1,721,098 research outputs found
Variability of efficacy measures in Alzheimer's disease
No full textThe efficacy of medical interventions is their capacity of inducing positive modifications of the natural history of diseases. The natural history of dementia is marked by specific events related to the cognitive and functional decline, but their occurrence is poorly predictable in individual patients being highly variable from patient to patient. For this reason it is difficult that the modest efficacy of available interventions for dementia, or their entity measured by clinical scales, may be perceived in clinical practice or in observational studies. Moreover in randomized clinical studies, the effect of this variability, in analogy to misclassification of exposition and/or disease in case control or cohort epidemiological studies, is that of an underestimation of the true efficacy of interventions
An Italian multicentre randomized study on early treatment of Parkinson disease: Comparison of L-dopa, L-deprenyl and dopamine-agonists. Study design and preliminary results.
No full text
Compliance with hand hygiene recommendations during neuromotor rehabilitation procedures in an Italian rehabilitation hospital: An observational study
No full textThis report examines hand hygiene practices among 171 therapists from an Italian hospital for neuromotor rehabilitation, the Fondazione Santa Lucia of Rome. Compliance with hand hygiene measures was
assessed by direct observation during daily neurorehabilitative activities. This study highlights that attention to this task is generally poor among therapist
Italian Neurological Society guidelines for the diagnosis of dementia: revison I
No full textThe objective of this study was to verify the adherence of Italian family physicians and neurologists to the Guidelines on Diagnosis of Dementia of the Italian Society of Neurology. A multicentre survey was carried out, in 72 neurological centres. The centres included at least 15 consecutive subjects suspected of having a dementia. The adherence of family physicians to the guidelines was poor. Neurologists performed a complete neuropsychological evaluation in a minority of the cases. Patients who had a decrease of Mini Mental Status Examination scores after six months higher than or equal to 4 were more represented among those patients for whom one or more recommendations were not respected. In Italy the adherence to the Guidelines on Diagnosis of Dementia and AlzheimerValidation studys Disease of the Italian Society of Neurology is very poor for family physicians (GPs) and satisfactory, albeit improvable, on the part of neurologists. Respect for the guidelines might improve the outcome of patients with dementia
Nuove prospettive e nuovi problemi nell' epidemiologia della corea di Huntington.
No full textIncidenza della Corea di Huntington nella provincia di Ferrar
Early and long-term outcome of rehabilitation in stroke patients: The role of patient characteristics, time of initiation, and duration of interventions
No full textObjective: To determine whether and how patient characteristics and the time of initiation and duration of rehabilitation influence early and long-term patient outcome after cerebrovascular accident. Design: A cohort study. Setting: Twenty rehabilitation hospitals and wards located throughout Italy. Participants: A total of 1716 stroke patients (874 men, 842 women) consecutively admitted to Italian hospital rehabilitation centers in 1997 and 1998. Patients had moderate to severe disability (FIM(TM) instrument score, less than or equal to90). Interventions: Not applicable. Main Outcome Measures: Three negative patient outcomes were considered: death, early failure (premature, unwanted interruption of rehabilitation program; absence of any improvement at hospital discharge), and late failure in terms of severe disability (Barthel Index score, <40) or poor quality of life (Medical Outcomes Study 36-Item Short-Form Health Survey; questionnaire score, <80) 6 months after admission. The strength of the association between the considered variables and the outcomes was calculated with the odds ratio (OR). Results: The less disabled and younger patients had better survival and early and long-term outcomes. The presence of dementia and pressure ulcers on admission was associated with worse outcomes (OR for any failure or death=1.31; 95% confidence interval [CI], 1.03-1.67; OR= 1.63; 95% Cl, 1.12-2.37, respectively). Patients who initiated the rehabilitative procedures early (within 7d after stroke) had better long-term outcomes than did those who initiated the rehabilitation after more than 1 month (OR=2.12; 95% Cl, 1.35-3.34) or from 15 to 30 days after the acute cerebrovascular event (OR=2.11; 95% Cl, 1.37-3.26). Conclusions: This study's results support the idea that recovery after stroke is greatly influenced by the clinical and demographic characteristics of the patients and that early rehabilitation intervention may have a relevant role
The italian sepsis study: preliminary results on the incidence and evolution of SIRS sepsis, severe sepsis and septic shock
No full textSepsis study grou
The italian sepsis study: preliminary results on the incidence and evolution of SIRS sepsis, severe sepsis and septic shock
No full textSepsis study grou
Validation of the Guidelines for the Diagnosis of Dementia and Alzheimer's Disease of the Italian Neurological Society. Study in 72 Italian neurological centres and 1549 patients
No full textThe objective of this study was to verify the adherence of Italian family physicians and neurologists to the Guidelines on Diagnosis of Dementia of the Italian Society of Neurology. A multicentre survey was carried out, in 72 neurological centres. The centres included at least 15 consecutive subjects suspected of having a dementia. The adherence of family physicians to the guidelines was poor. Neurologists performed a complete neuropsychological evaluation in a minority of the cases. Patients who had a decrease of Mini Mental Status Examination scores after six months higher than or equal to 4 were more represented among those patients for whom one or more recommendations were not respected. In Italy the adherence to the Guidelines on Diagnosis of Dementia and AlzheimerValidation studys Disease of the Italian Society of Neurology is very poor for family physicians (GPs) and satisfactory, albeit improvable, on the part of neurologists. Respect for the guidelines might improve the outcome of patients with dementia
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