4 research outputs found
Hematologic indices as an available tool in the diagnosis of adverse course of COVID-19
Get PDFAim. To study the prognostic significance of hematologic indices: neutrophils/lymphocytes (N/L), platelets/lymphocytes (P/L) and lymphocytes/C-reactive protein (L/CRP) in relation to the complicated course of new coronavirus infection (COVID-19), as well as their correlation with COVID-19 course severity indices and endothelial dysfunction marker sVCAM-1.
Materials and methods. 103 patients with new coronavirus infection (COVID-19) were included in the study. Based on the data of multispiral computed tomography (CT) of the chest organs, all patients were divided into 3 groups: CT group 1 – 30 patients, CT group 2 – 62 patients and CT group 3 – 11 patients.
Results. The values of N/L and P/L were significantly higher in patients of CT group 3 compared to patients of CT group 1 and CT group 2. L/CRP index, on the contrary, significantly decreased with increasing CT-degree of lung lesion. The concentration of endothelial dysfunction marker sVCAM-1 was significantly higher in patients of CT-3 and 2 groups compared to patients of CT-1 group – 272.7 [267.4; 342.6] ng/mL and 212.5 [90.3; 335.6] ng/mL vs 120.0 [75.3; 189.2] ng/mL. Significant correlations of the studied hematologic indices with clinical, laboratory and instrumental characteristics of COVID-19 severity were found. P/L and L/CRP indices were associated with sVCAM-1 concentration in blood (r=0.28 and -0.33 respectively; p0.05). The values of N/L2.53 and L/CRP≤0.043 are predictors of the development of cytokine storm in the examined patients.
Conclusion. Hematologic indices N/L, P/L and L/CRP are correlated with clinical, laboratory and instrumental characteristics of COVID-19 severity, presence of endothelial dysfunction (P/L and L/CRP) and allow predicting the development of cytokine storm (N/L and L/CRP)
Comparative effects of different supplemented dietary doses of chlorophyll on blood parameters of experimental male rats
Get PDFAbstract Chlorophylls are organic pigments that are a part of our daily diet, particularly in light of the increased popularity of more eco-friendly and healthy practices. Since altering oxidative equilibrium seems to be connected to the emergence of numerous illnesses, the antioxidant capacities of both groups of lipophilic compounds have been studied. The objective was to evaluate adding dietary chlorophyll at two concentrations—30 and 60 mg/ml—would improve blood characteristics in rats. Supplemented dietary chlorophyll showed significantly increased WBCs, RBCs, granulocytes, lymphocytes, HGB, HCT MCHC, and Platelets. it nonsignificant effect on RDW, MPV, and Eosinophil. These findings support a significant rise in critical hematological parameters at two separate time intervals, 14 and 28 days following dietary chlorophyll supplementation, at dosages of 30 and 60 mg/ml. After 30 and 60 mg/ml, platelet count, PCT, lymphocytes, and monocytes substantially (p0.001) rose. In light of these findings, critical hematological indicators markedly rise in response to exogenous dietary chlorophyll. To strengthen blood parameters and enhance blood features and prevent anemia, dietary chlorophyll is advised
Ждут ли университеты выпускников средних профессиональных образовательных учреждений?
Get PDFIntroduction. Within the framework of the methodology of modern vocational education, the article examines the transformation of communication campaigns of universities to attract applicants after colleges and technical schools. Purpose setting. The main problem of communication campaigns of higher educational institutions is insufficient attention to narrower segments of applicants, especially college and technical school graduates. Methodology and methods of the study. It is reasoned that college graduates have different needs and values, hence the focus of attention of the communication campaign should also be different. Results. After the analysis, some shortcomings in communication campaigns aimed at college graduates become apparent: for example, the lack of a full-fledged communication campaign as such, the lack of information necessary for full enrollment on some college websites, the lack of «college representatives» who visit colleges in person and talk about their college. Conclusion. Measures were proposed to improve the communication campaign of higher educational institutions to attract applicants entering on the basis of secondary vocational education.Введение. В рамках методики современного профессионального образования в статье рассматривается трансформация коммуникационных кампаний вузов по привлечению абитуриентов после колледжей и техникумов. Постановка задачи. Основной проблемой коммуникационных кампаний вузов является недостаточное внимание к более узким сегментам поступающих, в особенности выпускникам колледжей и техникумов. Методика и методология исследования. Обосновывается, что у выпускников колледжей иные потребности и ценности, следовательно, фокусы внимания коммуникационной кампании должны отличаться. Результаты. Анализ позволил выявить некоторые недостатки коммуникационных кампаний, направленных на привлечение выпускников коллежей: например, отсутствие полноценной коммуникационной кампании как таковой, отсутствие необходимой для полноценного поступления информации на сайтах некоторых вузов, отсутствие «представителей вузов», которые очно посещают колледжи и рассказываю о своем вузе. Выводы. Предложены меры по улучшению коммуникационной кампании вузов по привлечению абитуриентов, поступающих на базе среднего профессионального образования
Нимесулид при ревматоидном артрите
Get PDFMany patients with rheumatoid arthritis (RA) continue symptomatic treatment with anesthetics despite the progress in treating this disease, which is associated with improved methods for its early diagnosis and pathogenetic therapy. Nonsteroidal anti-inflammatory drugs (NSAIDs) remain a main class of analgesics used in RA. NSAIDs are an important component of RA treatment and should be administered in all cases of joint pain. Their administration at disease onset and in undifferentiated arthritis when carrying out a diagnostic search and selecting a concept of use of disease-modifying antirheumatic drugs (DMARDs) is of basic importance. NSAID therapy reduces patients’ distress and quality of life before DMARDs show their activity, considerably reduce disease activity, and relieve pain. This review considers the important aspects of using NSAIDs in RA. Nimesulide is one of the most popular NSAID representatives; its advantages and disadvantages are shown; particular emphasis is placed on its safety. Analysis of the data available in the literature has shown that the hepatotoxicity of nimesulide is not higher than that of many other representatives of the NSAID class. Although the fact that nimesulide may be responsible for menacing cardiovascular events is being investigated, none of the recent large trials of nimesulide has recorded a significant increase in the rate of cardiovascular events during its long-term use.У многих больных ревматоидный артритом (РА) сохраняется потребность в приеме симптоматических обезболивающих препаратов, несмотря на успехи в лечении этого заболевания, связанные с совершенствованием методов его ранней диагностики и патогенетической терапии. Основным классом анальгетиков, используемых при РА, остаются нестероидные противовоспалительные препараты (НПВП). НПВП являются важным компонентом лечения РА и должны применяться во всех случаях суставной боли. Особое значение имеет их назначение в дебюте болезни и при недифференцированном артрите, когда ведется диагностический поиск и выбирается концепция применения базисных противовоспалительных препаратов (БПВП). Терапия НПВП уменьшает страдания и улучшает качество жизни больных до того момента, когда проявится действие БПВП и будет достигнуто значительное снижение активности болезни, в том числе исчезновение боли. В настоящем обзоре рассмотрены важные аспекты применения НПВП при РА. Одним из наиболее популярных представителей НПВП является нимесулид, представлены достоинства и недостатки, этого препарата, особое внимание уделено проблеме его безопасности. Как показал анализ данных литературы, гепатотоксичность нимесулида не выше, чем у многих других представителей класса НПВП. Хотя проблема развития опасных кардиоваскулярных осложнений при использовании нимесулида продолжает изучаться, ни в одном из крупных исследований нимесулида, проведенных в последнее время, не зафиксировано значимого повышения частоты кардиоваскулярных осложнений на фоне его длительного приема
