1,720,968 research outputs found
The long road to the use of microscope in clinical medicine in vivo: From early pioneering proposals to the modern perspectives of optical biopsy
Full text linkFor a long period the scientists did not recognized the potentialities of the compound microscope in medicine. Only few scientists recognized the potentialities of the microscope for the medicine; among them G. Campani who proposed the utilization of his microscope to investigate the skin lesions directly on the patient. The proposal was illustrated in a letter Acta Eruditorum of 1686. The recent development of optical techniques, capable of providing in-focus images of an object from different planes with high spatial resolution, significantly increased the diagnostic potential of the microscope directly on the patient
Effects of single or multiple doses of L-carnitine on liver energetic metabolism of rats forced to run
No full textThe effects of treatment with a single dose of L-carnitine and of daily injection of carnitine for one month on liver energetic metabolism in both sedentary and acutely exercised rats were compared. The results show that the treatment with a single dose of carnitine enhances the aerobic metabolism of liver mitochondria in both resting and in running rats. On the contrary, the daily injection of carnitine for one month does not cause any significant effect on the aerobic metabolism of liver. Treatment with single or multiple doses of carnitine does not modify the serum concentration of cholesterol and of triglycerides in comparison with respective controls
An electron microscope study on the proteinaceous material present in lymph nodes in various pathological conditions
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Comparative studies of effects of dehydroepiandrosterone on rat and chicken liver
No full text1. An attempt to identify the cause of decrease of gain in body weight during dehydroepiandrosterone (DHEA) treatment was made comparing the effects of hormone treatment on chickens and rats. 2. Chickens treated with DHEA for 7-10 days do not change their weight gain with respect to controls although their mitochondrial respiration and peroxisomal catalase (index of peroxisomal mass) were increased. 3. Liver cytosolic malic enzyme and sn-glycerol-3-phosphate dehydrogenase were depressed in chickens treated with DHEA in comparison with activities in untreated controls. DHEA treatment did not increase the activity of mitochondrial sn-glycerol 3-phosphate dehydrogenase. 4. In contrast to rat liver cytosolic sn-glycerol-3-phosphate dehydrogenase this enzyme in chicken liver was inactive with NADPH
Changes in liver structure and function after short-term and long-term treatment of rats with dehydroepiandrosterone
No full textThe effects on the liver of feeding a diet containing 0.2% dehydroepiandrosterone were studied after short (7 d) and long (100 d) periods of treatment in rats. The short-term treatment caused hypertrophy of the hepatocytes that, at the ultrastructural level, seemed to be due to proliferation of peroxisomes and (to a minor extent) of mitochondria. The mitochondria seemed to have undergone transition from expanded to condensed configuration; accordingly, after isolation, their rate of coupled respiration was greater than that of control mitochondria. After long-term treatment, the structure of the hepatocytes reverted toward normal. In fact, at the ultrastructural level, the number and the size of peroxisomes was not significantly different from those of the controls, but degenerative phenomena were observed in the mitochondria. Attempts are made to explain the above ultrastructural and biochemical findings in view of the effects of dehydroepiandrosterone on the energy metabolism of liver
Effect of amrinone on myocardial mitochondria function.
No full textThe effect of amrinone on cardiac mitochondria of guinea pig was studied. It was found that amrinone does not change the respiratory function of cardiac mitochondria in the presence of alpha-ketoglutarate, whereas it inhibits glutamate oxidation. It was also found that amrinone strongly inhibits the activity of glutamic dehydrogenase of both crude extract from sonicated heart mitochondria and of purified preparation from bovine liver. This inhibition may explain the effect of amrinone on the oxidation of glutamate in mitochondria. These results are discussed in view of https://www.unimore.u-gov.it/unimore/#the contradictory effects of amrinone on cardiac and other tissues
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