77 research outputs found
PROPOSED PRODUCT STRATEGY BASED ON CONSUMER PREFERENCE FOR FASHION HIJAB BRAND (CASE STUDY: HUMAIRA LABEL)
No full textMuslim fashion industry has emerged to develop in Indonesia and considerable potential to become the center of the world's Muslim fashion according to Muslim fashion consumption estimated at US $20 billion with growth rate of 18.2 % per year in Indonesia (Global Islamic Report, 2018/2019). Humaira Label is a local brand of self manufactured Scarf and Woman Muslim Wear that aims to create modest, smart casual, exclusivity and unique scarf design with premium quality based on Bandung, established in August 2018. The raw material of Humaira Label built by natural fabrics, such as lyocell, cotton voile, miracle voile and ultrafine voile with various of beautiful unique design. The motif/design of scarves is exclusive because Humaira Label changes the design dynamically every batch. Its inspired by the lifestyle of dynamic and active working women in style - smart casual.This research aims to propose product strategy based on consumer preference by determining the cause of instability income of Humaira Label which is indicated by no sales indicate in several months by using internal and external factors analysis to find the root problems using STP, Marketing Mix Analysis, Porters Five and PEST Analysis, customer analysis and benchmark analysis and then been concluded in SWOT analysis and TOWS matrix. To know the customer preference toward hijab product, conducted the questionnaire by 103 respondents by analyzing the descriptive analysis and conjoint analysis.From matrix TOWS analysis, author proposed several alternative product strategies that can be implemented by Humaira Label. Those alternatives product strategy based on consumer preference that had been chosen to be proposed are making variance of product, improving promotion placement in social media, empowering local brand by creating brand value, reseller and drop shipper program, collaborate with social influencer in media social, and develop customer engagement program.Keywords:Muslim Fashion industry, Hijab, Product Strategy, Consumer Preference, TOWS matri
PROPOSED PRODUCT STRATEGY BASED ON CONSUMER PREFERENCE FOR FASHION HIJAB BRAND (CASE STUDY: HUMAIRA LABEL)
No full textMuslim fashion industry has emerged to develop in Indonesia and considerable potential to become the center of the world's Muslim fashion according to Muslim fashion consumption estimated at US $20 billion with growth rate of 18.2 % per year in Indonesia (Global Islamic Report, 2018/2019). Humaira Label is a local brand of self manufactured Scarf and Woman Muslim Wear that aims to create modest, smart casual, exclusivity and unique scarf design with premium quality based on Bandung, established in August 2018. The raw material of Humaira Label built by natural fabrics, such as lyocell, cotton voile, miracle voile and ultrafine voile with various of beautiful unique design. The motif/design of scarves is exclusive because Humaira Label changes the design dynamically every batch. Its inspired by the lifestyle of dynamic and active working women in style - smart casual.This research aims to propose product strategy based on consumer preference by determining the cause of instability income of Humaira Label which is indicated by no sales indicate in several months by using internal and external factors analysis to find the root problems using STP, Marketing Mix Analysis, Porters Five and PEST Analysis, customer analysis and benchmark analysis and then been concluded in SWOT analysis and TOWS matrix. To know the customer preference toward hijab product, conducted the questionnaire by 103 respondents by analyzing the descriptive analysis and conjoint analysis.From matrix TOWS analysis, author proposed several alternative product strategies that can be implemented by Humaira Label. Those alternatives product strategy based on consumer preference that had been chosen to be proposed are making variance of product, improving promotion placement in social media, empowering local brand by creating brand value, reseller and drop shipper program, collaborate with social influencer in media social, and develop customer engagement program.Keywords:Muslim Fashion industry, Hijab, Product Strategy, Consumer Preference, TOWS matri
A novel MAG variant causes hereditary spastic paraplegia in a consanguineous Pakistani family
No full textBackground and objectives: Hereditary spastic paraplegia (HSP) is characterized by unsteady gait, motor incoordination, speech impairment, abnormal eye movement, progressive spasticity and lower limb weakness. Spastic paraplegia 75 (SPG75) results from a mutation in the gene that encodes myelin associated glycoprotein (MAG). Only a limited number of MAG variants associated with SPG75 in families of European, Middle Eastern, North African, Turkish and Palestinian ancestry have been documented so far. This study aims to provide further insight into the clinical and molecular manifestations of HSP.Methods: Using whole-exome sequencing, we investigated a consanguineous Pakistani family where three individuals presented with clinical signs of HSP. Sanger sequencing was used to carry out segregation analysis on available family members, and a minigene splicing assay was utilized to evaluate the effect of the splicing variant.Results: We identified a novel homozygous pathogenic splice donor variant in MAG (c.46 + 1G \u3e T) associated with SPG75. RNA analysis revealed exon skipping that resulted in the loss of a start codon for ENST00000361922.8 isoform. Affected individuals exhibited variable combinations of nystagmus, developmental delay, cognitive impairments, spasticity, dysarthria, delayed gait and ataxia. The proband displayed a quadrupedal stride, and his siblings experienced frequent falls and ataxic gait as one of the prominent features that have not been previously reported in SPG75.Conclusions: Thus, the present study presents an uncommon manifestation of SPG75, the first from the Pakistani population, and broadens the spectrum of MAG variants
Corrigendum to "Investigations into structure-property relationships of novel Ru(II) dyes with N,N'-Diethyl group in ancillary ligand for dye-sensitized solar cells" [Dyes Pigments 171(2019) 107754-107762](S0143720819314639)(10.1016/j.dyepig.2019.107754)
No full textThe authors regret the typos in the author names and affiliations. The authors would like to apologize for any inconvenience caused. Correction: The correct author names and affiliations should read as follows: Saba Ashrafa,b,d, Rui Sud, Javeed Akhtarc, Humaira M. Siddiqib, Ahmed Shujae, Khalid Al-Saadf, Siham Y. Al-Qaradawif, Ahmed El-Shafeid*[email protected] aSulaiman Bin Abdullah Aba Al-Khail - Centre for Interdisciplinary Research in Basic Science (SA-CIRBS), International Islamic University, Sector H-10, Islamabad, Pakistan bDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan cMaterials Laboratory, Department of Chemistry, Mirpur University of Science and Technology (MUST), Mirpur, 10250, AK, Pakistan dPolymer and Color Chemistry Program & Fiber and Polymer Science Program, North Carolina State University, Raleigh, NC, 27606, USA eCentre for Advanced Electronics and Photovoltaic Engineering (CAEPE), International Islamic University, Sector H-10, Islamabad, Pakistan fDepartment of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, P.O. Box 2713, Doha, QatarScopu
Tinjauan Kriminologis Terhadap Peredaran Kosmetik Ilegal Yang Mengandung Bahan Berbahaya Di Kota Pekanbaru
No full textCrime prevention efforts are a series of efforts or activities carried out by BPOM in the context of tackling crime, including the distribution of illegal cosmetics. The distribution of illegal cosmetics in the background as the author describes is: These cosmetics do not use ingredients that meet the standards and quality requirements and other stipulated requirements, are not produced using good cosmetic manufacturing methods, are not registered with and obtain distribution permits from BPOM. The problems in this research are as follows: What are the factors that cause the distribution of illegal cosmetic products containing hazardous substances at the BPOM in Pekanbaru City? What are the efforts to prevent the Drug and Food Control Agency (BPOM) from tackling the distribution of illegal cosmetics in Pekanbaru City? The research method used by the author is observational with the census method, where the author goes directly to the field to find data that will be used as material for writing scientific papers, the data is taken through direct interviews. Furthermore, the data obtained from field studies and literature were collected, then processed and presented by comparing the field data with the opinions of experts or with the laws and regulations that were used as the basis for this research. The findings from the research results show that one of the factors causing the widespread distribution of illegal cosmetics in Pekanbaru City is the low price and easy access for consumers to get illegal cosmetics on the market. As well as the prevention efforts carried out by BPOM in tackling the distribution of illegal cosmetics in Pekanbaru City is by supervising and taking action against illegal cosmetics circulating on the market and imposing administrative sanctions on business actors who are proven to have violated the applicable laws and regulations
The Benzimidazole Derivatives, B1 (N-[(1H-Benzimidazol-2-yl)Methyl]-4-Methoxyaniline) and B8 (N-{4-[(1H-Benzimidazol-2-yl)Methoxy]Phenyl}Acetamide) Attenuate Morphine-Induced Paradoxical Pain in Mice
No full textDespite being routinely used for pain management, opioid use is limited due to adverse effects such as development of tolerance and paradoxical pain, including thermal hyperalgesia and mechanical allodynia. Evidence indicates that continued morphine administration causes increased expression of proinflammatory mediators such as tumor necrosis factor-alpha (TNF-α). The objectives of the present study were to determine the effects of B1 (N-[(1H-benzimidazol-2-yl)methyl]-4-methoxyaniline) and B8 (N-{4-[(1H-benzimidazol-2-yl)methoxy]phenyl}acetamide), benzimidazole derivatives, on thermal nociception and mechanical allodynia during repeated morphine (intraperitoneal; 5 mg/kg twice daily for 6 days)-induced paradoxical pain and TNF-α expression in the spinal cord in mice. Our data indicate that administration of benzimidazole derivatives attenuated morphine-induced thermal hyperalgesia and mechanical allodynia. Benzimidazole derivatives also reduced TNF-α expression in mice. Taken together, these results suggest that benzimidazole derivatives might be useful for the treatment of neuroinflammatory consequences of continued morphine administration and could be potential drug candidates for the management of opioid-induced paradoxical pain
ANALISIS STRATEGI PENGEMBANGAN USAHA THE BOUNZ BAKERY DENGAN MENGGUNAKAN MATRIKS SWOT DAN IE
No full textJika membutuhkan abstrak atau isi jurnal silahkan menghubungi author melalui email [email protected] atau [email protected]
Dipublikasikan tanggal: 20 Oktober 202
Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives
No full textAbstract Background Isoxazole is an important pharmacophore in medicinal chemistry with a wide range of pharmacological activities. The present study deals with the synthesis and evaluation of antinociceptive potential of nine novel 3-substituted-isoxazole-4-carboxamide derivatives. Synthesis In the first step, respective oxime was prepared and further treated with ethylacetoacetate and anhydrous zinc chloride followed by hydrolysis of ester to furnish 3-substituted isoxazole-4-carboxylic acid. The respective carboxylic acids were converted to acid chlorides and condensed with aromatic amines to get the target carboxamide derivatives (A1–A5 and B1–B5). These compounds were characterized by FTIR, 1HNMR, 13CNMR and elemental analysis data and screened for their analgesic activity using acetic acid-induced writhing assay and hot plat test in mice and compared with the standard centrally acting analgesic, tramadol. Results All the synthesized carboxamide derivatives showed low to moderate analgesic activity. Among the synthesized derivatives B2 having methoxy (OCH3) showed high analgesic activity as compared to tramadol both in acetic acid-induced writhing assay and hot plate assay at dose of 6 mg/kg. To examine the involvement of opioidergic mechanism in the mediation of analgesic effects of isoxazole derivatives animals were further treated with non-selective opioid analgesic, naloxone (0.5 mg/kg). The results showed that compounds A3 and B2 follow a non-opioid receptor pathway in the mediation of analgesic effects. Synthesized compounds A3 and B2 were docked against non-opioid receptors COX-1 (3N8X), COX-2 (1PXX) and human capsaicin receptor (HCR, 3J9J) to analyze their binding interactions. They showed binding energies in the range of − 7.5 to − 9.7 kcal/mol. Conclusions The results indicated that isoxazole carboxamide derivatives possess moderate analgesic potential especially compounds A3 and B2 can be considered as lead molecules and explored further for pain management with fewer side effects
Permasalahan Konsepsi Harta Bersama Dalam Kepemilikan Saham Perseroan Terbatas (Studi Kasus Putusan Nomor 80/Pdt.G/2020/PN.Jkt.Utr)
No full textA limited liability company as a legal entity adheres to the principle of a separate legal entity which creates the concept of limited liability of its shareholders. The existence of these two concepts automatically separates the assets of the limited liability company from the personal assets of its shareholders. Even though the shareholders are part owners of the limited liability company, the shareholders cannot claim the assets of the limited liability company. Shares acquired while in marital status can become joint property. However, the Indonesian Marriage Law does not provide special arrangements or mechanisms regarding the distribution of joint assets, so the Judge is given the mandate to decide on this matter. The research method that the author uses in writing this thesis is a normative legal research method that is juridical-normative in nature. Based on the author\u27s analysis, there are still misunderstandings, both among the Panel of Judges and the general public, regarding the conception of legal entity assets as being related to joint assets in marriage. So, the author suggests making further arrangements regarding joint assets, increasing socialization regarding marriage agreements, and writing in more detail regarding the list of joint assets in lawsuits
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