400,985 research outputs found
A combined tree growing technique for block-test scheduling under power constraints
No full textA tree growing technique is used here together with classical scheduling algorithms in order to improve the test concurrency having assigned power dissipation limits. First of all, the problem of unequal-length block-test scheduling under power dissipation constraints is modeled as a tree growing problem. Then a combination of list and force-directed scheduling algorithms is adapted to tackle it. The goal of this approach is to achieve rapidly a test scheduling solution with a near-optimal test application time. This is initially achieved with the list approach. Then the power dissipation distribution of this solution is balanced by using a force-directed global priority function. The force-directed priority function is a distribution-graph based global priority function. A constant additive model is employed for power dissipation analysis and estimation. Based on test scheduling examples, the efficiency of this approach is discussed as compared to the other approaches
Vivier-Muresan Anne-Sophie, Afzâd. Ethnologie d’un village iranien. Téhéran, Éditions Mo’in, Institut Français de Recherche en Iran, 2006
No full textBoissière Thierry. Vivier-Muresan Anne-Sophie, Afzâd. Ethnologie d’un village iranien. Téhéran, Éditions Mo’in, Institut Français de Recherche en Iran, 2006. In: Bulletin critique des annales islamologiques, n°25, 2010. p. 98
La Normandie avant 1066 : quelques lectures contemporaines (1966-2016)
No full textCommunication présentée à la Journée d’études « Le couronnement royal de Guillaume Ier : la Normandie, l’Angleterre, l’Europe » organisé par le GRHIS à Rouen, 30 novembre 2016 (resp. A Grélois, E. Lalou, D. I. Muresan
Where do good query terms come from?
No full textThis paper describes a framework for investigating the quality of different query expansion approaches, and applies it in the HARD TREC experimental setting. The intuition behind our approach is that each topic has an optimal term-based representation, i.e. a set of terms that best describe it, and that the effectiveness of any other representation is correlated with the overlap that it has with the optimal representation. Indeed, we find that, for a wide number of candidate topic representations, obtained through various query-expansion approaches, there is a high correlation between standard effectiveness measures (R-P, P@10, MAP) and term overlap with what is estimated to be the optimal representation. An important conclusion of comparing different query expansion approaches is that machines are better than humans at doing statistical calculations and at
estimating which query terms are more likely to discriminate documents relevant for a given topic. This explains why, in the HARD track of TREC 2005, the overall conclusion was that interaction with the searcher and elicitation of additional
information could not over-perform automatic procedures for query improvement. However, the best results are obtained from hybrid approaches, in which human relevance judgments are used by algorithms for deriving terms representations. This result suggest that the best approach in improving retrieval performance is probably to focus on implicit relevance feedback and novel interaction models based on ostention or mediation, which have shown great potential
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site
No full textRaw data for paper -Muresan, P., P. McCrorie, F. Smith, C. Vasey, V. Taresco, D. J. Scurr, S. Kern, S. Smith, P. Gershkovich, R. Rahman and M. Marlow (2022). "Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site." European Journal of Pharmaceutics and Biopharmaceutics. https://doi.org/10.1016/j.ejpb.2022.11.01
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Role of Scavenger receptor B1 in cutaneous physiopathology
No full textScavenger receptor B1 (SR-B1) è una proteina transmembrana, coinvolta nel trasporto inverso di colesterolo a livello tissutale e definita anche recettore per HDL. Diversi studi hanno dimostrato che SR-B1 è implicato anche in altri processi, come regolazione dei livelli intracellulari di vitamine, riconoscimento di batteri e cellule apoptotiche e internalizzazione di vescicole. Nonostante il recettore sia localizzato principalmente a livello del fegato e dei tessuti steroidogenici, esso è significativamente espresso anche in altri tessuti compresa la cute umana, in special modo nell’epidermide. L’epidermide conferisce alla cute la funzione di barriera, attraverso la presenza dello strato corneo composto da acidi grassi, colesterolo, ceramidi, proteine e corneociti, quest’ultimi racchiusi da un involucro lipidico. La sua localizzazione e composizione fa della pelle un bersaglio per i fattori di stress ambientali. Studi in vitro condotti su cheratinociti in coltura hanno mostrato che stressors ambientali quali il fumo da sigaretta riducono l’espressione del recettore. Lo scopo del presente studio è stato quello di valutare il ruolo fisiologico di SR-B1 nella cute, attraverso l’uso di modelli cutanei 2D e 3D in cui l’espressione di SRB1 è stata geneticamente manipolata. I nostri dati dimostrano che SR-B1 è coinvolto nella proliferazione e nella migrazione cellulare. Infatti, il silenziamento di SR-B1 ha indotto una diminuzione dell’espressione di ciclina D1, così come dei livelli di MMP9 accompagnati da un difetto nella riorganizzazione del citoscheletro, influenzando perciò la capacità dei cheratinociti di riparare la ferita. Inoltre, SR-B1-KO ha un effetto sull’attivazione di NF-kB ed inoltre in modelli tridimensionali di cute ha causato cambiamenti sia a livello dello spessore che nella morfologia degli strati epidermici, insieme ad un aumento dei marcatori di differenziamento cellulare. In aggiunta, il recettore sembra avere un ruolo anche nella distribuzione epidermica dei lipidi e sul tipo di lipidi oltre ad essere implicato anche nel metabolismo lipidico nei sebociti. In fine il nostro studio ha dimostrato che i fattori di stress ambientali portano ad una riduzione di SR-B1 e questo effetto è evitato dall’uso di molecole naturali quali il resveratrolo. Riassumendo, i nostri dati suggeriscono che SR-B1 gioca un ruolo importante nella cicatrizzazione, così come nel differenziamento epidermico e nella composizione lipidica della cute, perciò la sua perdita indotta dall’esposizione ad agenti ossidanti potrebbe influenzare l’omeostasi cutanea.Scavenger receptor B1 (SR-B1) is a trans-membrane protein, known as HDLs main receptor and involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other processes, such as regulation of intracellular vitamins levels, recognition of bacteria and apoptotic cells and vesicles uptake. Although this receptor is mainly localized in the liver and steroidogenic tissues, it is significantly expressed also in human skin, especially in the epidermis. The epidermis provides the barrier function of skin, due to the presence of stratum corneum, composed by proteins and corneocytes, which are distributed in a lipid envelope. Its localization and composition makes the skin a target for environmetantal stressors. In vitro studies on cultured keratinocytes have shown that SR-B1 protein expression is down-regulated by environmental oxidants such as cigarette smoke. Therefore, the purpose of our study was to evaluate the physiological role of SR-B1 in the skin, with more focus on the not vascularized cutaneous epidermal layer, by using 2D and 3D skin models. We demonstrated that SR-B1 is involved in cellular proliferation and migration, since SR-B1 knockdown keratinocytes presented reduced capacity to proliferate and migrate. In fact, SR-B1 knockdown induced a decrease of Cyclin D1 expression, as well as MMP9 levels accompanied by a defect in cytoskeleton rearrangement, affecting keratinocytes ability to recover from wound scratch. Furthermore, SR-B1 appeared to affect NF-kB activation. SR-B1 knockdown in tridimensional organotypic skin equivalents induced changes in epidermis thickness and deeper layers morphology, together with increased markers of terminal differentiation. Not only, but the scavenger receptor resulted to be essential for lipids expression and epidermal distribution, and it is implicated also in sebocytes lipids metabolism. Moreover, our study demonstrated that environmental stressors down-regulate SR-B1 also in three-dimensional reconstructed epidermis and human skin and, by the use of a natural polyphenol, we showed that such down-regulation was mediated by oxidative damage. Altogether, our findings suggest that SR-B1 plays an important role in keratinocytes recovery from injuries, as well as in epidermal differentiation and lipid composition, therefore its loss induced by oxidants exposure could affect cutaneous homeostasis
A comparison of classical scheduling approaches in power-constrained block-test scheduling
No full textClassical scheduling approaches are applied here to overcome the problem of unequal-length block-test scheduling under power dissipation constraints. List scheduling-like approaches are proposed first as greedy algorithms to tackle the fore mentioned problem. Then, distribution-graph based approaches are described in order to achieve balanced test concurrency and test power dissipation. An extended tree growing technique is also used in combination with these classical approaches in order to improve the test concurrency having assigned power dissipation limits. A comparison between the results of the test scheduling experiments highlights the advantages and disadvantages of applying different classical scheduling algorithms to the power-constrained test scheduling proble
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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