339 research outputs found
Platelet Function and the Development of Thromboembolic Events After Cerebrovascular Stenting Procedures
No full textIntroduction: One of the biggest concerns associated with endovascular procedures is the development of thromboembolic events. To mitigate this risk, patients are placed on dual antiplatelet therapy. Interestingly, there is a known variation in one’s ability to appropriately respond to antiplatelet medications and patients with decreased responsiveness may be at an increased risk of developing ischemic complications. Routine testing of antiplatelet responsiveness is not performed at most endovascular centres and is still a topic of controversy within the neurosurgical community. The objective of our study was to determine if non-responsiveness to aspirin and clopidogrel was associated with the development of symptomatic thromboembolic events in patients undergoing cerebrovascular stenting procedures. Methods: A prospective study was conducted at the Foothills Medical Centre in Calgary, Alberta, Canada from August 2019 to February 2021. Patients undergoing cerebrovascular stenting procedures and who were on dual antiplatelet therapy consisting of aspirin and clopidogrel were enrolled in the study. Responsiveness to the antiplatelet medications was determined through whole blood impedance aggregometry and the treating neurointerventionalists were blinded to these results. The primary outcome was the development of a symptomatic thromboembolic event at 90 days after the procedure. Demographic, clinical, radiological, and procedural variables were analyzed to determine which factors were associated with the development of thromboembolic events. Results: One hundred and eighteen procedures were performed in 115 patients. The non-response rate of clopidogrel and aspirin was 21% and 14%, respectively. There were 12 (10%) thromboembolic events that occurred during the study period. On the univariable analysis age (p=0.03) and non-responsiveness to clopidogrel (p=0.01) were associated with the development of thromboembolic events, while aspirin non-responsiveness was not (p=0.13). On the multivariable logistic regression only clopidogrel non-responsiveness (OR 3.91, 95%CI 1.05, 14.50, p=0.04) was associated with the development of thromboembolic events. Conclusion: Our study has demonstrated that patients who were identified as clopidogrel non-responders, using whole blood impedance aggregometry, were at an increased risk of developing thromboembolic events. Furthermore, the results of our study validate the need for larger observational studies or randomized controlled trials to assess the utility of platelet function testing prior to cerebrovascular stenting procedures
Proceedings of ASME Turbo Expo 2013: Power for Land, Sea and Air, Volume 1A: Combustion, Fuels and Emissions
No full textShahrokh Etemad (with Sandeep Alavandi and Benjamin Baird) is a contributing author, Fuel Flexible Rich Catalytic Lean Burn System for Low Btu Fuels
Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo
No full textBackground
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation. Growing evidence suggests that specific isoforms of PKC influence a variety of behavioral, biochemical, and physiological effects of ethanol in mammals. The purpose of this study was to determine whether acute ethanol exposure alters phosphorylation of conventional PKC isoforms at a threonine 674 (p-cPKC) site in the hydrophobic domain of the kinase, which is required for its catalytic activity.
Methods
Male rats were administered a dose range of ethanol (0, 0.5, 1, or 2 g/kg, intragastric) and brain tissue was removed 10 minutes later for evaluation of changes in p-cPKC expression using immunohistochemistry and Western blot methods.
Results
Immunohistochemical data show that the highest dose of ethanol (2 g/kg) rapidly increases p-cPKC immunoreactivity specifically in the nucleus accumbens (core and shell), lateral septum, and hippocampus (CA3 and dentate gyrus). Western blot analysis further showed that ethanol (2 g/kg) increased p-cPKC expression in the P2 membrane fraction of tissue from the nucleus accumbens and hippocampus. Although p-cPKC was expressed in numerous other brain regions, including the caudate nucleus, amygdala, and cortex, no changes were observed in response to acute ethanol. Total PKC? immunoreactivity was surveyed throughout the brain and showed no change following acute ethanol injection
Characterizing collagen mimetic peptides for orthogonal self-assembly
No full textA computational design of collagen mimetic peptides (CMPs) that self-assemble orthogonally (mutually exclusively), in the presence of other pre-existing collagen trimer mixtures, in vitro, has been proposed. The orthogonality in self-assembly was brought about by orthogonal patterning of ionic salt bridges and residues, along the collagen trimers’ axial length. Through the aid of circular dichroism spectroscopy alone, a novel experimental protocol was set-up to rapidly assess the level of cross-talk that may arise in such designed ‘heterogeneous monomer to trimer folding’ mixture environments. It is shown that the designed collagen mimetic peptides are stable and hetero-specific within their composite 3 chain peptide ecosystem. We experimentally demonstrate the extent to which loss in specificity could possibly occur, upon moving to a higher order ‘more than 3 monomers in solution’ peptide ensemble. Although the desired level of multi-state orthogonality was not achieved in the current design, the experimental results obtained were used to estimate the stability and specificity barrier threshold that one might run into, if one were to instead design orthogonal systems where-in specificity is incorporated during the computational design stage itself a priori. A Pareto frontier plot indicating the specificity versus stability trade-off is plotted. We conclude that a bottom-up design approach, incorporating design of specificity during the sequence design stage, would be a better way forward for achieving self-assembling orthogonality. In contrast to the complex chaperone assisted protein folding systems existing in nature, our method is a simplistic first step towards the complementary approach of modular synthetic collagen molecule design.Ph.D.Includes bibliographical referencesby Sandeep Vishwanath Belur
Resin and steel-reinforced resin used as injection materials in bolted connections
No full textInjection bolts are bolts in which the cavity produced by the clearance between the bolt and the wall of the hole is completely filled up with a two-component resin. Filling of the clearance is carried out through a small hole in the head of the bolt. After injection and complete curing, the connection is slip resistant. Recently the injection material, typically an epoxy resin, was modified at TU Delft by adding steel shots (spherical particles) to mitigate the effects of resin compliance in the shear connection of reusable composite (steel-concrete) structures. Experimental compressive material tests on unconfined/confined resin and steel-reinforced resin are evaluated in this chapter. The uniaxial model which combines damage mechanics and the Ramberg-Osgood relationship is proposed to describe the uniaxial compressive behavior of resin and steel-reinforced resin. First-order numerical homogenization is employed as a high-fidelity model, where a combined nonlinear isotropic/kinematic cyclic hardening model is employed to define the steel plasticity, the linear Drucker-Prager plastic criterion was used to simulate resin damage, and the cohesive surfaces reflecting the relationship between traction and displacement at the interface. The linear Drucker-Prager plastic model is used as a low-fidelity model.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Steel & Composite Structure
Anomaly-Based DNN Model for Intrusion Detection in IoT and Model Explanation: Explainable Artificial Intelligence
No full textIoT has gained immense popularity recently with advancements in technologies and big data. IoT network is dynamically increasing with the addition of devices, and the big data is generated within the network, making the network vulnerable to attacks. Thus, network security is essential, and an intrusion detection system is needed. In this paper, we proposed a deep learning-based model for detecting intrusions or attacks in IoT networks. We constructed a DNN model, applied a filter method for feature reduction, and tuned the model with different parameters. We also compared the performance of DNN with other machine learning techniques in terms of accuracy, and the proposed DNN model with weight decay of 0.0001 and dropout rate of 0.01 achieved an accuracy of 0.993, and the reduced loss on the NSL-KDD dataset having five classes. DL models are a black box and hard to understand, so we explained the model predictions using LIME.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
STUDIES ON PHYTOCHEMISTRY, ANTI-CANCER PROPERTIES OF BETULA UTILIS
No full textAbstract: Betula is a versatile plant with several applications. D. Don (family Betulaceae) is a long-lived tree that has been known in Sanskrit for about 400 years as Himalayan birch, bhojpatra, or Bhurja. Its usefulness as a therapeutic plant is well acknowledged. Birch bark has recently been the topic of scientific study and industry given the presence contains triterpenoids including such betulinic acid as well as oleanolic acid, that are well for their anticancer actions. A new anticancer medication, betulinic acid promotes apoptosis in the cancer cells. Therefore, It was unique from other cancer treatments. A number of B. utilis species have been reported to contain phenolics as well as flavonoids. Suitable investigations were carried out to assess phytochemicals qualitatively using various solvents, as well as anticancer activities utilising the SRB test.
Keywords: phytochemicals, anticancer medication, cancer cells.
Title: STUDIES ON PHYTOCHEMISTRY, ANTI-CANCER PROPERTIES OF BETULA UTILIS
Author: Sandeep Singh Bhau, Dr. Arti Chaurasia
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
Vol. 10, Issue 2, April 2022 - June 2022
Page No: 22-29
Research Publish Journals
Website: www.researchpublish.com
Published Date: 06-May-2022
DOI: https://doi.org/10.5281/zenodo.6524653
Paper Download Link (Source): https://www.researchpublish.com/papers/studies-on-phytochemistry-anti-cancer-properties-of-betula-utilisInternational Journal of Interdisciplinary Research and Innovations, ISSN 2348-1218 (print), ISSN 2348-1226 (online), Vol. 10, Issue 2, April 2022 - June 2022, Research Publish Journals, Website: www.researchpublish.co
Erratum: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 (4180-4187) DOI: 10.1073/pnas.1913481117)
No full textCorrection for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler, which was first published February 7, 2020; 10.1073/pnas.1913481117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4180-4187). The authors note that Hitoshi Okada should be added to the author list between Karoline E. Kokot and David Hassel. Hitoshi Okada should be credited with providing mice. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
Some exact solitons to the (2+1)-dimensional broer-kaup-kupershmidt system with two different methods
No full textThe author, Sandeep Malik, thankfully acknowledges CSIR SRF Grant: 09/1051(0028)/2018-EMR-I.
09/1051(0028)/2018-EMR-ICSIR SRF GrantThe exact solutions of the (2 + 1) dimensional Broer-Kaup-Kupershmidt (BKK) system which has been recommended to model the nonlinear and dispersive long gravity waves traveling along with the two horizontal directions in the shallow water of uniform depth were obtained. Firstly, the given system was reduced to an ordinary differential equation (ODE) with the help of the wave transformations. Then, the reduced ODE was solved with the help of two methods which are called the modified (G'/G)-expansion method and new extended generalized Kudryashov method. We checked the results with the Maple software and plotted 3D, contour and 2D plots of some obtained solutions. As a result, we obtained exact solutions that are different from each other and have not been obtained before. Results can enhance the nonlinear dynamical behavior of a given system and demonstrate the effectiveness of the employed methodology. Results will be beneficial to a large number of engineering model specialists and useful for understanding the wave motions
Social media for improving metro rail project operations
No full textGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Integral Design & Managemen
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