10,448 research outputs found
Correspondence: Laura Kephart and Arthur Stupka
No full textThis 1936 correspondence, between Laura Kephart (Mrs. Horace Kephart) and Arthur Stupka, concerns a possible Kephart Memorial. Horace Kephart (1862-1931) was a noted naturalist, woodsman, journalist, and author and promoter of the Great Smoky Mountains National Park. Arthur Stupka (1905-1999) was the first park naturalist to work at the Great Smoky Mountains National Park
Mindscapes: Laura Riding's poetry and poetics /
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão.Esta tese propõe uma leitura revisionista da poesia contemporânea através do exame do caso de um dos mais esquecidos escritores norte-americanos do século XX: Laura (Riding) Jackson (1901-1991). O objetivo é demonstrar que Riding não apenas possuía uma poética definida e singular, mas que ela permanece uma das instâncias mais extremas e paradoxais do modernismo anglo-americano, a ponto de Riding abandonar a escrita da poesia em 1938. Recorrendo a conceitos de "formação do cânone" bem como às noções de "discurso" e "função do autor", em Foucault, investigo a construção do cânone da poesia moderna anglo-americana, recuperando o contexto e as circunstâncias da ocultação de Riding. Enquanto cubro os "discursos" poéticos em circulação na primeira metade do século XX-o "imagismo" de Pound, a "dissociação da sensibilidade", "impersonalidade" e "tradição" de Eliot, a "unidade orgância" e "ambigüidade" da Nova Crítica-ofereço um panorama crítico de modernismos alternativos sendo articulados à época. Minha intenção é demonstrar que os poemas de Riding são expressões vigorosas de um escritor para quem "a mente pensando se torna a força ativa do poema", para usar a apta formulação de Charles Bernstein. Entre minhas descobertas sobre as várias e complexas razões que levaram à não-canonização de Riding estão a hegemonia da Nova Crítica, o exílio voluntário de Riding da cena literária (onde são feitas ou desfeitas as reputações), sua recusa em ser antologiada, bem como em ser explicada em termos críticos que não os dela. Todos esses fatores, mais a "dificuldade" de sua poesia, contribuíram para fazer de Riding "a maior poeta esquecida da poesia norte-americana", como escreveu Kenneth Rexroth. Ajudado pelos insights de dois importantes críticos de poesia norte-americana, Charles Bernstein e Marjorie Perloff, defendo que a "poesia da mente" de Riding-onde o que está em jogo é que o que pensamos ser a nossa realidade-representa uma mudança radical no paradigma da poética modernista: de uma poesia centrada na imagem para uma poesia centrada na linguagem. Focalizando a experiência consciente e o tempo duracional do pensamento presente em seus poemas, concluo que as "pensagens" de Riding têm o objetivo preciso de constatar um fato universal: enquanto seres humanos e pensantes, estamos numa condição permanente chamada linguagem
Letter, Julia Gardiner Tyler to Mrs. Laura Holloway, author of First Ladies, dated September 20, 1869
No full textALS of Julia Gardiner Tyler to Mrs. Laura Holloway, author of First Ladies, dated September 20, 1869, about interviewing other first ladies. ALS.Found in:Mss. 65 T97 Additions, Series 1: Mss. Acc. 1993.19 Addition, 186
Heritage tourism: a case study of the Laura Ingalls Wilder Heritage Site at Pepin, Wisconsin
No full textPlan BMany things must be taken into consideration when developing a heritage tourism site. It can be a wonderful opportunity for the community involved to benefit economically and historically. Heritage tourism can keep alive the heritage and traditions of the communities past. When it is discovered that a heritage site exists, the first step is to consult with the community. A site will not succeed without the acceptance and assistance from the community involved. Once the interest is known, the development process can proceed. After determining that there is a heritage tourism site possibility in their area, a commumity must do research to determine the feasibility of the site, what will make it a success, and how to obtain that success. This study will examine a community with a heritage tourism site that has been successful in developing and maintaining it's site. By conducting this study, other communities seeking information for developing their site will have an example and tool to work with. The site chosen for this study is the Laura Ingalls Wilder site in Pepin, Wisconsin. The town is rich with it's heritage associated with Laura Ingalls Wilder. The development and success for this town will be documented through this study. Laura Ingails Wilder is a perfect choice for examining heritage tourism. The author of many American Pioneer books, she has become famous all over the world. In turn all places that she or her family members lived are or are becoming heritage tourism sites. There are older ones that have been in progress for some years, such as the one in Pepin, and there are ones that are being discovered through the popularity of new books written about Laura's family. These communities would benefi greatly from the information this study will produce. Without the bene-fit of this knowledge communities who are unaccustomed to tourism or the way the other Laura Ingalls Wilder sites operate, may make terrible errors in development, tarnishing the site. This may also reflect badly on the other Laura Ingalls Wilder sites. It is important for new Wilder sites to examine all information and know exactly what they are doing when developing the site. If all the Laura Ingalls Wilder sites can benefit from each other's knowledge and experience it will greatly increase the market for all sites. The more detailed and expansive the sites are about their knowledge and sites to see, the more people are going to want to travel to as many sites as possible, learning all they can about the life of Laura Ingalls Wilder and her family. These sites not only attract Laura Ingalls Wilder fans but all people that are interested in the American Pioneer period of the United States history. This study will provide the knowledge for communities who are developing heritage tourism sites, especially those focusing on Laura Ingalls Wilder. This is a very important study for tourism and especially heritage tourism. When a heritage site is discovered communities run into the barrier of not having the experience and knowledge to develop the site properly. This study will analyze tourism in Pepin, Wisconsin to determine it's successfulness due to the fact that it is a Laura Ingalls Wilder heritage tourism site, and Wfit was developed in a way to provide tourists with a view of Laura Ingalls Wilder's past and the past of many Pioneer Americans. By studying this subject it will allow for many people to benefit. Tourist who are seeking the pleasure of the knowledge of the past, and communities who want to preserve their past and profit from tourism
Core Journal Lists: Classic Tool, New Relevance
No full textReviews the historical context of core journal lists, current uses in collection assessment, and existing methodologies for creating lists. Outlines two next generation core list projects developing new methodologies and integrating novel information/data sources to improve precision: a national-level core psychology list and the other a local institutional core list for the interdisciplinary field of urban studies and planning. The paper is based on the authors’ panel presentation at the 2009 ACRL National Conference (Seattle, Washington) titled “Core Journal Lists Re-viewed and Re-imagined.”This is an electronic version of an article published in Robin A. Paynter, Rose M. Jackson & Laura Bowering Mullen (2010): Core Journal Lists: Classic Tool, New Relevance, Behavioral & Social Sciences Librarian, 29:1, 15-31. Behavioral & Social Sciences Librarian is available online at: http://www.tandfonline.com, http://dx.doi.org/10.1080/01639260903571096Peer reviewe
miRNA Editing: New Insights into the Fast Control of Gene Expression in Health and Disease
No full textPost-transcriptional modifications are essential mechanisms for mRNA biogenesis and function in eukaryotic cells. Beyond well-characterized events such as splicing, capping, and polyadenylation, there are several others, as RNA editing mechanisms and regulation of transcription mediated by miRNAs that are taking increasing attention in the last years. RNA editing through A-to-I deamination increases transcriptomic complexity, generating different proteins with amino acid substitution from the same transcript. On the other hand, miRNAs can regulate gene expression modulating target mRNA decay and translation. Interestingly, recent studies highlight the possibility that miRNAs might undergo editing themselves. This mainly translates in the degradation or uncorrected maturation of miRNAs but also in the recognition of different targets. The presence of edited and unedited forms of the same miRNA may have important biological implications in both health and disease. Here we review ongoing investigations on miRNA RNA editing with the aim to shed light on the growing importance of this mechanism in adding complexity to post-transcriptional regulation of gene expression
Stress, microRNAs, and stress-related psychiatric disorders: an overview
No full textStress is a major risk factor for psychiatric disorders. During and after exposure to stressors, the stress response may have pro- or maladaptive consequences, depending on several factors related to the individual response and nature of the stressor. However, the mechanisms mediating the long-term effects of exposure to stress, which may ultimately lead to the development of stress-related disorders, are still largely unknown. Epigenetic mechanisms have been shown to mediate the effects of the environment on brain gene expression and behavior. MicroRNAs, small non-coding RNAs estimated to control the expression of about 60% of all genes by post-transcriptional regulation, are a fundamental epigenetic mechanism. Many microRNAs are expressed in the brain, where they work as fine-tuners of gene expression, with a key role in the regulation of homeostatic balance, and a likely influence on pro- or maladaptive brain changes. Here we have selected a number of microRNAs, which have been strongly implicated as mediators of the effects of stress in the brain and in the development of stress-related psychiatric disorders. For all of them recent evidence is reported, obtained from rodent stress models, manipulation of microRNAs levels with related behavioral changes, and clinical studies of stress-related psychiatric disorders. Moreover, we have performed a bioinformatic analysis of the predicted brain-expressed target genes of the microRNAs discussed, and found a central role for mechanisms involved in the regulation of synaptic function. The complex regulatory role of microRNAs has suggested their use as biomarkers for diagnosis and treatment response, as well as possible therapeutic drugs. While, microRNA-based diagnostics have registered advancements, particularly in oncology and other fields, and many biotech companies have launched miRNA therapeutics in their development pipeline, the development of microRNA-based tests and drugs for brain disorders is comparatively slower
Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies
No full textEnvironmental stressors induce coping strategies in the majority of individuals. The stress response, involving the activation of the hypothalamic-pituitary-adrenocortical axis and the consequent release of corticosteroid hormones, is indeed aimed at promoting metabolic, functional, and behavioral adaptations. However, behavioral stress is also associated with fast and long-lasting neurochemical, structural, and behavioral changes, leading to long-term remodeling of glutamate transmission, and increased susceptibility to neuropsychiatric disorders. Of note, early-life events, both in utero and during the early postnatal life, trigger reprogramming of the stress response, which is often associated with loss of stress resilience and ensuing neurobehavioral (mal)adaptations. Indeed, adverse experiences in early life are known to induce long-term stress-related neuropsychiatric disorders in vulnerable individuals. Here, we discuss recent findings about stress remodeling of excitatory neurotransmission and brain morphology in animal models of behavioral stress. These changes are likely driven by epigenetic factors that lie at the core of the stress-response reprogramming in individuals with a history of perinatal stress. We propose that reprogramming mechanisms may underlie the reorganization of excitatory neurotransmission in the short- and long-term response to stressful stimuli
Changes in AMPA and NMDA receptors associated with stress vulnerability/resilience and ketamine treatment in a chronic mild stress rat model of depression
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