342 research outputs found
Capitolo 1.3 - La biodiversità: le specie vegetali
No full textSi tratta di una rassegna del patrimonio naturale vegetale (specie e comunità) di uno dei tratti di costa emiliano-romagnola di maggior pregio naturalistico, area protetta della Rete Ecologica Natura 2000
L'informazione e la comunicazione pubblica: dalla legge n. 150 alle prospettive di differenziazione regionale
No full textLa 'moralizzazione' delle università (commento a decr. legge 10 novembre 2008, n. 180 conv. con modif., dalla legge 9 gennaio 2009, n. 1)
No full textIl d. lgs. n. 39 del 2013. Inconferibilità e incompatibilità degli incarichi nella prospettiva dell’imparzialità dei funzionari pubblici.
No full textLa trasparenza come strumento di lotta alla corruzione tra legge n. 190 del 2012 e d. lgs. n. 33 del 2013.
No full textTailored therapy in patients treated with fluoropyrimidines: focus on the role of dihydropyrimidine dehydrogenase
No full textFluoropyrimidines are widely used in the treatment of solid tumors, mainly gastrointestinal, head and neck and breast cancer. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for catabolism of 5-FU and it is encoded by DPYD gene. To date, many known polymorphisms cause DPD deficiency and subsequent increase of 5-FU toxicity. In addition, reduced inactivation of 5-FU could lead to increased 5-FU intracellular concentration and augmented efficacy of this drugs. Therefore DPD expression, particularly intratumoral, has been investigated as predictive and prognostic marker in 5-FU treated patients. There also seems to be a tendency to support the correlation between DPD expression and response/survival in patients treated with fluoropyrimidine even if definitive conclusions cannot be drawn considering that some studies are conflicting. Therefore, the debate on intratumoral DPD expression as a potential predictor and prognostic marker in patients treated with fluoropyrimidines is still open. Four DPD-polymorphisms are the most relevant for their frequency in population and clinical relevance. Many studies demonstrate that treating a carrier of one of these polymorphisms with a full dose of fluoropyrimidine can expose patient to a severe, even life-threatening, toxicity. Severe toxicity is reduced if this kind of patients received a dose-adjustment after being genotyped. CPIC (Clinical Pharmacogenetics Implementation Consortium) is an International Consortium creating guidelines for facilitating use of pharmacogenetic tests for patient care and helps clinicians ensuring a safer drug delivery to the patient. Using predictive DPD deficiency tests in patients receiving 5FU-based chemotherapy, in particular for colorectal cancer, has proven to be a cost-effective strategy
SATELLITE AND UNMANNED AERIAL VEHICLE DATA FOR THE CLASSIFICATION OF SAND DUNE VEGETATION
No full textWithin coastal systems, sand dunes are the only natural barriers able to counteract erosive processes. Since their equilibrium is often threatened by human activities and high vulnerability of the coastal environment, dunes require increasing attention and specific monitoring. Located between the mainland and the sea, dunes are unique residue habitats for some plant and animal species. In particular, their vegetation is important because it has a consolidation function and promotes the vertical dune accretion. A georeferenced vegetation classification can be useful to define the advancements or erosion stage of the dune, usually based only on the geometric reconstruction.
The proposed study aims to compare the classifications performed with some combinations of two of the last generation sensors and traditional image processing techniques. High spectral resolution satellite image (WorldView-2) and a multispectral orthophoto, obtained from data acquired by an unmanned aerial vehicle, were used. Objects and pixel algorithms were applied and the results were compared by a statistical test. Using the same bands, the findings show that both data are suitable for monitoring the evolutionary dune status. Specifically, the WorldView-2 pixel-based classification and UAV object-based classification provide the same accurate results
Comparison of pixel- and object-based classification methods of unmanned aerial vehicle data applied to coastal dune vegetation communities: Casal borsetti case study
No full textCoastal dunes provide the hinterland with natural protection from marine dynamics. The specialized plant species that constitute dune vegetation communities are descriptive of the dune evolution status, which in turn reveals the ongoing coastal dynamics. The aims of this paper were to demonstrate the applicability of a low-cost unmanned aerial system for the classification of dune vegetation, in order to determine the level of detail achievable for the identification of vegetation communities and define the best-performing classification method for the dune environment according to pixel-based and object-based approaches. These goals were pursued by studying the north-Adriatic coastal dunes of Casal Borsetti (Ravenna, Italy). Four classification algorithms were applied to three-band orthoimages (red, green, and near-infrared). All classification maps were validated through ground truthing, and comparisons were performed for the three statistical methods, based on the k coeffcient and on correctly and incorrectly classified pixel proportions of two maps. All classifications recognized the five vegetation classes considered, and high spatial resolution maps were produced (0.15 m). For both pixel-based and object-based methods, the support vector machine algorithm demonstrated a better accuracy for class recognition. The comparison revealed that an object approach is the better technique, although the required level of detail determines the final decision
Internationalisation in the household appliances sector in Fabriano (Italy). A case study
No full textThis paper analyses the household appliances district of Jesi-Fabriano. It shows how the internationalisation strategies of many enterprises are gradually modifying the organizational structure of the local production system. The diverse goals that have led the internationalisation processes and the strategies chosen by enterprises to effectively approach far away markets are at the core of the paper that includes a broad review of the fragmentation actions of the local enterprises. Special attention is paid to the effects of the internationalisation process on the relationships among actors along the whole filire and on the models of internal enterprise management. After an analysis of the history of the district and its current transformations, the main conclusions focus on possible scenarios regarding external and endogenous factors, on the main opportunities that enterprises should seize in order to successfully complete the ongoing internationalisation process and on the important role of local and national institutions in supporting the evolution of the model of local economic development.Internationalisation, Iinternational Fragmentation, Industrial Districts, Household Appliance Industry
FLUORINE SUBSTITUTION IN NEUROTRANSMITTERS: MICROWAVE SPECTROSCOPY AND MODELLING OF THE CONFORMATIONAL SPACE AND NON BONDING INTERACTIONS
No full textAuthor Institution: Dipartimento di Chimica Ciamician, Universita di Bologna, via Selmi 2,40126 Bologna, ItalyFluorine substitution in molecules is a common practice in bio-organic chemistry in order to modulate physicochemical properties and biological activity of molecules and an increasing number of drugs on the market contain fluorine, the presence of which is often of major importance to modify pharmacokinetics properties and molecular activity. The rationale for such a strategy is that fluorine is generally a stronger electron acceptor than the other halogen atoms and its size is intermediate between that of hydrogen and oxygen. We have studied two fluorinated analogs of 2-phenylethylamine (PEA), the prototype molecule for adrenergic neurotransmitters, namely: 4-Fluoro (4FPEA) and 2-Fluoro-2-phenylethylamine (2FPEA) by Molecular Beam Fourier Transform Microwave Spectroscopy in the frequency range 6-18 GHz and \textit{ab initio} calculations at the MP2/6311++G** level. The aim is to obtain information on the spatial arrangement of the ethylamine side chain and the effects of fluorination on the energy landscape. The conformational space is dominated by low energy \textit{gauche} conformations stabilized by weak interactions between the aminic hydrogens and the electron cloud of the benzene ring and \textit{anti} conformations higher in energy. In 2FPEA the presence of the fluorine atom almost duplicate the number of possible conformation with respect to 4FPEA. We observed two conformers of 4FPEA and five conformers of 2FPEA which have been classified with the guide provided by accurate \textit{ab initio} calculations. The identification of the conformational species was helped by the analysis of the quadrupole hyperfine pattern which is greatly influenced by the orientation of the amino group and acts as a fingerprint for each conformation. The orientation of the dipole moment within the principal axis frame and the order of stability of the different conformations are other independent pieces of evidence for the unambiguous assignment and identification of the conformers. The order of stability was found to be altered in both molecules with respect to the prototype PEA molecule, especially in the case of 2FPEA where we observe a stabilization of some of the \textit{anti} forms and great destabilization of some of the \textit{gauche} forms. These observations are in agreement with the results of the theoretical calculation and can be rationalized in terms of the effect of the fluorine atom on the electron density of the molecule and in particular on the electron cloud on the benzene ring
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