311 research outputs found
Oleh Semenovych Pidhainy. The Ukrainian Republic in the Great East-European Revolution. I : The Formation of the Ukrainian Republic. Préface par M. Mladenovic, 1966
No full textNahon Gérard. Oleh Semenovych Pidhainy. The Ukrainian Republic in the Great East-European Revolution. I : The Formation of the Ukrainian Republic. Préface par M. Mladenovic, 1966. In: Revue des études juives, tome 128, n°2-3, avril-septembre 1969. pp. 304-305
Generating Good Starting Solutions for the p-median Problem in the Plane
No full textIn this paper we examine a new procedure for generating starting solutions for the continuous p-median problem in the plane. Preliminary results indicate that local optima of much better quality are obtained using this method. The next step in our study will be to determine if these starting solutions enhance the performance of existing heuristics that are based on variable neighborhood search
A New Local Search for Continuous Location Problems
No full textThis paper presents a new local search approach for solving continuous location problems. The main idea is to exploit the relation between the continuous model and its discrete counterpart. A local search is first conducted in the continuous space until a local optimum is reached. It then switches to a discrete space that represents a discretisation of the continuous model to find an improved solution from there. The process continues switching between the two problem formulations until no further improvement can be found in either. Thus, we may view the procedure as a new adaption of formulation space search. The local search is applied to the multi-source Weber problem where encouraging results are obtained. This local search is also embedded within Variable Neighbourhood Search producing excellent results
HIV-Infected Children and Nutrition: The Friend and The Foe
No full textThe impact of nutrition on HIV-infected children has been evaluated in
multiple studies. Our review of the current trends of nutrition-related studies
revealed that the focus has moved from simply the disease consequences of HIV to
ensuring that antiretroviral therapy-treated children are well nourished to ensure
growth and development. This update aims to present the state of the art regarding
nutrition of HIV-infected children and the real potential for nutrition to serve
as a dynamic therapy in this group. Recent World Health Organization reports
indicate that the HIV/AIDS disease is curbing in incidence worldwide despite the
high 1.8 million children, less than 15 years, reported in 2017. In addition, the
literature supports the complexity and bidirectional relation between nutrition
and HIV. HIV infection has a substantial effect on the nutritional status, in particular,
the gastrointestinal side effects, which, in turn, have a profound impact on
HIV infection. Advances in the field have transformed the course of the disease
into a chronic illness, where more attention was given to lifestyle and quality of life
including nutrition. However, achievement of food security, nutrition accessibility,
and appropriate handling of nutrition-related complications of HIV infection are
remarkable challenge
Heuristic Procedures for Solving the Discrete Ordered Median Problem
No full textWe present two heuristic methods for solving the Discrete Ordered Median Problem (DOMP), for which no such approaches have been developed so far. The DOMP generalizes classical discrete facility location problems, such as the p-median, p-center and Uncapacitated Facility Location problems. The first procedure proposed in this paper is based on a genetic algorithm developed by Moreno Vega [MV96] for p-median and p-center problems. Additionally, a second heuristic approach based on the Variable Neighborhood Search metaheuristic (VNS) proposed by Hansen & Mladenovic [HM97] for the p-median problem is described. An extensive numerical study is presented to show the efficiency of both heuristics and compare them
Heuristic procedures for solving the discrete ordered median problem
No full textS.145-173We present two heuristic methods for solving the Discrete Ordered Median Problem (DOMP), for which no such approaches have been developed so far. The DOMP generalizes classical discrete facility location problems, such as the p-median and p-center. The first procedure proposed in this paper is based on a genetic algorithm developed by Moreno Vega (1996) for p-median and p-center problems. Additionally, a second heuristic approach based on the Variable Neighborhood Search metaheuristic (VNS) proposed by Hansen and Mladenovic (1997) for the p-median problem is described. An extensive numerical study is presented to show the efficiency of both heuristics and compare them.136Nr.
Rovibrational Hamiltonians for general polyatomic molecules in spherical polar parametrization. I. Orthogonal representations
No full textPosterInternational audienceThe interdependence of the description of the internal geometry and the corresponding kinetic energy operatorTˆ is investigated in detail for a general n-atomic molecule. For both space-fixed and body-fixed reference frames compact expressions of Tˆ are derived which are applicable to any set of n21 translationally and rotationally invariant internal vectors in a spherical polar parametrization. Simple analytical forms are given for reduced masses and kinetic coupling constants, which are the only vector specific parameters in the final rovibrational kinetic energy expression. The kinetic energy assumes the most separable form for an entirely orthogonal set of internal vectors. A highly efficient computer program for the calculation of rovibrational spectra of tetratomic molecules has been developed on the basis of this formulation. Calculations on the HF dimer and the metastable molecule HOCO illustrate the accuracy and flexibility of this approach
Human estrogen receptor α antagonists, part 2: Synthesis driven by rational design, in vitro antiproliferative, and in vivo anticancer evaluation of innovative coumarin-related antiestrogens as breast cancer suppressants
No full textNew twelve in silico designed coumarin-based ERα antagonists, namely 3DQ-1a to 3DQ-1е, were synthesized and confirmed as selective ERα antagonists, showing potencies ranging from single-digit nanomolar to picomolar. The hits were confirmed as selective estrogen receptor modulators and validated as antiproliferative agents using MCF-7 breast cancer cell lines exerting from picomolar to low nanomolar potency, at the same time showing no agonistic activity within endometrial cell lines. Their mechanism of action was inspected and revealed to be through the inhibition of the Raf-1/MAPK/ERK signal transduction pathway, preventing hormone-mediated gene expression on either genomic direct or genomic indirect level, and stopping the MCF-7 cells proliferation at G0/G1 phase. In vivo experiments, by means of the per os administration to female Wistar rats with pre-induced breast cancer, distinguished six derivatives, 3DQ-4a, 3DQ-2a, 3DQ-1a, 3DQ-1b, 3DQ-2b, and 3DQ-3b, showing remarkable potency as tumor suppressors endowed with optimal pharmacokinetic profiles and no significant histopathological profiles. The presented data indicate the new compounds as potential candidates to be submitted in clinical trials for breast cancer therapy
Theoretical investigations of proton-bound cluster ions
No full textSeveral proton-bound cluster ions have been studied by means of coupled cluster calculations with large basis sets. Among these are complexes of a krypton or xenon atom with the cations HCO+, HN2+ and HNCH+. Various spectroscopic properties have been calculated in all cases. Effects of vibrational anharmonicity are particularly pronounced for the intramolecular stretching vibrations of and Kr . . . HN2+ and Xe . . . HN2+. The proton stretching vibration of (N-2)H+(N-2) is predicted around 800 cm(-1), with a large transition dipole moment of 1.15 D. Both(N-2)H+(N-2) and (HCN)H+ (NCH) have linear centrosymmetric equilibrium structures. Those of (OC)H+ (CO) and (HCC-)H+(CCH-) are asymmetric with barrier heights to the centrosymmetric saddle points of 382 and 2323 cm(-1), respectively. The dissociation energy of the anionic complex Cl-. . . HCCH is calculated to be D-o = 3665 cm(-1), 650 cm(-1) larger than the corresponding value for Br-. . . HCCH. The complex between a fluoride ion and acetylene is more strongly bound and shows strongly anharmonic behaviour, similar to the bihalides FHF- or ClHCl-. Strong Fermi resonance interaction is predicted between v(3) (similar to proton stretch) and 2v(4) (Drst overtone of intermolecular stretch)
Species composition and stand structure in the urban forest: Comparing remnant forest patches and secondary growth in Toronto's ravine system
No full textForested patches within urban areas provide essential ecosystem services and play a critical role in preserving urban biodiversity. Based on their origin, forested patches can be classified as remnant forests, areas that have not been cleared and have remained forested throughout urbanization, or secondary forests, established on land previously cleared for alternative uses. This capstone project compares species composition and stand structure between remnant forest patches and secondary growth within the G. Ross Lord Park, part of Toronto’s extensive ravine network. Using the Vegetation Sampling Protocol (VSP), 54 fixed-area plots were surveyed to assess native and nonnative plant abundance, species richness, and floristic quality across canopy and understory strata. Historical forest cover mapping from 1954 was integrated with field data to classify monitoring plots according to their proximity to remnant forest patches. This allowed for the examination of ecological patterns using Kruskal–Wallis tests, Spearman’s correlation tests, and Generalized Linear Models. The results demonstrated that remnant forest patches exhibited higher native species richness and stronger floristic quality, particularly within the tree layer. Remnant forest patches also contained fewer nonnative tree species compared to secondary forests. These findings indicate that remnant forests serve as important refuges for native vegetation within urban forests and highlight the long-lasting effects of historical land use on secondary forests. This project provides evidence-based management recommendations to guide conservation and restoration efforts in the G. Ross Lord Park. It emphasizes the need to protect remnant forest patches, prioritize invasive species removal at remnant edges, and support assisted regeneration in secondary forests to strengthen ecological resilience across the ravine system
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