69 research outputs found
Conservative treatment of partial rotator cuff tears, comparison between infiltrative treatment with corticosteroids, medium molecular weight hyaluronic acid and high molecular weight hyaluronic acid: a prospective study
No full textThe canaries, op. 10 [music] : valse de concert for the pianoforte with violin solo /
No full textCover title.; "Dedicated by kind permission to Lady Downer" --Cover.; Also available online http://nla.gov.au/nla.mus-an5210953; N, MUS/042
Peripheral longitudinal acute meniscal lesion: conservative treatment based on medium molecular weight hyaluronic acid
No full textConservative treatment of hip osteoarthritis; comparison between three medium/high molecular weight hyaluronic acid injections and two injections of hyadd®4: A randomized controlled double-blind study
No full textArthroscopic surgery or exercise therapy for degenerative meniscal lesions: a systematic review of systematic reviews
Get PDFBackground: Arthroscopic partial meniscectomy (APM) is widely applied for the treatment of degenerative meniscal lesions in middle-aged patients; however, such injury is often associated with mild or moderate osteoarthritis and has been reported by MRI in asymptomatic knees. Previous studies suggested, in most patients, a lack of benefit of surgical approach over conservative treatment, yet many controversies remain in clinical practice. Our aims were to assess the functional and pain scores between exercise therapy and arthroscopic surgery for degenerative meniscal lesions and to evaluate the methodological quality of the most recent systematic reviews (SRs).Methods: Two authors independently searched PubMed and Google Scholar for SRs comparing the outcome (in knee pain and functionality) of arthroscopic treatment and exercise therapy or placebo for degenerative meniscal lesions. The timeframe set was from 2009 to 2019 included.Results: A total of 13 SRs were selected. Two reviewers independently assessed the methodological quality of each paper using the AMSTAR 2 tool: seven scored as "moderate," four obtained a "low" grade while the remaining two were evaluated as "critically low." SRs agreed that in middle-aged patients with degenerative meniscal lesions arthroscopic surgery appears to grant no long-term improvement in pain and function over exercise therapy or placebo.Conclusions: Conservative treatment based on physical therapy should be the first-line management. However, most SRs revealed subgroups of patients that fail to improve after conservative treatment and find relief when undergoing surgery. In the future, randomized controlled trials, evidence should be looked for that APM can be successful in case of the unsatisfactory results after physical therapy
Mason type III fractures of the radial head: ORIF, resection or prosthetic replacement?
No full textPurpose: This study focused on a comparison of mid-term clinical, functional and radiographic outcomes of adults treated by open reduction and internal fixation (ORIF), radial head prosthesis (RHP) and resection (RHR). Methods: The retrospective evaluation concerned 47 surgically treated patients after a mean follow-up of 53 months. All patients were grouped according to the surgical procedure performed: 15 in the RHP group, 16 in the ORIF group and 16 in the RHR group. At the follow-up, outcome assessment was based on radiographs, range of motion (ROM) and functional rating scores. Results: Patients treated by RHR had significantly higher mean age and shorter operation time than other two groups. Compared to ROM, flexion, extension and pronation were significantly worse in patients treated by ORIF than those in the RHP group and the RHR group. Supination was significantly better in the RHP group. However, no statistical differences were observed in functional rating scores among the three groups. Regarding complications, instability was the only cause of revision surgery in the RHP group and the RHR group. On the other hand, the ORIF group revision rate was 50% and secondary displacement was the most frequent cause of failure. Conclusion: The ORIF group did not show good results with greater elbow stiffness and higher revision rate than the other two techniques. RHR may be suitable for elderly patients with lower functional demands as it reported good clinical results and reduced operation time
Identification of black sturgeon caviar pigment as eumelanin
No full textReported herein is the purification of the pigment of black sturgeon caviar and its unambiguous identification as a typical eumelanin by means of chemical degradation coupled with electron paramagnetic resonance (EPR) evidence. HPLC and LC-MS analysis of oxidative degradation mixtures revealed the formation of pyrrole-2,3,5-tricarboxylic acid (PTCA), a specific marker of eumelanin pigments, in yields compatible with a 6.5% w/w pigment content. EPR spectral features and parameters were in close agreement with those reported for a typical natural eumelanin such as Sepia melanin from squid ink. The identification for the first time of eumelanin in a fish roe is expected to provide a novel molecular basis for the valorization of black caviar and production wastes thereof in food chemistry and diet
Opto-mechanical effects in nematic and cholesteric liquid crystals
No full textIl lavoro si inserisce in un programma di ricerca teso a mettere in evidenza alcuni fenomeni termodinamici di non equilibrio proibiti per ragioni di simmetria nei materiali normali, ma permessi nei materiali chirali. Questi fenomeni coinvolgono l’accoppiamento tra una forza termodinamica di tipo polare e un flusso di tipo assiale. La relativa costante di accoppiamento è quindi uno pseudo-scalare. Si tratta, in generale, di effetti molto deboli e difficili da rivelare, poiché il grado di chiralità dei materiali formati da molecole chirali è, in genere, molto piccolo. I cristalli liquidi colesterici, invece, possiedono una chiralità di tipo strutturale, che è molti ordini di grandezza più grande della chiralità di origine molecolare e sono quindi materiali ideali per l’osservazione sperimentale di tali effetti. Il più noto tra gli effetti termodinamici legati alla chiralità dei colesterici è l’effetto Lehman, che è l’oggetto di studio di questo lavoro. L’effetto consiste nella rotazione della struttura colesterica indotta dall’applicazione di un gradiente di temperatura o di un campo elettrostatico. Sebbene il fenomeno sia stato osservato al microscopio da Lehman fin dal 1900, ogni tentativo di misura quantitativa è finora fallito, per via di effetti concomitanti, come l’effetto flesso-elettrico, legati al difficile controllo della geometria sperimentale (usualmente micro-gocce di colesterico in ambiente isotropo). L’idea di base del lavoro è quello di utilizzare un fascio di luce focalizzato per creare la “gocciolina” colesterica in un ambiente nematico che abbia una simmetria cilindrica attorno alla direzione della velocità angolare di rotazione indotta. La luce svolge un ruolo puramente ausiliario, che permette, però, il controllo accurato della geometria del profilo colesterico, in modo da poter escludere gli effetti concorrenti
Le voci dei matti. Il ritrovamento dell'archivio sonoro di Anna Maria Bruzzone
No full textThe paper presents the discovering of an oral archive. Anna Maria Bruzzone’s book Ci chiamavano matti. Voci da un ospedale psichiatrico (Einaudi, Torino 1979) contains the testimonies of thirty-seven patients of the Arezzo psychiatric hospital collected in 1977. The book testimonies the patients’ miserable lives inside and outside the hospital and sheds light on the atrocity of their everyday condition by letting them speak for themselves. The author wrote it after a two-month stay in Arezzo, when she spent almost every day in the hospital, attending the general meetings and participating to the lives of the inpatients, in a continuous dialogue of which only a part is collected in the published interviews. The oral recordings on which the book is based were believed to be lost forever. After long and strenuous search I have been able to locate the original tapes. Such discovery is of great magnitude, because the digitisation and cataloguing of this archive would produce the first digital oral archive related to an Italian psychiatric hospital – which was located in the same buildings of my Department (Department of Educational Sciences, Human Sciences and Intercultural Communication of the University of Siena – Arezzo) where also the Historical Archive of the Arezzo psychiatric hospital is hosted
Shallow Whole Genome Sequencing (sWGS) pipeline for the assessment of Homologous Recombination Deficiency (HRD) score in Hereditary Breast and Ovarian Cancer (HBOC) patients
No full textIntroduction: the Homologous Recombination Repair (HRR) system is essential for DNA repair and genomic stability. Homologous Recombination Deficiency (HRD) arises upon the inactivation of several genes involved in HRR, and it is commonly observed in breast and ovarian cancer. The detection of HRD is a valuable tool of clinical relevance, indicative of sensitivity to agnostic therapy and DNA damaging reagents. Methods: shallow Whole Genome Sequencing (sWGS) was performed on 26 ovarian cancer (OC) samples divided into training (n=13) and test group (n=13). The training set included 7 somatic and 6 germline carrying BRCA+ve (n=8) and BRCA-ve (n=5) status. In particular, the BRCA+ve were 3/7 somatic and 5/6 germline samples; the BRCA-ve were 4/7somatic and 1/6 germline. All samples were prepared using the KAPA HyperPlus Library Preparation kit (Roche), pooled and sequenced on NextSeq550 Dx (Illumina). Large-Scale Transitions (LST) profiles were calculated using WGS data at low coverage (<1x) using different sliding window sizes spanning 10-1 000 Kbases. The HRD score was estimated using our bioinformatics pipeline. Results: the BRCA status was assessed in 22/26 OC samples, and the HRD score was evaluated in all somatic samples. In the test group, 7 BRCA+ve samples were classified as HRD+ve, 2 BRCA-ve were classified as HRD-ve, and 4 BRCA unknown samples were predicted as HRD+ve in two cases and HRD-ve in the other half. Discussion: germline BRCA1/2 mutation status is currently the main genetic biomarker of HRD, but it has its drawbacks: HRD can be driven purely by somatic events. A bioinformatics pipeline to evaluate the HRR system status in breast and ovarian cancer has been completed; it is based on sWGS to support therapeutics and follow up strategies
- …
