two-Layered WGM Resonator-Based Technique for Microwave Characterization of Condensed Matter with Extremely High and Extremely Low Losses
No full textNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
No full textCirculating glucose levels are tightly regulated. To identify novel glycemic loci, we performed
meta-analyses of 21 genome-wide associations studies informative for fasting glucose (FG),
fasting insulin (FI) and indices of β-cell function (HOMA-B) and insulin resistance (HOMA-IR)
in up to 46,186 non-diabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects
identified 16 loci associated with FG/HOMA-B and two associated with FI/HOMA-IR. These
include nine new FG loci (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2,
PROX1 and FAM148B) and one influencing FI/HOMA-IR (near IGF1). We also demonstrated
association of ADCY5, PROX1, GCK, GCKR and DGKB/TMEM195 with type 2 diabetes (T2D).
Within these loci, likely biological candidate genes influence signal transduction, cell
proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that
genetic studies of glycemic traits can identify T2D risk loci, as well as loci that elevate FG
modestly, but do not cause overt diabetes
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