2,652 research outputs found
Innovative treatments for severe refractory asthma: how to choose the right option for the right patient?
No full textFrancesco Menzella,1 Carla Galeone,1 Francesca Bertolini,2 Claudia Castagnetti,1 Nicola Facciolongo1 1Department of Medical Specialties, Pneumology Unit, IRCCS- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 2Department of Animal Science, Iowa State University, Ames, IA, USA Abstract: The increasing understanding of the molecular biology and the etiopathogenetic mechanisms of asthma helps in identification of numerous phenotypes and endotypes, particularly for severe refractory asthma. For a decade, the only available biologic therapy that met the unmet needs of a specific group of patients with severe uncontrolled allergic asthma has been omalizumab. Recently, new biologic therapies with different mechanisms of action and targets have been approved for marketing, such as mepolizumab. Other promising drugs will be available in the coming years, such as reslizumab, benralizumab, dupilumab and lebrikizumab. Moreover, since 2010, bronchial thermoplasty has been successfully introduced for a limited number of patients. This is a nonpharmacologic endoscopic procedure which is considered a promising therapy, even though several aspects still need to be clarified. Despite the increasing availability of new therapies, one of the major problems of each treatment is still the identification of the most suitable patients. This sudden abundance of therapeutic options, sometimes partially overlapping with each other, increases the importance to identify new biomarkers useful to guide the clinician in selecting the most appropriate patients and treatments, without forgetting the drug-economic aspects seen in elevated direct cost of new therapies. The aim of this review is, therefore, to update the clinician on the state of the art of therapies available for refractory asthma and, above all, to give useful directions that will help understand the different choices that sometimes partially overlap and to dispel the possible doubts that still exist. Keywords: severe asthma, phenotypes, monoclonal antibodies, IL-5, bronchial thermoplasty, biomarker
Bertolini (Gérard) - Rebuts ou ressources ? La socio-économie du déchet.
No full textPlauchu Vincent. Bertolini (Gérard) - Rebuts ou ressources ? La socio-économie du déchet.. In: Revue économique, volume 31, n°4, 1980. p. 789
Le balai ou les ratées du progrès
No full textGérard Bertolini, Der Besen oder die Fehler des Fortschritts
Die Mechanisierung der Stradtreinigung ist zu weit gegangen. In letzter Instanz leistet der Besen bessere Dienste, und were ihn schwingt, verdient mehr Respekt.Gérard Bertolini, The broom, or progress' losers
In spite of the mécanisation of everything including cleaning, a broom is still useful as a last resort, and scorn for the woman who wields it still exists.Malgré la mécanisation y compris du nettoyage, le balai est toujours utile en dernière instance, et le mépris pour celle qui le tient toujours d'actualité.Gérard Bertolini, La escoba o los fallos del progreso
A pesar de la mecanización de la limpieza, la escoba sigue siendo útil en ultima instantia, y el desprecio por quien la utiliza sigue siendo de actualidad.Bertolini Gérard. Le balai ou les ratées du progrès. In: Les Annales de la recherche urbaine, N°53, 1991. Le génie du propre. pp. 89-91
Holographic Projection of Electromagnetic Maxwell Theory
No full textThe 4D Maxwell theory with single-sided planar boundary is considered. As a consequence of the presence of the boundary, two broken Ward identities are recovered, which, on-shell, give rise to two conserved currents living on the edge. A Kaç-Moody algebra formed by a subset of the bulk fields is obtained with central charge proportional to the inverse of the Maxwell coupling constant, and the degrees of freedom of the boundary theory are identified as two vector fields, also suggesting that the 3D theory should be a gauge theory. Finally the holographic contact between bulk and boundary theory is reached in two inequivalent ways, both leading to a unique 3D action describing a new gauge theory of two coupled vector fields with a topological Chern-Simons term with massive coefficient. In order to check that the 3D projection of 4D Maxwell theory is well defined, we computed the energy-momentum tensor and the propagators. The role of discrete symmetries is briefly discussed
Gérard Bertolini, Du balai ou Les ratés du progrès
No full textde Souza Philippe. Gérard Bertolini, Du balai ou Les ratés du progrès. In: Les Annales de la recherche urbaine, N°28, 1985. Pouvoirs locaux. p. 153
An unexpected encounter: educational science and psychoanalysis in the phenomenological pedagogy of Piero Bertolini
No full textThe present paper offers a reflection on the interconnections between pedagogy and psychoanalysis as interpreted in the phenomenological pedagogy of Piero Bertolini. Interest in the topic is justified by the fact that throughout his work (especially in Bertolini, 1988; 2005) this author himself repeatedly argued for the existence of such links. In the current paper, I outline and analyse some key points of intersection between phenomenological pedagogy and the psychoanalytical perspective. Specifically, I examine the theoretical bases justifying a comparison of these two sciences, the core thematic affinities between them, and finally the implications for the practice of phenomenological pedagogy that arise from this interdisciplinary encounter
Topological BF Description of 2D Accelerated Chiral Edge Modes
No full textIn this paper, we consider the topological abelian BF theory with radial boundary on a generic 3D manifold, as we were motivated by the recently discovered accelerated edge modes on certain Hall systems. Our aim was to research if, where, and how the boundary keeps the memory of the details of the background metrics. We discovered that some features were topologically protected and did not depend on the bulk metric. The outcome was that these edge excitations were accelerated, as a direct consequence of the non-flat nature of the bulk spacetime. We found three possibilities for the motion of the edge quasiparticles: same directions, opposite directions, and a single-moving mode. However, requiring that the Hamiltonian of the 2D theory is bounded by below, the case of the edge modes moving in the same direction was ruled out. Systems involving parallel Hall currents (for instance, a fractional quantum Hall effect with ν=2/5) cannot be described by a BF theory with the boundary, independently from the geometry of the bulk spacetime, because of positive energy considerations. Thus, we were left with physical situations characterized by edge excitations moving with opposite velocities (for example, the fractional quantum Hall effect with ν=1−1/n, with the n positive integer, and the helical Luttinger liquids phenomena) or a single-moving mode (quantum anomalous Hall). A strong restriction was obtained by requiring time reversal symmetry, which uniquely identifies modes with equal and opposite velocities, and we know that this is the case of topological insulators. The novelty, with respect to the flat bulk background, is that the modes have local velocities, which correspond to topological insulators with accelerated edge modes
A note on the dual of N=1 super-Yang–Mills theory
No full textAbstractWe refine the dictionary of the gauge/gravity correspondence realizing N=1 super-Yang–Mills by means of D5-branes wrapped on a resolved Calabi–Yau space. This is done by fixing an ambiguity on the correct interpretation of the holographic dual of the running gauge coupling and amounts to identify a specific 2-cycle in the dual ten-dimensional supergravity background. In doing so, we also discuss the role played in this context by gauge transformations in the relevant seven-dimensional gauged supergravity. While all nice properties of the duality are maintained, this modification of the dictionary has some interesting physical consequences and solves a puzzle recently raised in the literature. In this refined framework, it is also straightforward to see how the correspondence naturally realizes a geometric transition
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