1,720,966 research outputs found
Pioderma gangrenoso paradosso da Abatacept.
No full textIl pioderma gangrenoso è una rara dermatosi neutrofilica non infettiva
che colpisce solitamente gli arti inferiori. Si presenta più comunemente
con pustole sterili che evolvono in ulcerazioni dolorose con bordi sottominati
eritemato-violacei. È spesso associato a malattie autoimmuni e
può insorgere secondariamente all’utilizzo di farmaci. Una donna di 68
anni affetta da artrite reumatoide long standing (non responsiva a molteplici
terapie convenzionali e biologiche) sviluppava, in corso di terapia
con Abatacept, elementi eritemato-nodulari a livello delle gambe che
andavano incontro a rapida ulcerazione; la diagnosi istologica deponeva
per pioderma gangrenoso. Si instaurava, pertanto, terapia steroidea sistemica
con progressivo miglioramento del quadro cutaneo e si sospendeva
Abatacept, sospettando suo eventuale ruolo eziologico. Abatacept è una
proteina di fusione costituita dalla porzione Fc modificata di IgG1 e dal
dominio extracellulare di CTLA-4; si lega a CD80/86, espresse su APC,
inattivando la via di costimolazione mediata dell’interazione tra il recettore
CD28 (espresso sui linfociti T) e le molecole CD80/86. L’insorgenza
del pioderma gangrenoso (ritenuta patologia autoinfiammatoria), durante
terapia con Abatacept, si configura come effetto paradosso in considerazione
dell’azione immunoregolatrice del farmaco. La patogenesi di tale
nesso causale resta ignota; non sono ancora noti i pathway immunologici
coinvolti
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Allergic contact dermatitis caused by isobornyl acrylate in a young diabetic patient using a continous glucose monitoring system (Freestyle Libre)
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Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Occupational systemic allergic dermatitis in a football player sensitized to colophonium
No full textColophonium, also known as rosin, is a solid yellowish-transparent pine tree resin. It is used in the production of adhesives, in particular glues, mastics, insulating tapes, adhesive tapes, cosmetics, and products for depilation. Contact allergy to colophonium is relatively common and apparently increasing in frequency. We report an unusual case of systemic occupational allergic dermatitis in a professional football player
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dermoscopy of patch test reactions: study of applicability in differential diagnosis between allergic and irritant reactions
No full textBackground: differentiating allergic from irritant patch test reactions may be rather hard, especially when objective features are not distinctive and clinical assessment is scarcely supportive.
Objectives: to describe the main dermoscopic features of patch test reactions and to assess the suitability of dermoscopy in differentiating allergic from irritant reactions in clinical setting.
Patients/Materials/Methods: consecutive adult outpatients patch tested at our Allergy Unit during a 6-month period who developed any skin reaction were eligible. At the 72-hour reading, allergic and irritant patch test reactions were captured with both a digital camera and a digital dermoscopic system. For each reaction, clinical and dermoscopic variables were separately assessed, scored and then compared.
Results: in 94 allergic reactions dermoscopy showed i) intense erythema (100%), ii) dense polymorphic vessels (97.9%), iii) whitish vesicles varying in size, number and arrangement (95.7%), iv) orange-yellowish patchy areas and crusts (35%). Scores of erythema and vessels were significantly higher in allergic than in the 33 irritant reactions, in which vesicles and orange-yellowish patches were a sporadic finding. “Poral pattern” was observed in 85.7% of irritant reactions to cobalt.
Conclusions: the dermoscopic patterns of allergic and irritant patch test reactions significantly differ. Highly sensitive and/or specific dermoscopic features may support differential diagnosis
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