1,721,383 research outputs found
Elite athletes and COVID-19 lockdown: Future health concerns for an entire sector
Full text linkIn this editorial, we focused our attention on elite athletes during the COVID-19 lockdown. A high level of physical fitness is required by elite athletes irrespective of the specific type of sport. Generally speaking, elite athletes avoid long periods of rest during and at the end of the competitive season. Normally, elite athletes stop training or reduce training volume and intensity for a period that ranges from two weeks to a maximum of four weeks
Expression and localization of aquaporin-1 in temporomandibular joint disc with internal derangement
No full textJ Oral Pathol Med. 2012 May 3. doi: 10.1111/j.1600-0714.2012.01156.x. [Epub ahead of print]
Expression and localization of aquaporin-1 in temporomandibular joint disc with internal derangement.
Loreto C, Galanti C, Almeida LE, Leonardi R, Pannone G, Musumeci G, Carnazza ML, Caltabiano R.
Source
Department of Bio-Medical Sciences, University of Catania, Catania, Italy Department of Dentistry, Faculty of Dentistry, University of Catania, Policlinico Universitario, Catania, Italy Center for Health and Biological Sciences, Pontifical Catholic, University of Panarà, Curitibe, Brazil Department of Surgical Sciences, Institute of Pathology and Cytopathology, University of Foggia, Foggia, Italy Department of Anatomy, Diagnostic Pathology, Forensic Medicine, Hygiene and Public Health, University of Catania, Catania, Italy.
Abstract
Internal derangement is the most J Oral Pathol Med (2012) Background: frequent arthropathy affecting the temporomandibular joint, where its commonest form is anterior disc displacement with or without reduction. Despite the frequency of the disorder, the biochemical features of displaced discs are still We investigated the expression pattern and localization of unclear. Methods: aquaporin-1, an important channel protein involved in plasma membrane water permeability, in patients with anterior disc displacement (both with and without reduction), with a view to assessing the characteristics of local tissue responses to the microenvironmental changes induced by abnormal mechanical loading of the displaced disc. Protein expression was studied by immunohistochemistry in different areas of discs from 18 patients with anterior disc displacement with or without reduction and in four normal controls. A greater proportion of cells immunopositive for aquaporin-1 were Results: detected in diseased than in normal discs. Whereas protein expression was substantially similar in the different areas of normal discs, a significantly larger number of immunopositive cells were detected in the posterior band of displaced discs without reduction and in the anterior and intermediate bands of These findings suggest that aquaporin-1 is those with reduction. Conclusions: expressed and upregulated in temporomandibular joint with anterior disc displacement (both with and without reduction)
Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes
No full textAging is a natural process by which every
single living organism approaches its twilight of
existence in a natural way. However, aging is also linked
to the pathogenesis of a number of complex diseases.
This is the case for osteoarthritis (OA), where age is
considered to be a major risk factor of this important and
increasingly common joint disorder. Half of the world's
population, aged 65 and older, suffers from OA.
Although the relationship between the development of
OA and aging has not yet been completely understood, it
is thought that age-related changes correlate with other
risk factors. The most prominent hypothesis linking
aging and OA is that chondrocytes undergo premature
aging due to several factors, such as excessive
mechanical load or oxidative stress, which induce the so
called “stress-induced senescent state”, which is
ultimately responsible for the onset of OA. This review
focuses on molecular markers and mechanisms
implicated in chondrocyte aging and the pathogenesis of
OA. We discuss the most important age-related
morphological and biological changes that affect
articular cartilage and chondrocytes. We also identify the
main senescence markers that may be used to recognize
molecular alterations in the extracellular matrix of
cartilage as related to senescence. Since the aging
process is strongly associated with the onset of
osteoarthritis, we believe that strategies aimed at
preventing chondrocyte senescence, as well as the
identification of new increasingly sensitive senescent
markers, could have a positive impact on the
development of new therapies for this severe disease
Cryopreserved Penile Tunica Albuginea for Allotransplantation: A Morphological and Ultrastructural Investigation
Full text linkIntroduction. Peyronie's disease, a connective tissue disorder of penile tunica albuginea (TA) associated with penile deformity, curvature, pain, and erectile dysfunction, is best managed surgically, but suitable graft biomaterials are not available. Aim. To establish whether cryopreservation affects human TA in view of its use in allotransplants. Methods. The effects on TA samples of the two most widely used tissue cryopreservation methods were investigated using an ad hoc panel of histochemical, immunohistochemical, and ultrastructural tests. Apoptotic cells were evaluated using the terminal deoxynucleotidyl transferase method of end labeling (TUNEL) assay. Main Outcome Measures. Assessment of tissue integrity and arrangement of collagen and elastic fibers in thawed TA. Results. Both cryofixation methods provided TA tissue suitable for use as graft material. Significant ultrastructural changes, namely, a greater diameter of collagen fibrils, were detected in sections preserved in liquid nitrogen; nonetheless, such increase never exceeded the normal range. The comprehensive panel of assays used proved suitable to characterize the thawed tissue. Conclusion. Human TA is suitable for cryopreservation; freezing at -80°C provides better results than preservation in liquid nitrogen. Loreto C, Orlandi A, Ferlosio A, Djinovic R, Basic D, Bettocchi C, Rutigliano M, Barbagli G, Vespasiani G, Caltabiano R, Musumeci G, and Sansalone S. Cryopreserved penile tunica albuginea for allotransplantation: A morphological and ultrastructural investigation. J Sex Med **;**:**-**
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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