4,577 research outputs found
Utilizing biomarkers in colorectal cancer: an interview with Ajay Goel
No full text Ajay Goel speaks to Rachel Jenkins, Commissioning Editor. Ajay Goel, PhD, is a Professor and Director, Center for Gastrointestinal Research, and Director, Center for Translational Genomics and Oncology, at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, Texas. Dr Goel has spent more than 20 years researching cancer and has been the lead author or contributor to over 240 scientific articles published in peer-reviewed international journals and several book chapters. He is also a primary inventor on more than 15 international patents aimed at developing various biomarkers for the diagnosis, prognosis and prediction of gastrointestinal cancers. He is currently using advanced genomic and transcriptomic approaches to develop novel DNA- and miRNA-based biomarkers for the early detection of colorectal cancers. In addition, he is researching the prevention of gastrointestinal cancers using integrative and alternative approaches, including botanical products such as curcumin (from turmeric) and boswellia. Dr Goel is a member of the American Association for Cancer Research (AACR) and the American Gastroenterology Association (AGA) and is on the international editorial boards of several journals including Gastroenterology, Clinical Cancer Research, Carcinogenesis, PLoS ONE, Scientific Reports, Epigenomics, Future Medicine, Alternative Therapies in Heath and Medicine and World Journal of Gastroenterology. He is also actively involved in peer-reviewing activities for more than 100 international scientific journals and various grant review panels of various national and international funding organizations. His research has been actively funded by various private and federal organizations, including funding from the National Cancer Institute (NCI) at the NIH, American Cancer Society (ACS) and other state organizations. He has won more than dozen awards and honors, including the Union of European Gastroenterology Federation's Distinguished Researcher Award, multiple Poster of Distinction Awards from the AGA, and Visiting Professorships from various national and international academic institutions and academic bodies. Some of his key research interests include: Understanding the basic genetics and epigenetic basis of gastrointestinal cancers; Use of epigenetic markers, both DNA and RNA, for the early detection of colorectal, pancreatic and other gastrointestinal cancers; Personalized medicine and treatment of gastrointestinal cancers; Chemoprevention, using complementary and alternative approaches using nutraceuticals such as curcumin, green tea, resveratrol and other botanicals. </jats:p
Alternative technique of cervical spinal stabilization employing lateral mass plate and screw and intra-articular spacer fixation
No full textAim: The author discusses an alternative technique of segmental cervical spinal fixation. Material and Methods: The subtleties of the technique are discussed on the basis of experience with 3 cases with a follow-up of between 30 and 36 months. Technique: The technique involves debridement of facetal articular cartilage, distraction of facets, jamming of ′Goel spacer′ into the articular cavity and fortification of the fixation by lateral mass plate and screw fixation. The ′double-insurance′ method of fixation is safe for vertebral artery, nerve roots and spinal neural structures and the fixation is strong. Conclusions: The discussed technique is safe and provides a strong fixation and a ground for ultimate arthrodesis
Author Reply Re: Goel A. Research training during residency. Indian J Urol 2017;33:257-8
No full textAlkali-free bioactive glass composition, U.S. Patent 9,238,044
No full textThe present invention relates to development of bioactive glass/glass-ceramic composition that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (SBF) for time periods as short as one hour. Such composition might include fluorides, and a variety of oxides (or their precursor compounds), such as Na2O—Ag2O—SrO—CaO—MgO—ZnO—P2O5—SiO2—Bi2O3—B2O3—CaF2, be prepared by the melt route or by the sol-gel process, with the specific composition and the preparation route selected according to the intended functionalities, which can present controlled biodegradation rate and bactericidal activity. The powders derived from glass melts purred in cold water (frits) may completely densify by sintering at temperatures up to 800° C. without devitrification, resulting in bioglass compacts with high flexural strength (˜85 MPa). The bioactive glass powders prepared by sol-gel densify at lower temperatures due to their higher specific surface area and reactivity
Dimensions of civic activism and their effectiveness in exposing corruption: evidence from Italy
No full textThis article studies the influence of civic activism in exposing corruption across Italian regions.
Using different dimensions of civic activism (including local and national newspapers, the internet, blood donors, and voter turnout), we make the distinction between active (media, internet, voters) and passive (blood donors) activism. Results show interesting different impacts of civic activism on corruption. In particular, voter turnout, blood donors, and national newspaper diffusion consistently increased exposure of corruption, while the internet and local newspapers
showed opposite effects. Thus, local newspapers and the internet point to the possibility of media capture (influence) with regard to corruption exposure. The main findings hold following the substantial reforms in the nineties (called Mani Pulite)
From Tainted to Sainted: the Interracial Marriage as Cultural Evangelism
No full textThe article talks about interracial relationships viewed as cultural evangelism. The author mentions that viewing interracial marriage as the ultimate indicator of racial progress leaves the cognitive imprint that underlies all race relations. Professor Goel introduces the four archetypes of interracial relations that emanated from the four historical institutions such as the Civilized White and Colored Savage, the White Colonizer and Colored Subject, the White Master and Colored Slave, and the White Missionary and Colored Heathen. An analysis of the social and legal aspects of interracial marriages and interracial families is also presented
Community-based organisations: role in settling immigrants
No full textIt has been well acknowledged in the literature that successful settlement of new arrivals (both international and interstate) and their families is crucial for theirintegration and well-being in a host society. This will also result in population sustainability and meetingindustry requirements in regional areas. This chapter posits that community-based organisations (CBOs) are in a unique position to provide settlement services which are socially inclusive and evolve community participation under immigration department policy guidelines. Thechapter illustrates how a community development approach is a useful theory/constructto guide the practice of a community-based organisation that isproviding settlement services to new immigrants. This is demonstrated by using a case study of the 'Settling our Future' program provided through one of the community-basedorganisations in aregional city of South Australia.The author demonstrates that community development principles and approaches are the backbone of providing effective servicesto meet the needs of new arrivals in the regional town. The chapterfurther examines the role of the community development worker as a facilitator in establishing, developing and sustaining these initiatives which have a community basis
Author Reply Re: Goel A. Research training during residency. Indian J Urol 2017;33:257-8
No full textA new India: Contestations of national identity at the crossroads of postcolonial aspirations and globalized imagination
No full textMy dissertation examines contestations of national identity and representation of individual aspirations within a globalized imagination of 21st century India. In analyzing the metaphoric construction of a New India, I look at the unrestrained urbanization that has followed economic liberalization and the political mobilization of marginalized sections of the population, also concomitantly emerging within these new urbanscapes. As they intersect with new media practices, community-building and neoliberal restructuring of the state, enterprise and the individual, the tenor of a national community, previously invested in the narrative of a glorious past emerging from classical Hindu roots seem to be merging with myriad flows of globalization, transforming the social landscape of the postcolonial nation in significant ways. In studying this, my study uses archival data and ethnographic research to adopt a critical approach to communication and cultural studies with a focus on exploring how the country’s national imagination has been formed within the coordinates of the original Nehruvian trope of the nation as “a new star… of freedom in the East” and the newest construction of “India rising,” especially as it develops with relation to conditions of globalization. It examines how globalization has reconstituted the image of the nation, the national community and national prosperity, as well as development and progress – national, regional and individual – in the minds of the ordinary citizen.Item withdrawn by Alexis Thompson ([email protected]) on 2014-04-25T13:11:04Z
Item was in collections:
University of Illinois Theses & Dissertations (ID: 1)
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Perfect Matchings in O(n log n) Time in Regular Bipartite Graphs
No full textIn this paper we consider the well-studied problem of finding a perfect matching in a d-regular bipartite graph on 2n nodes with m = nd edges. The best-known algorithm for general bipartite graphs (due to Hopcroft and Karp) takes time O(m√n). In regular bipartite graphs, however, a matching is known to be computable in O(m) time (due to Cole, Ost, and Schirra). In a recent line of work by Goel, Kapralov, and Khanna the O(m) time bound was improved first to Ō(min{m, n2.5/d}) and then to Ō(min{m, n²/d}). In this paper, we give a randomized algorithm that finds a perfect matching in a d-regular graph and runs in O(n log n) time (both in expectation and with high probability). The algorithm performs an appropriately truncated alternating random walk to successively find augmenting paths. Our algorithm may be viewed as using adaptive uniform sampling, and is thus able to bypass the limitations of (nonadaptive) uniform sampling established in earlier work. Our techniques also give an algorithm that successively finds a matching in the support of a doubly stochastic matrix in expected time O(n log² n), with O(m) pre-processing time; this gives a simple O(m+mnlog² n) time algorithm for finding the Birkhoff-von Neumann decomposition of a doubly stochastic matrix. We show that randomization is crucial for obtaining o(nd) time algorithms by establishing an Ω(nd) lower bound for deterministic algorithms. We also show that there does not exist a randomized algorithm that finds a matching in a regular bipartite multigraph and takes o(n log n) time with high probability
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