121 research outputs found
HCA Healthcare Scholarly Commons: Assembling a Knowledge Menagerie
No full textHCA Healthcare Scholarly Commons is the institutional repository for HCA Healthcare Graduate Medical Education programs. Utilizing the bepress Digital Commons platform, our repository houses scholarly works from over 300 residency and fellowship programs at 66 teaching hospitals nationwide. During the presentation, the institutional repository manager will discuss using Scholarly Commons to create traditional collections and various writing education and scholarly activity initiatives housed in the repository. Collections discussed will include:
1. The Write Way: A Peer Review Panel This is an online peer-review platform for HCA Healthcare GME residents, fellows, and faculty; participants can serve as a reviewer and/or submit an article for review as an author to receive feedback. 2. Teaching Commons - A new initiative that creates shared curriculum resources for the HCA Healthcare GME enterprise. 3. HCA Healthcare Online Writing Lab (HOWL) .“ A collection of writing resources created by the HCA Healthcare GME medical writer and the knowledge management team. Resources currently include modules on Plagiarism Prevention, Authorship, Writing Effective Poster Presentations, and more.
The presentation will discuss the process and workflow for creating these collections and the challenges encountered.
This research was supported (in whole or in part) by HCA Healthcare and/or an HCA Healthcare-affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities
HCA Healthcare Scholarly Commons: Assembling a Knowledge Menagerie
No full textHCA Healthcare Scholarly Commons is the institutional repository for HCA Healthcare Graduate Medical Education programs. Utilizing the bepress Digital Commons platform, our repository houses scholarly works from over 300 residency and fellowship programs at 66 teaching hospitals nationwide. During the presentation, the institutional repository manager will discuss using Scholarly Commons to create traditional collections and various writing education and scholarly activity initiatives housed in the repository. Collections discussed will include:
1. The Write Way: A Peer Review Panel This is an online peer-review platform for HCA Healthcare GME residents, fellows, and faculty; participants can serve as a reviewer and/or submit an article for review as an author to receive feedback. 2. Teaching Commons - A new initiative that creates shared curriculum resources for the HCA Healthcare GME enterprise. 3. HCA Healthcare Online Writing Lab (HOWL) .“ A collection of writing resources created by the HCA Healthcare GME medical writer and the knowledge management team. Resources currently include modules on Plagiarism Prevention, Authorship, Writing Effective Poster Presentations, and more.
The presentation will discuss the process and workflow for creating these collections and the challenges encountered.
This research was supported (in whole or in part) by HCA Healthcare and/or an HCA Healthcare-affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities
Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes
No full textThe synthesis of a new series of sulfamides incorporating ortho-, meta, and para-benzenesulfamide moieties is reported, which were investigated for the inhibition of two human (h) isoforms of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I and II, and two Vibrio cholerae enzymes, belonging to the α- and β-CA classes (VchCAα, VchCAβ). The compounds were prepared by using the “tail approach”, aiming to overcome the scarcity of selective inhibition profiles associated to CA inhibitors belonging to the zinc binders. The built structure–activity relationship showed that the incorporation of benzhydryl piperazine tails on a phenyl sulfamide scaffold determines rather good efficacies against hCA I and VchCAα, with several compounds showing KIs < 100 nM. The activity was lower against hCA II and VchCAβ, probably due to the fact that the incorporated tails are quite bulky. The obtained evidences allow us to continue the investigations of different tails/zinc binding groups, with the purpose to increase the effectiveness/selectivity of such inhibitors against bacterial CAs from pathogens, affording thus potential new anti-infectives
The practice of access pricing : telecommunications in the United Kingdom
No full textTelecommunications was the first network utility to be privatized in the United Kingdom. Drawing on 15 years'experience and discussion in the field, the author shows the economic principles of regulation in general and access pricing in particular that have been implemented. British Telecommunications (BT), formed as a public enterprise in 1980-81, was privatized in 1984. Since then the approaches to regulation have changed in three broad periods: the duoply, the transition to competition, and the recently introduced normalization phase. Dealing with each period, the author focuses on how the actual implementation of access charges are determined, at the same time providing background needed on regulatory intervention generally. Rather than follow the model of competition for a common infrastructure, Oftel [the Office of Telecommunications, the regulatory agency]has encouraged competition between alternative networks, which benefits customers but involves duplication of fixed costs. As a result of Oftel's approach, customers have seen their bills reduced 50 percent in real terms since privatization. It is difficult to know how much to attribute this remarkable result to technological progress (BT halved its workforce in the same period), to regulatory intervention (Oftel set string caps until 1997), or to competition (there are hundreds of players in the market). The author contends more weight should probably be given to the first two. Entrants have not achieved big market shares, if one considers the asymmetric regulation that has been in place for more than a decade. Indirectly, at least, competition benefited consumers by applying discipline to BT's behavior. Oftel's approach was interventionist until 1997, when it began trying to normalize the industry, as authority overseeing competition. The odds on complete deregulation are slight, and some controls on industry will remain. In the longer term, Oftel should especially monitor anticompetitive practices and collusive behavior among the bigger players (BT, CWC, and cellulator operators), The United Kingdom's interconnection experience demonstrates the complexity of the problem and its relationship to other topics, such as tariff rebalancing, access deficit, and universal service. Although a bit ad hoc, the recent incentive regulation, with a network cap based on proper accounting procedures and engineering models, may represent the best practice available today in the telecommunications industry, says the author.Public Sector Economics&Finance,Decentralization,Knowledge Economy,Economic Theory&Research,Payment Systems&Infrastructure,Public Sector Economics&Finance,Education for the Knowledge Economy,Knowledge Economy,Economic Theory&Research,ICT Policy and Strategies
Solar PV hosting capacity: Grid-based vs. market-based scenarios
No full textAssessing the capability of a distribution grid to accommodate new solar PV installations, namely its hosting capacity (HC), has been a prevalent research topic. Although providing a technical limit to how much additional solar PV can be integrated into a distribution grid without trespassing operational limits, commonly used HC analysis (HCA) does not consider consumer preferences or the economic feasibility of installations. Using a market-based optimal power flow (MBOPF) and HCA, we compare the economic and technical limits of solar PV capacity integration in low voltage distribution systems (LVDS). Findings illustrate that (1) the PV HC computed using grid limits only does not give a complete picture of solar PV capacity integration potential, (2) linear, deterministic power flow is not a foolproof method for assessing the network-secure amount of PV, and (3) the number of technically feasible installation sites supersedes the economically feasible ones.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Energy and Industr
Health Hazard Evaluation Report: HETA-93-0582-2359: HCA Wesley Medical Center; Wichita, Kansas
No full textIn response to a request from the respiratory therapist educator of HCA Wesley Medical Center in Wichita, Kansas, an evaluation was conducted of the effectiveness of revised procedures for administering ribavirin (36791045) via hood. The containment system consisted of a cubical care cube disposable hood, an aerosol generator for ribavirin administration, and a second hood which was placed over the care cube and connected to a scavenging system. Air sampling was conducted within the care cube disposable hood, and area air samples were collected at five locations within the room. A respiratory therapist simulated the activities that would normally have been necessary if a patient were actually receiving care, but did so using an infant mannequin. Area samples showed either nondetectable or trace concentrations of ribavirin. In hood concentrations of ribavirin ranged from 33 to 92mg/m3. The air exchange rate of each room exceeded the minimum of six air changes per hour. The author concludes that the double hood system in place appeared to be effective for preventing the release of ribavirin aerosol into the work environment. The author suggests that the ventilation system of each room where ribavirin is administered be monitored on a routine basis to ensure that optimal operation is maintained
Preoperative biliary drainage for hilar cholangiocarcinoma : which stent should be selected?
No full textThe controversy over whether and how to perform preoperative biliary drainage (PBD) in patients with hilar cholangiocarcinoma (HCA) remains unsettled. Arguments against PBD before pancreatoduodenectomy have recently been gaining momentum. However, the complication-related mortality rate is as high as 10% for patients with HCA who have undergone major liver resection, and liver failure is a major cause of postoperative death. This suggest the need for PBD to treat jaundice in HCA patients scheduled for major surgical resection of the liver and to perform major surgery only after recovery of hepatic function. No definite criteria or guidelines outlining indications for PBD are currently available. In patients with HCA, PBD may be performed by either percutaneous transhepatic biliary drainage (PTBD) or endoscopic biliary drainage (EBD). No consensus, however, has been reached regarding which drainage method is more appropriate. No reported study has compared the effectiveness of PTBD, endoscopic biliary stenting (EBS), and endoscopic nasobiliary drainage (ENBD) in patients with HCA. This review summarizes the results of our study comparing the three methods and outlines the preoperative endoscopic management of segmental cholangitis (SC) in HCA patients undergoing PBD
HCA 693 Capstone Project
No full textThis paper documents a project involving at-home HIV and STI testing undertaken by the HIV Care and Prevention team at Lifelong Medical Care and co-managed by the author
Health Hazard Evaluation Report: HETA-90-155-2169: HCA Wesley Medical Center; Wichita, Kansas
No full textIn response to a request from the respiratory therapist educator of HCA Wesley Medical Center (SIC-8062), Wichita, Kansas, an evaluation was made of methods used to control exposures of respiratory therapists and nurses to aerosolized ribavirin (36791045). The facility had about 3000 full time and part time workers. The Pediatric Intensive Care Unit, where ribavirin is sometimes used, had 18 beds. Three visits were made to the site. During the first visit exposures of therapists and nurses to ribavirin was monitored during aerosol administration with infant mannequins. Area samples were collected within the Care Cube disposable hoods used for administration of ribavirin, beside beds to which the hoods were located, and at a location where no exposure was expected. Personal exposure monitoring was conducted for four respiratory therapists and two nurses. Additional measurements were taken on the second and third visits. The author concludes that notable concentrations of aerosolized ribavirin were present in the rooms where the drug was administered despite the addition of a scavenging system to the Care Cube disposable hood. High efficiency air purifying respirators approved by NIOSH/MSHA and assigned to employees based on the results of quantitative fit tests were found to reduce exposures to the limit of detection of the analytical method used. The author recommends that the use of these respirators continue and that a complete respiratory protection program be initiated at this site
Clouds and cloud radiative forcing over tropical Indian Ocean and their relationship with sea surface temperature
No full textEarth radiation budget experiment (ERBE) radiative fluxes and International Satellite Cloud Climatology Project (ISCCP) C-2 cloud parameters for the four representative months of January, April, July and October and for the period 1985-1988 are used to study the cloud-radiation interaction over the tropical Indian Ocean (20° S-20° N, 50° E-100° E), and its relationship with sea surface temperature (SST). Some important results are compared with those over tropical west Pacific Ocean (20° S-20° N, 130° E-180° E). Over Indian Ocean, both the shortwave cloud radiative forcing (SWCRF) and longwave cloud radiative forcing (LWCRF) are found to be correlated most with high cloud amounts (HCA) among the various cloud types. HCA and cloud radiative forcings in turn show a positive relationship with SST above 26.4°C. During July and October, after reaching a maximum value at 29°C, the relationship is found to be negative. In the rising portion of the HCA-SST relationship, at certain SST threshold value (27.4°C for July) the probability of occurrence of high convective clouds suddenly rises above 50. During January and July above this SST threshold value the SWCRF is found to be significantly larger than LWCRF, thus causing large negative net cloud radiative forcing. This is found to be associated with the sudden rise in the spatial extent (cloud amount) and the optical depth of the high clouds above the SST threshold values
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