132,057 research outputs found
Table 1 for Multidisciplinary Care of Epidermolysis Bullosa during the COVID-19 Pandemic – Consensus: Recommendations by an International Panel of Experts
No full textA questionnaire was drafted by DM into a table of suggested modifications to the management of EB during the COVID-19 pandemic. Fifty seven well-known experts on EB were selected based on membership of the international Clin-et group and/or clinical expertise in EB demonstrated at International EB Congress participation. Responses and reasons for each response were requested individually to the lead author based on an ideal scenario, rather than what actually may happen in some centers with financial constraints. A priori, consensus was considered to be the agreement of more than 70% of respondents with the suggestion. Questionnaires were returned by 44 of the 57 EB experts, representing several areas of clinical expertise in EB (dermatology, pediatrics, internal medicine and surgery) from 5 continents. After addition and revision of some items and 3 cycles of revoting, consensus was achieved for all items, which are summarized in this Table. The full details are published in the JAAD -doi: 10.1016/j.jaad.2020.06.102
A role for P2X4 receptors in lysosome function
No full textMurrell-Lagnado provides insight into new research revealing the physiological role of lysosomal P2X4 channels.</jats:p
Jeff D. Griffin, Sr. Collection
No full textPhotograph of the George M. Murrell Home, Tahlequah, OK. Photo by Jeff D. Griffin, Oklahoma Planning & Resources Board. Printed by Bond Lithographing & Printing Co
The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review
No full textOsteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. OA is treated with a wide range of modalities, both conservatively and surgically. Prolotherapy has been used to treat various musculoskeletal problems and has shown some promise
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Methodological considerations for the use of stable isotope probing in microbial ecology
No full textStable isotope probing (SIP) is a method used for labeling uncultivated microorganisms in environmental samples or directly in field studies using substrate enriched with stable isotope (e.g., 13C). After consumption of the substrate, the cells of microorganisms that consumed the substrate become enriched in the isotope. Labeled biomarkers, such as phospholipid-derived fatty acid (PLFA), ribosomal RNA, and DNA can be analyzed with a range of molecular and analytical techniques, and used to identify and characterize the organisms that incorporated the substrate. The advantages and disadvantages of PLFA-SIP, RNA-SIP, and DNA-SIP are presented. Using examples from our laboratory and from the literature, we discuss important methodological considerations for a successful SIP experiment
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