296 research outputs found
Virtuoso : Hrvatski skladatelji (studenti Muzičke akademije Sveučilišta u Zagrebu, 27. 5. 2021.)
No full textKoncert iz ciklusa Virtuoso održan na Muzičkoj akademiji u Koncertnoj dvorani "Blagoje Bersa" 27. 5. 2021. Izvođači: Mihael Hrgar (tuba), Martina Barišić (sopran), Petar Krokar (klavir), Božidar Vlašić (klavir), Matej Fridl (rog), Marko Gugić (rog), Lovre Laskač (rog), Bruno Laktaš (rog), Stefani Pijetlović (sopran), Brigita Kitner (klavir), Ansambl flauta Muzičke akademije Sveučilišta u Zagrebu (Iva Primorac (flauta piccolo), Ana Tutić (flauta), Nikolina Hapač (flauta), Marija Sušić (flauta), Maja Mustapić (flauta), Lucija Družinec (alt flauta), Ana Kovačev (alt flauta), Sara Lončar (alt flauta), Erin Keleuva (bas flauta), Doris Vincek (bas flauta)). Program: 1. M. Brekalo: Game of Kobalos (izvođač: Mihael Hrgar); 2. M. Cipra: Dvije djevojačke pjesme (I. Udaralo u tamburu đače - II. Oj volaru medena ti usta) (izvođači: Martina Barišić, Petar Krokar); 3. B. Papandopulo: Kaleidoskop 74, suita za glasovir (I. - V. - VI. Vivo) (izvođač: Božidar Vlašić); 4. T. Uhlik: Sjećanje na prijatelja, studija za četiri roga (izvođači: Matej Fridl, Marko Gugić, Lovre Laskač, Bruno Laktaš); 5. J. Hatze: „Arija rastanka“, arija Mare iz opere „Adel i Mara“ (izvođači: Stefani Pijetlović, Brigita Kitner); 6. I. Tijardović: „Daleko me biser mora“, arija Suzette iz operete „Mala Floramye“ (izvođači: Stefani Pijetlović, Brigita Kitner); 7. T. Uhlik: Karusel (izvođači: Ansambl flauta Muzičke akademije Sveučilišta u Zagrebu)
Odhad momentů při intervalovém cenzorování typu I
No full textTitle: Moments Estimation under Type I Interval Censoring Author: Matej Ďurčík Department: Faculty of Probability and Mathematical Statistics Supervisor: RNDr. Arnošt Komárek Ph.D. Abstract: In this thesis we apply the uniform deconvolution model to the interval censoring problem. We restrict ourselves only on interval censoring case 1. We show how to apply uniform deconvolution model in estimating the probability distribution characteristics in the interval censoring case 1. Moreover we derive limit distributions of the estimators of mean and variance. Then we compare these estimators to the asymptotically efficient estimators based on the nonparametric maximum likelihood estimation by simulation studies under some certain distributions of the random variables.
Antinociceptive effect of botulinum toxin type A in an animal model of formalin-induced pain
No full textBotulinum toksin tipa A (BT-A) neurotoksin je kojeg sintetizira bakterija Clostridium botulinum. Njegov specifični
mehanizam djelovanja, koji uključuje proteolitičko kidanje SNAP-25 proteina odgovornog za egzocitozu
neurotransmitera, prepoznat je kao moguće farmakološko rješenje nekih poremećaja autonomnog živčanog sustava,
stanja povezanih s hiperkontraktilnošću mišića i određenih vrsta boli. Antinociceptivni učinak BT-A dugo se vremena
smatrao posljedicom inhibicije perifernog lučenja neurotransmitera, no danas se vjeruje da su u pozadini složeni i još
uvijek nerazjašnjeni mehanizmi unutar središnjeg živčanog sustava (SŽS). Cilj ovog istraživanja bio je ispitati
mogućnost transcitoze kao jednog od mehanizama koji doprinosi kompleksnom središnjem djelovanju BT-A na bol.
BT-A (7 i.j./kg) je unilateralno primijenjen u područje brka Wistar štakora jedan dan prije primjene neutralizirajućeg
antitoksina za BT-A (anti-BT-A) (5 i.j./10 μL) u veliku moždanu komoru. Nakon sedam dana od primjene BT-A,
uzrokovana je bol primjenom formalina (2,5 %) te se kroz period od 45 minuta mjerila učestalost ponašanja povezanih
s boli. Periferno primijenjen BT-A smanjio je bol unutar druge faze formalinskog testa koja odgovara ranoj upalnoj
boli. Anti-BT-A poništio je antinociceptivno djelovanje BT-A, što sugerira središnje učinke BT-A na bol posredovane
transcitozom. Budući da primjena kolhicina, blokatora aksonalnog transporta, u trigeminalni ganglij s kontralateralne
strane nije utjecala na antinociceptivni učinak BT-A, isključena je periferna difuzija toksina i sistemsko širenje na
kontralateralnu stranu. Dodatno, primjenom BT-A sa suprotne strane od mjesta indukcije boli pokazan je
antinociceptivni učinak u upalnoj fazi formalinskog testa, što ukazuje da je kontralateralni učinak BT-A na bol
neovisan o mjestu ozljede i djelovanju toksina na strani primjene. Zaključno, rezultati prikazani u ovom diplomskom
radu doprinose razjašnjenju kompleksnog središnjeg djelovanja BT-A na bol. Po prvi puta se predlaže transcitoza u
senzornom sustavu kao važan čimbenik u antinociceptivnom učinku BT-A, što zahtijeva daljnja detaljna istraživanja.Botulinum toxin type A (BoNT-A) is a neurotoxin synthesised by the bacterium Clostridium botulinum. Its specific
mechanism of action, which involves proteolytic cleavage of SNAP-25, a protein responsible for exocytosis of various
neurotransmitters, was recognized as a possible pharmacological solution for some autonomic disorders, conditions
accompanied by muscle hypercontractility and certain types of pain. Antinociceptive effect of BoNT-A was long
considered to be the consequence of solely peripheral inhibition of neurotransmitter exocytosis, but nowadays it is
believed that more complex and still unresolved mechanisms are at play. The aim of this study was to investigate the
possibility of transcytosis as a mechanism underlying the complex central action of BoNT-A on pain. BoNT-A (7
IU/kg) was unilaterally administered in the facial vibrissae of Wistar rats a day before the injection of antibody against
BoNT-A (5 IU/10μL) inside the cisterna magna. After seven days, pain was caused by formalin application (2.5%) and
the frequency of pain-associated behaviours was measured at 5-minute intervals over a period of 45 minutes.
Peripherally applied BoNT-A reduced pain during the second phase of formalin test, corresponding to early
inflammatory pain. Anti-BoNT-A prevented antinociceptive effect of BoNT-A, proposing central effects, mediated by
transcytosis. Since the application of colchicine, an axonal transport blocker, in the contralateral trigeminal ganglion
did not affect the antinociceptive effect of BoNT-A, possibility of peripheral diffusion of toxin and systemic spread to
the contralateral side was excluded. Additionally, when BT-A was applied on the opposite side of the pain induction
site, an antinociceptive effect was observed during the inflammatory phase of the formalin test, indicating that the
contralateral effect of BT-A on pain is independent of the site of injury and the action of toxin on the site of
application. In conclusion, the results presented in this master’s thesis contribute to the elucidation of the complex
central action of BoNT-A on pain. For the first time, transcytosis in the sensory system is proposed as an important
factor in the antinociceptive effect of BT-A, which requires further detailed investigation
DEVELOPMENT OF CONTENT ON DEMAND SYSTEM ON XBMC PLATFORM
No full textV diplomski nalogi predstavljamo razvoj sistema vsebin na zahtevo na XBMC platformi. V nalogi predstavimo infrastrukturo sistema IPTV, pripadajoče storitve ter module sistema. Za sistem UMB-SmartTV smo razvili tudi nov XBMC vtičnik za pregled lastnih vsebin. Vtičnik omogoča pregled in predvajanje različnih vsebin na sistemu UMB SmartTV, ki jih lahko uporabnik dodaja v bazo sistema. Podatke o vsebinah je mogoče pregledovati glede na želene kategorije: žanr, leto nastanka, režiser, igralci, avtor itd. Poudarek pri razvoju sistema smo namenili čim hitrejšemu iskanju vsebin, kar smo dosegli tudi z razvrščanjem vsebin v kategorije.The purpose of the diploma thesis is to introduce the development of a Content-on-Demand system on the XBMC platform. The thesis deals with the architecture of the IPTV system, the services that are delivered through this system and its modules. Furthermore we have developed a new XBMC plugin for the content review for the UMB-SmartTV system. The plugin allows the user to view and play various contents that can be added to the system’s database on the UMB-SmartTV system. The user is able to review the information about the content by selecting between different categories like genre, director, actors, author etc. The main goal was to develop a system that provides fast search for specific content and the classification of the content into categories that can help us to access it
The predictive value of initial spinal MRI findings for post-therapeutic clinical outcome of vertebral osteomyelitis
No full textCilj istraživanja: Analizirati početne kliničke, laboratorijske i nalaze inicijalnog pregleda kralježnice magnetskom rezonancijom (MR) u bolesnika s vertebralnim osteomijelitisom, te odrediti njihovu povezanost s konačnim ishodom bolesti. ----- Ispitanici i metode: Retrospektivno istraživanje 110 bolesnika s potvrđenim piogenim vertebralnim osteomijelitisom koji su bili hospitalizirani u razdoblju od 5 godina i to od 2006. do 2010. godine. Svim ispitanicima su učinjene kliničke i laboratorijske pretrage te inicijalno i MR pregled kralježnice prema istom protokolu. Ispitanici su podijeljeni u dvije skupine ovisno o nalazima MR pregleda i to: ispitanici s ranim i ispitanici s uznapredovalim promjenama. Kao ishodi bolesti razmatrani su: potpuni klinički oporavak, rezidualni neurološki deficit ili bol i smrt, te je analiziran njihov odnos s kliničkim i slikovnim nalazima. ----- Rezultati: Nije bilo statistički značajne razlike u početnim kliničkim osobitostima ispitanika, broju zahvaćenih kralježaka i anatomskom položaju, između dvije skupine ispitanika. Viši stupanj komorbiditeta i produženo liječenje antibioticima bili su povezani s uznapredovalim promjenama na MR pregledu kralježnice (p=0.006, odnosno p=0.004). Ispitanici koji su pokazivali uznapredovale promjene na MR pregledu kralježnice češće su bili kirurški liječeni (p=0.007). Nije pronađena statistički značajna razlika u ishodu bolesti između ispitanika s ranim i ispitanika s uznapredovalim MR promjenama kralježnice (p=0.563). ----- Zaključak: Premda su ispitanici s uznapredovalim promjenama na MR pregledu kralježnice češće trebali produženu antibiotsku terapiju i kirurško liječenje, nalaz inicijalnog MR pregleda kralježnice u bolesnika s piogenim vertebralnim osteomijelitisom nije pokazao prognostičku vrijednost za ishod bolesti. Uznapredovale promjene na MR pregledu kralježnice češće se vide u ispitanika s višim stupnjem komorbiditeta, što je vjerojatno uvjetovano oslabljenim imunološkim odgovorom bilo zbog primjerice šećerne bolesti ili kroničnog bubrežnog zatajenja, ili zbog djelomične promjene imunološkog odgovora lijekovima u bolesnika s upalnim reumatskim bolestima, što također umanjuje i osjet boli.Aim: To analyze the initial clinical, laboratory and magnetic resonance imaging (MRI) findings in patients with vertebral osteomyelitis and to determine their correlation with the disease outcome. ----- Patients and methods: A retrospective study of 110 patients with confirmed pygenic vertebral osteomyelitis treated in a 5-year period, between 2006 and 2010. Patients included in the study initially had clinical and biological examinations and MRI of spine according to the same protocol. MRI findings were divided in moderate and advanced changes. Complete clinical recovery, residual neurological deficits or pain and death were observed as the disease outcome and put in correlation with clinical and imaging findings. ----- Results: There was no significant difference in clinical presentation at admission, number of affected vertebral bodies nor anatomic location between a group of patients with moderate and patients with advanced MRI changes. High Charlson comorbity index (CCI) score and longer treatment with antibiotics were associated with advanced MRI changes (p=0.006 and p=0.004, respectively). Patients with advanced MRI changes more frequently underwent surgical intervention than patients with moderate MRI changes of vertebral osteomyelitis (p=0.007). There was no difference between patients with moderate and patients with advanced MRI changes regarding the disease outcome (p=0.563). ----- Conclusion: Although the patients with advanced MRI changes are more likely to need prolonged antibiotic therapy and surgical intervention, the findings of initially performed MRI in patients with pyogenic vertebral osteomyelitis have no prognostic value regarding the disease outcome. The advanced MRI changes in patients with vertebral osteomyelitis are more often observed in patients with high CCI score, probably due to impaired immune response caused by diabetes or chronic renal failure or because of partial modulation of the immune response with medications in patients with inflammatory rheumatic diseases
The predictive value of initial spinal MRI findings for post-therapeutic clinical outcome of vertebral osteomyelitis
No full textCilj istraživanja: Analizirati početne kliničke, laboratorijske i nalaze inicijalnog pregleda kralježnice magnetskom rezonancijom (MR) u bolesnika s vertebralnim osteomijelitisom, te odrediti njihovu povezanost s konačnim ishodom bolesti. ----- Ispitanici i metode: Retrospektivno istraživanje 110 bolesnika s potvrđenim piogenim vertebralnim osteomijelitisom koji su bili hospitalizirani u razdoblju od 5 godina i to od 2006. do 2010. godine. Svim ispitanicima su učinjene kliničke i laboratorijske pretrage te inicijalno i MR pregled kralježnice prema istom protokolu. Ispitanici su podijeljeni u dvije skupine ovisno o nalazima MR pregleda i to: ispitanici s ranim i ispitanici s uznapredovalim promjenama. Kao ishodi bolesti razmatrani su: potpuni klinički oporavak, rezidualni neurološki deficit ili bol i smrt, te je analiziran njihov odnos s kliničkim i slikovnim nalazima. ----- Rezultati: Nije bilo statistički značajne razlike u početnim kliničkim osobitostima ispitanika, broju zahvaćenih kralježaka i anatomskom položaju, između dvije skupine ispitanika. Viši stupanj komorbiditeta i produženo liječenje antibioticima bili su povezani s uznapredovalim promjenama na MR pregledu kralježnice (p=0.006, odnosno p=0.004). Ispitanici koji su pokazivali uznapredovale promjene na MR pregledu kralježnice češće su bili kirurški liječeni (p=0.007). Nije pronađena statistički značajna razlika u ishodu bolesti između ispitanika s ranim i ispitanika s uznapredovalim MR promjenama kralježnice (p=0.563). ----- Zaključak: Premda su ispitanici s uznapredovalim promjenama na MR pregledu kralježnice češće trebali produženu antibiotsku terapiju i kirurško liječenje, nalaz inicijalnog MR pregleda kralježnice u bolesnika s piogenim vertebralnim osteomijelitisom nije pokazao prognostičku vrijednost za ishod bolesti. Uznapredovale promjene na MR pregledu kralježnice češće se vide u ispitanika s višim stupnjem komorbiditeta, što je vjerojatno uvjetovano oslabljenim imunološkim odgovorom bilo zbog primjerice šećerne bolesti ili kroničnog bubrežnog zatajenja, ili zbog djelomične promjene imunološkog odgovora lijekovima u bolesnika s upalnim reumatskim bolestima, što također umanjuje i osjet boli.Aim: To analyze the initial clinical, laboratory and magnetic resonance imaging (MRI) findings in patients with vertebral osteomyelitis and to determine their correlation with the disease outcome. ----- Patients and methods: A retrospective study of 110 patients with confirmed pygenic vertebral osteomyelitis treated in a 5-year period, between 2006 and 2010. Patients included in the study initially had clinical and biological examinations and MRI of spine according to the same protocol. MRI findings were divided in moderate and advanced changes. Complete clinical recovery, residual neurological deficits or pain and death were observed as the disease outcome and put in correlation with clinical and imaging findings. ----- Results: There was no significant difference in clinical presentation at admission, number of affected vertebral bodies nor anatomic location between a group of patients with moderate and patients with advanced MRI changes. High Charlson comorbity index (CCI) score and longer treatment with antibiotics were associated with advanced MRI changes (p=0.006 and p=0.004, respectively). Patients with advanced MRI changes more frequently underwent surgical intervention than patients with moderate MRI changes of vertebral osteomyelitis (p=0.007). There was no difference between patients with moderate and patients with advanced MRI changes regarding the disease outcome (p=0.563). ----- Conclusion: Although the patients with advanced MRI changes are more likely to need prolonged antibiotic therapy and surgical intervention, the findings of initially performed MRI in patients with pyogenic vertebral osteomyelitis have no prognostic value regarding the disease outcome. The advanced MRI changes in patients with vertebral osteomyelitis are more often observed in patients with high CCI score, probably due to impaired immune response caused by diabetes or chronic renal failure or because of partial modulation of the immune response with medications in patients with inflammatory rheumatic diseases
Antinociceptive effect of botulinum toxin type A in an animal model of formalin-induced pain
No full textBotulinum toksin tipa A (BT-A) neurotoksin je kojeg sintetizira bakterija Clostridium botulinum. Njegov specifični
mehanizam djelovanja, koji uključuje proteolitičko kidanje SNAP-25 proteina odgovornog za egzocitozu
neurotransmitera, prepoznat je kao moguće farmakološko rješenje nekih poremećaja autonomnog živčanog sustava,
stanja povezanih s hiperkontraktilnošću mišića i određenih vrsta boli. Antinociceptivni učinak BT-A dugo se vremena
smatrao posljedicom inhibicije perifernog lučenja neurotransmitera, no danas se vjeruje da su u pozadini složeni i još
uvijek nerazjašnjeni mehanizmi unutar središnjeg živčanog sustava (SŽS). Cilj ovog istraživanja bio je ispitati
mogućnost transcitoze kao jednog od mehanizama koji doprinosi kompleksnom središnjem djelovanju BT-A na bol.
BT-A (7 i.j./kg) je unilateralno primijenjen u područje brka Wistar štakora jedan dan prije primjene neutralizirajućeg
antitoksina za BT-A (anti-BT-A) (5 i.j./10 μL) u veliku moždanu komoru. Nakon sedam dana od primjene BT-A,
uzrokovana je bol primjenom formalina (2,5 %) te se kroz period od 45 minuta mjerila učestalost ponašanja povezanih
s boli. Periferno primijenjen BT-A smanjio je bol unutar druge faze formalinskog testa koja odgovara ranoj upalnoj
boli. Anti-BT-A poništio je antinociceptivno djelovanje BT-A, što sugerira središnje učinke BT-A na bol posredovane
transcitozom. Budući da primjena kolhicina, blokatora aksonalnog transporta, u trigeminalni ganglij s kontralateralne
strane nije utjecala na antinociceptivni učinak BT-A, isključena je periferna difuzija toksina i sistemsko širenje na
kontralateralnu stranu. Dodatno, primjenom BT-A sa suprotne strane od mjesta indukcije boli pokazan je
antinociceptivni učinak u upalnoj fazi formalinskog testa, što ukazuje da je kontralateralni učinak BT-A na bol
neovisan o mjestu ozljede i djelovanju toksina na strani primjene. Zaključno, rezultati prikazani u ovom diplomskom
radu doprinose razjašnjenju kompleksnog središnjeg djelovanja BT-A na bol. Po prvi puta se predlaže transcitoza u
senzornom sustavu kao važan čimbenik u antinociceptivnom učinku BT-A, što zahtijeva daljnja detaljna istraživanja.Botulinum toxin type A (BoNT-A) is a neurotoxin synthesised by the bacterium Clostridium botulinum. Its specific
mechanism of action, which involves proteolytic cleavage of SNAP-25, a protein responsible for exocytosis of various
neurotransmitters, was recognized as a possible pharmacological solution for some autonomic disorders, conditions
accompanied by muscle hypercontractility and certain types of pain. Antinociceptive effect of BoNT-A was long
considered to be the consequence of solely peripheral inhibition of neurotransmitter exocytosis, but nowadays it is
believed that more complex and still unresolved mechanisms are at play. The aim of this study was to investigate the
possibility of transcytosis as a mechanism underlying the complex central action of BoNT-A on pain. BoNT-A (7
IU/kg) was unilaterally administered in the facial vibrissae of Wistar rats a day before the injection of antibody against
BoNT-A (5 IU/10μL) inside the cisterna magna. After seven days, pain was caused by formalin application (2.5%) and
the frequency of pain-associated behaviours was measured at 5-minute intervals over a period of 45 minutes.
Peripherally applied BoNT-A reduced pain during the second phase of formalin test, corresponding to early
inflammatory pain. Anti-BoNT-A prevented antinociceptive effect of BoNT-A, proposing central effects, mediated by
transcytosis. Since the application of colchicine, an axonal transport blocker, in the contralateral trigeminal ganglion
did not affect the antinociceptive effect of BoNT-A, possibility of peripheral diffusion of toxin and systemic spread to
the contralateral side was excluded. Additionally, when BT-A was applied on the opposite side of the pain induction
site, an antinociceptive effect was observed during the inflammatory phase of the formalin test, indicating that the
contralateral effect of BT-A on pain is independent of the site of injury and the action of toxin on the site of
application. In conclusion, the results presented in this master’s thesis contribute to the elucidation of the complex
central action of BoNT-A on pain. For the first time, transcytosis in the sensory system is proposed as an important
factor in the antinociceptive effect of BT-A, which requires further detailed investigation
Antinociceptive effect of botulinum toxin type A in an animal model of formalin-induced pain
No full textBotulinum toksin tipa A (BT-A) neurotoksin je kojeg sintetizira bakterija Clostridium botulinum. Njegov specifični
mehanizam djelovanja, koji uključuje proteolitičko kidanje SNAP-25 proteina odgovornog za egzocitozu
neurotransmitera, prepoznat je kao moguće farmakološko rješenje nekih poremećaja autonomnog živčanog sustava,
stanja povezanih s hiperkontraktilnošću mišića i određenih vrsta boli. Antinociceptivni učinak BT-A dugo se vremena
smatrao posljedicom inhibicije perifernog lučenja neurotransmitera, no danas se vjeruje da su u pozadini složeni i još
uvijek nerazjašnjeni mehanizmi unutar središnjeg živčanog sustava (SŽS). Cilj ovog istraživanja bio je ispitati
mogućnost transcitoze kao jednog od mehanizama koji doprinosi kompleksnom središnjem djelovanju BT-A na bol.
BT-A (7 i.j./kg) je unilateralno primijenjen u područje brka Wistar štakora jedan dan prije primjene neutralizirajućeg
antitoksina za BT-A (anti-BT-A) (5 i.j./10 μL) u veliku moždanu komoru. Nakon sedam dana od primjene BT-A,
uzrokovana je bol primjenom formalina (2,5 %) te se kroz period od 45 minuta mjerila učestalost ponašanja povezanih
s boli. Periferno primijenjen BT-A smanjio je bol unutar druge faze formalinskog testa koja odgovara ranoj upalnoj
boli. Anti-BT-A poništio je antinociceptivno djelovanje BT-A, što sugerira središnje učinke BT-A na bol posredovane
transcitozom. Budući da primjena kolhicina, blokatora aksonalnog transporta, u trigeminalni ganglij s kontralateralne
strane nije utjecala na antinociceptivni učinak BT-A, isključena je periferna difuzija toksina i sistemsko širenje na
kontralateralnu stranu. Dodatno, primjenom BT-A sa suprotne strane od mjesta indukcije boli pokazan je
antinociceptivni učinak u upalnoj fazi formalinskog testa, što ukazuje da je kontralateralni učinak BT-A na bol
neovisan o mjestu ozljede i djelovanju toksina na strani primjene. Zaključno, rezultati prikazani u ovom diplomskom
radu doprinose razjašnjenju kompleksnog središnjeg djelovanja BT-A na bol. Po prvi puta se predlaže transcitoza u
senzornom sustavu kao važan čimbenik u antinociceptivnom učinku BT-A, što zahtijeva daljnja detaljna istraživanja.Botulinum toxin type A (BoNT-A) is a neurotoxin synthesised by the bacterium Clostridium botulinum. Its specific
mechanism of action, which involves proteolytic cleavage of SNAP-25, a protein responsible for exocytosis of various
neurotransmitters, was recognized as a possible pharmacological solution for some autonomic disorders, conditions
accompanied by muscle hypercontractility and certain types of pain. Antinociceptive effect of BoNT-A was long
considered to be the consequence of solely peripheral inhibition of neurotransmitter exocytosis, but nowadays it is
believed that more complex and still unresolved mechanisms are at play. The aim of this study was to investigate the
possibility of transcytosis as a mechanism underlying the complex central action of BoNT-A on pain. BoNT-A (7
IU/kg) was unilaterally administered in the facial vibrissae of Wistar rats a day before the injection of antibody against
BoNT-A (5 IU/10μL) inside the cisterna magna. After seven days, pain was caused by formalin application (2.5%) and
the frequency of pain-associated behaviours was measured at 5-minute intervals over a period of 45 minutes.
Peripherally applied BoNT-A reduced pain during the second phase of formalin test, corresponding to early
inflammatory pain. Anti-BoNT-A prevented antinociceptive effect of BoNT-A, proposing central effects, mediated by
transcytosis. Since the application of colchicine, an axonal transport blocker, in the contralateral trigeminal ganglion
did not affect the antinociceptive effect of BoNT-A, possibility of peripheral diffusion of toxin and systemic spread to
the contralateral side was excluded. Additionally, when BT-A was applied on the opposite side of the pain induction
site, an antinociceptive effect was observed during the inflammatory phase of the formalin test, indicating that the
contralateral effect of BT-A on pain is independent of the site of injury and the action of toxin on the site of
application. In conclusion, the results presented in this master’s thesis contribute to the elucidation of the complex
central action of BoNT-A on pain. For the first time, transcytosis in the sensory system is proposed as an important
factor in the antinociceptive effect of BT-A, which requires further detailed investigation
Vícečetné zarovnávání sekvencí
No full textNázev práce: Vícečetné zarovnávání sekvencí Autor: Matej Ferenc Katedra (ústav): Katedra aplikované matematiky Vedoucí bakalářské práce: RNDr. Ondřej Pangrác, Ph.D. e-mail vedoucího: [email protected] Abstrakt: V práci študujeme problém zarovnania viacerých proteínových alebo DNA sekvencií. Existuje mnoho prístupov k jeho riešeniu, pričom niektoré algoritmy sú optimalizované na rýchlosť, iné na kvalitu zarovnania. Implementujeme dve metódy - iteratívnu a progresívnu, ktoré vychádzajú z rovnakého princípu: použiť vývojové stromy, pomocou ktorých zostavíme zarovnanie. Zavedieme niekoľko metód na výpočet vzdialenosti sekvencií. Cieľom práce je porovnať jednotlivé metódy pre zarovnanie a zistiť, kedy je ich vhodné použiť a tiež nájsť parametre, pomocou ktorých dosiahneme najlepšie výsledky zarovnania. Klíčová slova: bioinformatika, zarovnanie, sekvencieTitle: Multiple Sequence Alignment Author: Matej Ferenc Department: Department of Applied Mathematics Supervisor: RNDr. Ondřej Pangrác, Ph.D. Supervisor's e-mail address: [email protected] Abstract: In this work we study multiple sequence alignment problem, for aligning protein or DNA sequences. There is a lot of ways how to solve this problem. Some of them are optimized for speed, while others are optimized for quality of the produced alignment. We implement two methods - progressive and iterative, which are based on creating a phylogeny tree and align sequences according to it. We will also provide a few distance methods. Our aim is to compare the methods and their parameters for creating best alignments and to find out, when to use which methods. Keywords: bioinformatics, alignment, sequencesDepartment of Applied MathematicsKatedra aplikované matematikyFaculty of Mathematics and PhysicsMatematicko-fyzikální fakult
Hudební efekty
No full textNázov práce: Hudobné efekty Autor: Matej Marko Katedra (ústav): Katedra aplikovanej matematiky Vedúci baklárskej práce: Mgr. Martin Bálek e-mail vedúceho: [email protected] Abstrakt: Efekty zohrávajú v procese tvorby hudby významnú úlohu. Pomáhajú doplniť a obohatiť aranžmán skladby. Cieľom práce je vyvinúť aplikáciu, ktorá umožní užívateľovi prehrať zvukový súbor a v reálnom čase na prehrávaný obsah aplikovať zvolené efekty. Každá zmena v nastavení efektov sa tak ihneď prejaví na výslednom zvuku a užívateľ ju môže okamžite posúdiť. Konkrétne nastavenie môže užívateľ aplikovať na celý vstupný súbor a tento výsledok uložiť. Súčasťou aplikácie je tiež implementácia vybraných efektov. V texte práce sa potom zameriavame na postupy, ktoré sú použité pri implementovaní týchto efektov. Kľúčové slová: efekty, hudba, zvukTitle: Music effects Author: Matej Marko Department: Department of applied mathematics Supervisor: Mgr. Martin Bálek Supervisor's e-mail address: [email protected] Abstract: The effects have crucial position in the proccess of creating music. They enrich song's arrangement and make it all more colorful. Aim of the work is to create application that allows the user to play a sound file and apply chosen effets on it's content in real-time. All changes in effects' settings are imidiatelly transformed into the hearable results. Certain settings can be applied on the whole file and the results afterwards exported to the file. Part of the application is naturally implementation of chosen effects. Main topic of the work's text are methods used to implement the effects. Keywords: effects, music, soundDepartment of Applied MathematicsKatedra aplikované matematikyFaculty of Mathematics and PhysicsMatematicko-fyzikální fakult
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