199 research outputs found
Fanton (A.), L'Abyssinie lors de l'expédition anglaise (1867-1868)
No full textJanin Raymond. Fanton (A.), L'Abyssinie lors de l'expédition anglaise (1867-1868). In: Échos d'Orient, tome 36, n°186, 1937. p. 242
Margaret Chase Smith Essay: The Right of Independent Thought
No full textThis essay by Jonathan F. Fanton investigates the relationship between the humanities and the right of independent thought, as described by Senator Margaret Chase Smith in her “Declaration of Conscience” speech. The author suggests that independent thought must be renewed continually and cultivated at every turn, or it becomes fixed ideology that cannot adapt to changing circumstances
[Recensione a:] Studies in Canadian Literature – Études en littérature canadienne, vol. 47, n. 1, 2022.
No full textLe numéro de la revue accueille trois articles qui concernent la littérature canadienne francophone
A journey among pairs of vertices: Computing Robots' paths for performing joint measurements
No full textThe problem of performing joint measurements recurs in many robotic applications, like constructing communication maps from signal strength samples gathered on the field. In spite of this, a theo ry supporting efficient algorithms has not been yet developed and ad hoc methods are usually employed. In this paper. we consider an environment represented by a metric graph and prove that the problem of Jointly performing measurements from given vertices is NP-hard when either the total traveled distance or the task comp letion time have to be minimized. Given the difficulty of finding optimal paths in an efficient way, we propose a greedy randomized approach able to cope with both the optimization objectives. In settings for which joint measurements must be taken for all pairs of vertices, we prove that a deterministic greedy algorithm achieves an O(m log n) approximation factor for the traveled distance object ive, where m is the number of robots and n the number of vertices, and an O(m2 log n) approximation factor for the completion time. Experiments in simulation show that our algorithms perform well in practice, also when compared to an ad hoc method taken from the literature
Linear arrector pili muscle hamartoma on the tail of a sphynx cat
No full textArrector pili muscle (APM) hamartoma is reported in humans and dogs. We describe a linear APM hamartoma in a sphynx cat. The lesion was characterized by multiple nodules distributed linearly along the tail, made of randomly arranged hypertrophic smooth muscles, the size of which tended to wax-and-wane during a one year follow-up
A journey among pairs of vertices: Computing Robots' paths for performing joint measurements
No full textThe problem of performing joint measurements recurs in many robotic applications, like constructing communication maps from signal strength samples gathered on the field. In spite of this, a theo ry supporting efficient algorithms has not been yet developed and ad hoc methods are usually employed. In this paper. we consider an environment represented by a metric graph and prove that the problem of Jointly performing measurements from given vertices is NP-hard when either the total traveled distance or the task comp letion time have to be minimized. Given the difficulty of finding optimal paths in an efficient way, we propose a greedy randomized approach able to cope with both the optimization objectives. In settings for which joint measurements must be taken for all pairs of vertices, we prove that a deterministic greedy algorithm achieves an O(m log n) approximation factor for the traveled distance object ive, where m is the number of robots and n the number of vertices, and an O(m2 log n) approximation factor for the completion time. Experiments in simulation show that our algorithms perform well in practice, also when compared to an ad hoc method taken from the literature
Uso della citometria a flusso nello studio delle popolazioni linfocitarie circolanti con particolare riferimento al ruolo dei linfociti T regolatori e in corso di dermatite atopica
No full textLa dermatite atopica rappresenta una delle patologie più frequenti in ambito
dermatologico canino. L’eziopatogenesi a oggi, come in umana, non è del
tutto compresa; si concorda che si tratti di una sindrome a eziologia multifattoriale,
dove influenze ambientali, genetiche e immunitarie concorrono a
innescare e perpetuare tale malattia. Ultimamente si è affermata l’ipotesi che
alla base dei disturbi immunitari ci sia un’alterata cascata di attivazione dei
linfociti T helper (Th) e nel particolare un’inadeguata funzionalità dei linfociti
regolatori (Treg). Un’alterazione della quantità e dei meccanismi soppressivi
di tali linfociti porterebbe a un disequilibrio del rapporto tra linfociti Th1
e Th2. La citofluorimetria, o citometria a flusso, è una metodica di laboratorio
che permette la valutazione qualitativa e quantitativa di diversi parametri
di singole cellule in sospensione. La quantificazione dei Treg con queste nuove
tecniche favorisce lo studio e la conoscenza della complessa cascata immunitaria
in corso di malattie allergiche.Canine atopic dermatitis (CAD) is one of the most common dermatologie diseases in dogs. Its etiopathogenesis is not completely clear; it is currently accepted that CAD is a multifactorial syndrome, where environmental, genetic and immunologicfactors play a role in development and progression of the disease. Recently, an abnormal activation and function of T helper (Th) contributor to immunologic dysfunction has been speculated. It is supposed that variations in number or function of Treg would lead to an altered relationship between Th1 and Th2 lymphocytes. This hypothesis would explain part of CAD etiopathogenesis. Flow cytometry is a technique that allows a qualitative and quantitative investigation of cells suspended in a solution. This technique can be used to study lympho-gtes populations, including Treg, to investigate the complex immune cascade in allergic diseases
Lymphocyte subpopulations and Treg cells in dogs with atopic dermatitis receiving ciclosporin therapy : a prospective study
No full textBackground: Canine atopic dermatitis (CAD) is a chronic dermatological disease partly due to dysregulation of the immune system. Inappropriate activation of CD4+ lymphocytes could favour and promote the allergic response. An inadequate activation system of regulatory T cells (Tregs) is suspected to be a key immunological feature of the allergic response in atopic dogs. Hypothesis/Objectives: To evaluate the difference in the CD4/CD8 lymphocyte ratio and the percentage of Tregs in healthy dogs, in a breed predisposed to CAD, and in dogs affected by CAD before and during therapy with ciclosporin (CsA). Additionally to assess the improvement in pruritus and skin lesions during therapy with CsA, and to compare this with CD4/CD8/Treg values. Animals: Ten atopic dogs of different breed, sex and age, ten healthy dogs and ten English bulldogs were included. Methods: Peripheral blood from all dogs was tested using flow cytometry to assess the CD4/CD8 ratio and percentage of Tregs. For atopic dogs, sampling was repeated after 30 and 90 days of therapy with CsA. Results: The CD4/CD8 ratio was not significantly different between the three groups. The Treg percentage was higher, but not statistically significant, in atopic dogs compared with controls. Therapy with CsA led to clinical improvement; it was not associated with statistically significant differences in haematological variables. Conclusion and clinical importance: This study suggests that Tregs may be involved in the pathogenesis of CAD and that ciclosporin therapy does not affect the circulating lymphocyte subpopulations
Chemoinformatics approaches for new drugs discovery
No full textChemoinformatics uses computational methods and technologies to solve chemical problems. It works on molecular structures, their representations, properties and related data. The first and most important phase in this field is the translation of interconnected atomic systems into in-silico models, ensuring complete and correct chemical information transfer. In the last 20 years the chemical databases evolved from the state of molecular repositories to research tools for new drugs identification, while the modern high-throughput technologies allow for continuous chemical libraries size increase as highlighted by publicly available repository like PubChem [http://pubchem.ncbi.nlm.nih.gov/], ZINC [http://zinc.docking.org/], ChemSpider[http://www.chemspider.
com/]. Chemical libraries fundamental requirements are molecular uniqueness, absence of ambiguity, chemical correctness (related to atoms, bonds, chemical orthography), standardized storage and registration formats. The aim of this work is the development of chemoinformatics tools and data for drug discovery process. The first part of the research project was focused on accessible commercial chemical space analysis; looking for molecular redundancy and in-silico models correctness in order to identify a unique and univocal molecular descriptor for chemical libraries indexing. This allows for the 0%-redundancy achievement on a 42 millions compounds library. The protocol was implemented as MMsDusty, a web based tool for molecular databases cleaning. The major protocol developed is MMsINC, a chemoinformatics platform based on a starting number of 4 millions non-redundant high-quality annotated and biomedically relevant chemical structures; the library is now being expanded up to 460 millions compounds. MMsINC is able to perform various types of queries, like substructure or similarity search and descriptors filtering. MMsINC is interfaced with PDB(Protein Data Bank)[http://www.rcsb.org/pdb/home/home.do] and related to approved drugs. The second developed protocol is called pepMMsMIMIC, a peptidomimetic screening tool based on multiconformational chemical libraries; the screening process uses pharmacophoric fingerprints similarity to identify small molecules able to geometrically and chemically mimic endogenous peptides or proteins. The last part of this project lead to the implementation of an optimized and exhaustive conformational space analysis protocol for small molecules libraries; this is crucial for high quality 3D molecular models prediction as requested in chemoinformatics applications. The torsional exploration was optimized in the range of most frequent dihedral angles seen in X-ray solved small molecules structures of CSD(Cambridge Structural Database); by appling this on a 89 millions structures library was generated a library of 2.6 x 10 exp 7 high quality conformers. Tools, protocols and platforms developed in this work allow for chemoinformatics analysis and screening on large size chemical libraries achieving high quality, correct and unique chemical data and in-silico model
Patons (Pattons) and Patton Fanton De Verrayons: Genealogy of Family
No full textВисвітлюється історія та реконструюється генеалогія роду Патонів, з
якого походить ціла плеяда видатних діячів – військовики (Петро Іванович
Патон, Петро Іванович Патон-Фантон-де-Веррайон, Микола Іванович Патон, Олександр Миколайович Патон), дипломат (Оскар Петрович Патон),
правники (Іван Петрович Патон, Оскар Миколайович Патон), архітектор
(Петро Юрійович Патон), земський і громадський діяч (Михайло Оскарович
Патон) та науковці (Євген Оскарович Патон, Володимир Євгенович Патон,
Борис Євгенович Патон, Євгенія Борисівна Патон). Використано переважно джерела офіційного походження з архівосховищ України та Росії, зокрема справи про дворянство, що містять величезну кількість матеріалів як власне генеалогічного, так і загального біографічного характеру. Усі документи мають високий рівень достовірності. Незважаючи на це, під час верифікації
інформації здійснювалося їх критичне осмислення та зіставлення з іншими джерелами.In the article the author highlights the history and reconstructs the genealogy of
the Patons, from which comes a whole galaxy of prominent figures – military (Petro
Ivanovych Paton, Petro Ivanovych Paton Fanton de Verrayon, Mykola Ivanovych
Paton, Oleksandr Mykolaiovych Paton), diplomat (Oskar Petrovych Paton), lawyers
(Ivan Petrovych Paton, Oskar Mykolaiovych Paton), architect (Petro Yuriiovych
Paton), public figure (Mykhailo Oskarovych Paton) and scientists (Yevhen Oskarovych
Paton, Volodymyr Yevhenovych Paton, Borys Yevhenovych Paton, Yevheniia Borysivna Paton). The author used the sources of official origin from the archives of Ukraine and Russia. They contain a huge amount of documents of the genealogical
and general biographical nature. All documents have a high level of reliability.
During the verification of the information, their critical thinking was carried out and a comparison with other sources
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