102,072 research outputs found
Mutlu S_BLM_Tcell_Revised AJP_Final
No full text<p>Supplemental material for the paper called " </p>
<p><span>Adoptive transfer of T cells as a potential therapeutic approach in the bleomycin injured mouse lung</span>" submitted to AJP lung</p>
Assessment of mitogen-activated protein kinases as therapeutic targets for the treatment of babesiosis and theileriosis
No full textThe Piroplasmida order comprises parasitic protozoa including the Theileria and Babesia species that are transmitted by vector ticks and can cause severe diseases in domestic and wild animals. Because of limited therapies and available drug resistance, the discovery of new, effective, and safer drugs for veterinary use is important. Mitogen-activated protein kinases (MAPK) are a group of serine-threonine protein kinases found in diverse species, including animals and protozoa that conduct vital cellular functions. Therefore, they have been at the centre of drug design studies for many years. Computer-aided structure-based drug design is a fast and effective way in drug discovery efforts to identify candidate compounds. In this study, we conducted comparative sequence analysis of MAPK proteins from the Theileria (T. annulata, T. parva., T. orientalis, and T. equi) and Babesia species (B. bigemina, B. microti, and B. bovis). Three-dimensional protein structures from relevant species (T. annulata and B. bovis) were modelled and compounds were screened for interaction. Results showed that the inhibitors designed for human use could also be potent against Prioplasmida MAPKs. Furthermore, the structural differences between Prioplasmida and mammalian MAPKs could be a way for researchers to better instigate selective drug design
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Identification of potential inhibitors of Trichomonas vaginalis iron-containing superoxide dismutase by computer-aided drug design approach
No full textTrichomonas vaginalis is a human protozoan parasite that causes trichomoniasis, a common sexually transmitted disease. Metronidazole is a commonly used drug for the treatment of T. vaginalis infections. However, it was reported that the parasite has developed resistance to this drug. Therefore, a necessity of discovering new drugs that have different modes of action against T. vaginalis has emerged. In this computational study, T. vaginalis iron-containing superoxide dismutase (TvSOD) was selected as target protein because of its vital role in converting superoxide to oxygen and hydrogen peroxide and protecting the parasite against toxic reactive oxygen species (ROS). TvSOD was modeled using two different protein modeling programs, MODELLER and SWISS-MODEL, and then, small drug-like chemicals were screened for interaction with three different druggable pockets of the enzyme. The best interacting chemicals were then evaluated through molecular dynamics simulations (MDSs) for ligand stability. As a result, ligand-129817054 (7-(6-amino-1,2,3,4,5-pentahydroxyhexyl)-4-methylchromen-2-one) was determined to be a viable drug candidate based on docking scores and MDS results. Additional in vitro inhibition studies are necessary for the evaluation and assessment of the compound of interest as an effective TvSOD inhibitor
FreeSolv_Isole_NNP
No full text<p>Esma Mutlu, Gebze Teknik Üniversitesi Kimya Doktora öğrencisi ve TÜBİTAK 1001 projesinde proje asistanı olup hesaplamalı kimya, yapay zekâ tabanlı nöral ağ potansiyelleri ve moleküler modelleme üzerine çalışmaktadır.</p>
Mitral kapakta prolapsa baǧli yalanci Kitle görünümü [Mitral valve prolapse with mass-like appearance]
No full text[No abstract available
Age, growth, and gonadosomatic index (gsi) of mediterranean horse mackerel (trachurus mediterraneus steindachner, 1868) in the eastern black sea
No full textWOS: 000265870500005The aim of this study was to calculate the basic population parameters of Trachurus mediterraneus off the coast of the Eastern Black Sea. Average total length was estimated as 13.52 +/- 1.884 cm for the entire population, 13.08 +/- 1.594 cm for males, and 13.62 +/- 1.804 for females. Average weight was 20.27 +/- 8.819 g for the entire population, 18.65 +/- 7.626 g for males, and 2131 +/- 9.184 g for females. Age of the fish ranged between 0 and 5 years. Length-weight, age-length, and age-weight relationships were estimated for the population, where W = 0.0089 x L-2.9552: L-t = 26.09 (1 - e(-0.125(t + 4.002))); and W-t = 136.56 (1 - e(-0.125(t + 4.002))) Total mortality rates were Z = 3.73 year(-1) and M = 0.29 year for natural deaths. and F = 3.44 year(-1) for fishing mortality.Scientific Research Fund of Karadeniz Technical UniversityThis study was financially supported by the Scientific Research Fund of Karadeniz Technical University. We would also like to thank Prof. Dr. Ertug Duzgunes for his invaluable comments about this study
Experimentation and analysis of powder injection molded Ti10Nb10Zr alloy: a promising candidate for electrochemical and biomedical application
No full textThis paper describes the microstructural, mechanical and corrosion properties of injection molded Ti10Nb10Zr alloys. T10Nb10Zr powder was injection molded with wax-based binder. The critical powder loading for injection molding was 55 vol% for feedstock. Binder debinding was performed in solvent and thermal method. After debinding the samples were sintered at different temperatures and times in vacuum atmosphere (10-5 mbar) to obtain fully dense parts. Metallographic studies were conducted to determine the extent of densification and the corresponding microstructural changes. The electrochemical property and biocompatibility of the sintered samples were performed electrochemically, by selfbody -fluid immersion tests and cell culture experiments. The results show that Ti10Nb10Zr alloys could be sintered to a maximum 99% of theoretical density. Maximum ultimate tensile strength, elongation and hardness obtained were 748 MPa, 14.3 and 114 HRB respectively at 1500 degrees C for 3 h. Additionally, the sintered i10Nb10Zr alloys exhibited high mechanical and corrosion properties in a physiological environment. (C) 2019 The Author. Published by Elsevier B.V
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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