101,603 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Towards safe and effective CD38-CAR T cell therapy for myeloma
No full textImmunotherapy is a promising field within cancer therapy. The recent progresses resulted in 'Immunotherapy for the treatment of cancer' as break-through of the year in 2013. This was partly due to the great successes with Chimeric Antigen Receptor (CAR) T cell therapy. With CAR T cells, recognition takes place via a cleverly synthesized receptor made in the laboratory on the basis of an antibody, which has been made part of the T cell receptor via genetic manipulation. Clinical studies with CAR T cells have shown how strong this anti-tumor weapon is. In order to make CAR T cell therapy accessible to more patients, we focus on different targets, such as CD38 for multiple myeloma. In the past 30 years, the treatment of multiple myeloma has greatly improved, with improved survival rates. Very recent research has shown that antibodies against CD38 have proven clinical benefit. CD38 is a molecule that is present in large numbers (high expression) on multiple myeloma cells. In this thesis we study the possibility to target CARs against CD38 and we studied ways to improve the therapy and reduce toxicity. These important aspects of the development of CAR T cells have been studied and presented in this thesis: towards a safe and applicable CAR T cell treatment for multiple myeloma
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
T-control: T-cell therapy in the context of allogeneic stem cell transplantation
No full textHLA-matched allogeneic stem cell transplantation (alloSCT) is a potential curative therapy for patients with high-risk hematologic malignancies. The therapeutic effect of alloSCT is mediated by T cells derived from the stem cell donor that have the potential to recognize and eliminate malignant cells of patient origin, better known as the graft-versus-leukemia effect. Besides, donor-derived T cells are of importance for the protection against viruses early after alloSCT. On the other hand, T cells of donor origin can also initiate harmful graft-versus-host disease if healthy cells of the patient are recognized. Therefore, the major challenge in the field of alloSCT is to find a balance between graft-versus-leukemia effect and viral protection versus graft-versus-host disease with the aim to reduce complications early after alloSCT. In this thesis, the manipulation of donor-derived T cells at different stages during the process of HLA-matched alloSCT was investigated: from in vitro T-cell depletion of the graft before infusion into the patient until adoptive T-cell therapy early after alloSCT to support anti-viral immunity and graft-versus-leukemia effect. Financially supported by the European Union’s seventh Framework Program (FP/2007-2013).LUMC / Geneeskund
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
CD38(low) Natural Killer Cells Transiently Expressing CD16(F158V) m-RNA Potentiates the Therapeutic Activity of Daratumumab Against Multiple Myeloma with Minimal Effector NK Cell Fratricide
No full textPera arborea Mutis from Colombia collected by F. Toro, E. Álvarez, A. Camargo #280
No full textFile Name: TOLI-25241-ZAR-05-340.jpg
CÓDIGO FOTO: TOLI-25241-ZAR-05-340-
Fotografía: SI
Nº TOLI: TOLI-25241
PARCELA: ZAR-05
CÓDIGO: 340
Nº COLECTA: 280
NUEVOS COLECTORES: Alejandro Camargo, Felipe Toro & Esteban Alvarez
COLECTORES: F. Toro, E. Álvarez, A. Camargo
Nº MUESTRAS MONTADAS: 1
Homologación: Homologado
Nueva fecha del evento : 30/11/2018.
Fecha del evento: 27/04/2019.
Proyecto : Recursos Botánicos Disponibles en Línea (BRAVO) para la flora Colombiana
Hábitat: Bosque húmedo tropical (bh-T)
Comentario del evento: Bosque de tierra firme
Continente: SA
Pais: Colombia
Estado/Provincia: Amazonas
Municipio: Leticia
Localidad: Resguardo Indígena Ticuna-Huitoto Km 6-11.
Elevación minima en metros: 200
Elevación maxima en metros: 300
Latitud: -4.004
Longitud original: -69.896
datum geodésico: WGS 84
Latitud decimal: -4.004
Longitud decimal: -69.896
Identificado por: Federico Fabriani
Fecha de identificación: 23/01/2019.
Familia antigua: Euphorbiaceae
Especie antigua: Pera cf. arborea Mutis
Nombre cientifico: Pera arborea Mutis
Reino: Plantae
Filo: Magnoliophyta
Clase: Equisetopsida
Orden: Malpighiales
Familia nueva: Peraceae
Género nuevo: Pera
especie nueva: arborea
Autoría del nombre científico: Mutis
: Euphorbiaceae
genero herbario: Pera
especie herbario: arborea
Especie de herbario para TNRS: Pera arborea
Especie corregida herbario y desde TNRS: Pera arborea
Familia corregida desde TNRS: Euphorbiaceae
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