70 research outputs found
Effects of ischemic phrenic nerve root ganglion injury on respiratory disturbances in subarachnoid hemorrhage: an experimental study
No full textConclusions: Phrenic nerve root ischemia may be an important factor in respiration rhythms deteriorations in SAH which has not been mentioned in the literature
Prognostic Value of TRPM7 Expression and Factor XIIIa-Expressing Tumor-Associated Macrophages in Gastric Cancer
No full textPurpose. TRPM7 is known to play a key role in tumor progression by regulating cellular proliferation, migration, and invasion in various cancer cell lines. However, there are no comprehensive clinical studies about the effect of TRPM7 expression on gastric cancer (GC) prognosis. In this study, it was aimed at investigating the effect of TRPM7 expression on prognosis in GC patients. Additionally, for the first time, it was investigated whether the density of Factor XIIIa-expressing tumor-associated macrophages (TAMs) in GC has an effect on the biological behaviour of the tumor. Methods. TRPM7 expression and Factor XIIIa-expressing TAM density were immunohistochemically evaluated in paraffin-embedded tumor tissues of 204 GC patients undergoing surgery at a single institution. Results. Tumor size was clearly higher in cases with high TRPM7 expression than those with low expression (p<0.001, Mann-Whitney U). TRPM7 overexpression was closely related to high depth of tumor invasion (p<0.001, ANOVA), increased lymph node metastasis (p<0.001, ANOVA), and high distant metastasis rate (p<0.001, Mann-Whitney U). These findings exposed that high TRPM7 expression is effective in the progression and aggressiveness of GC. In addition, while high CD8+ TIL density affects the prognosis positively, it was determined that high Factor XIIIa+ TAM density negatively affects the prognosis of patients with GC. Furthermore, multivariate analyses revealed TRPM7 overexpression was independently related with short overall (HR 9.64, 95% CI 5.74–16.19, p<0.001) and disease-free survival (HR 5.67, 95% CI 3.61-8.92, p<0.001) in GC patients. Conclusions. Our data suggest that high TRPM7 expression is closely related to progressive tumor behaviour in GC and independently negatively affects survival in patients. In addition, it was determined that a high density of Factor XIIIa+ TAMs negatively affects the prognosis of patients with GC
A Novel Interactive Fuzzy Programming Approach for Optimization of Allied Closed-Loop Supply Chains
No full textIn recent years, the relationship between companies and suppliers has changed with the continuous rise in environmental awareness and customer expectations. In order to fulfill customers' needs, the actors in a Supply Chain (SC) network sometimes compete and sometimes cooperate with each other. In SC management, both competitive and collaborative strategies have become important and have required different points of view. In a collaborative environment, companies should strive for common targets with mutual relationship. After managers decided to share their resources, some positive effects have appeared on the companies and suppliers' performance such as profitability, flexibility and efficiency. Consequently, many companies are willing to cooperate with each other in a SC network because of these reasons. On the other hand, Closed-Loop Supply Chain (CLSC) management has been attracting a growing interest because of increased environmental issues, government regulations and customer pressures. Based on this initiative, our paper presents a novel allied CLSC network design model with two different SCs including common suppliers and common collection centers. First, a decentralized multi-level Mixed-Integer Linear Programming (MILP) model that consists of two different levels of Decision Makers (DMs) is developed. The plants of common SCs comprise the upper-level DMs, common suppliers, common collection centers, and the logistics firm comprises the lower-level DMs. A novel Interactive Fuzzy Programming (IFP) approach using Fuzzy Analytic Hierarchy Process (AHP) is proposed to obtain a preferred compromise solution for the developed model. Through use of Fuzzy AHP in the proposed IFP approach, the DMs can identify the importance of the lower-level DMs. In order to validate the developed model and the proposed IFP approach, a numerical example is implemented. According to the obtained results, our proposed IFP method outperforms Sakawa and Nishizaki's(1) and Calik et al.' s(2) approach with respect to the satisfaction degrees of upper-level DMs for the developed CLSC model.Scientific and Technological Research Council of Turkey (TUBITAK) (International Postdoctoral Research Fellowship Program)In carrying out this study, the third author, Turan Paksoy, is granted by the Scientific and Technological Research Council of Turkey (TUBITAK) (International Postdoctoral Research Fellowship Program)
Covid-19 Öncesi Ve Sonrasında Amerika Birleşik Devletlerinde Bulaşıcı Hastalıkların Durumu: İş Zekası Temelli Bir Veri Analizi
No full textCOVID-19ÖNCESİ VE SONRASINDA AMERİKA BİRLEŞİK DEVLETLERİNDE BULAŞICI HASTALIKLARINDURUMU: İŞ ZEKASI TEMELLİ BİR VERİANALİZİ İremgül ZEYTİNÖZÜa,Batuhan ÇATALKAYAa, Bertuğ HASa, Doğuser YARARa,Muhammet DAMARa a Dokuz Eylül Üniversitesi, Fen Fakültesi,Bilgisayar Bilimleri, Dokuz Eylül Üniversitesi Merkez Kampüs, Buca, İzmir,Türkiye email: [email protected] ÖZETCOVID-19 pandemisi, küresel ölçekte sağlıksistemlerini sarsmakla kalmamış, aynı zamanda bulaşıcı hastalıkların yayılımı,yönetimi ve önlenmesine yönelik sağlık politikalarının yeniden şekillenmesineneden olmuştur[1,2,3]. Amerika Birleşik Devletleri (ABD), pandemiden en fazlaetkilenen ülkelerden biri olarak, hem sağlık sistemindeki yük hem de enfeksiyonhastalıklarındaki değişim açısından kritik bir vaka alanı sunmaktadır [4,5,6].Bu çalışma, COVID-19 pandemisi öncesi ve sonrasında ABD’deki bulaşıcıhastalıkların yaygınlığı, dağılımı ve eğilimlerini iş zekâsı temelli bir verianalizi yaklaşımıyla incelemeyi amaçlamaktadır. Çalışmada, 2015–2023 yıllarıarasında ABD Hastalık Kontrol ve Önleme Merkezleri, Sağlık Bakanlığı ve DünyaSağlık Örgütü gibi kurumlardan elde edilen kamuya açık veri setlerikullanılmıştır. Veriler; hastalık türleri, vaka sayıları, ölüm oranları,bölgesel dağılımlar, yaş gruplarına göre sınıflandırmalar ve sağlıkhizmetlerine erişim gibi çok boyutlu parametreler üzerindendeğerlendirilmiştir. Analiz sürecinde Power BI ve Python tabanlı veri analizaraçları kullanılarak, dinamik gösterge tabloları ve etkileşimligörselleştirmeler oluşturulmuştur. İş zekâsı uygulamaları sayesinde bölgesel vedemografik düzeyde detaylı analizler yapılabilmiş, özellikle sosyoekonomikaçıdan dezavantajlı bölgelerde bulaşıcı hastalık yükünün daha yüksek olduğutespit edilmiştir. Ayrıca COVID-19 döneminde dijital sağlık kayıtlarınınyaygınlaşması, büyük veri kaynaklarının daha etkin analizine olanak sağlamış vekarar vericilere hızlı tepki verebilme kapasitesi kazandırmıştır. Bu çerçevede,iş zekâsı araçlarının sadece epidemiyolojik izleme değil, aynı zamanda riskmodelleme, kaynak tahsisi ve erken uyarı sistemleri oluşturma açısından dabüyük bir potansiyel taşıdığı değerlendirilmiştir. Sonuç olarak bu çalışma,pandemi sürecinin bulaşıcı hastalıkların epidemiyolojik profilinde yarattığıdeğişimleri ortaya koyarken, iş zekâsı tabanlı veri analizinin halk sağlığıpolitikaları için nasıl stratejik bir araç haline geldiğini göstermektedir.Gelecekte bulaşıcı hastalıkların yönetiminde dijitalleşme, veri bilimi ve halksağlığı entegrasyonunun artırılması kritik bir gereklilik olarak öneçıkmaktadır.Anahtar Kelimeler: Tıbbi bilişim, açık veri, sağlık bilişimi, iş zekası, veri yönetimi. Kaynakça[1] Sofuoğlu, Z., Damar, H. T., Alpagut, G. S., Calik,B., Kebapci, E., Gulmez, H., ... & Damar, M. (2025). Evaluation of OlderPeople's Presentations to the Emergency Department With Pain During and Beforethe COVID-19 Pandemic. Pain Management Nursing.( Available online 14 January 2025 In Press, CorrectedProof).[2] Gölbaşı, S. D., & Metintas, S. (2020).Covid-19 pandemisi ve infodemi. ESTÜDAM Halk Sağlığı Dergisi, 5, 126-137.[3] İşlek, E., Özatkan, Y., Uslu, M. K. B.,Arı, H. O., Çelik, H., & Yıldırım, H. H. (2021). Türkiye’de COVID-19pandemisi yönetimi ve sağlık politikası stratejileri. Türkiye SağlıkEnstitüleri Başkanlığı Dergisi, 4(2), 54-65. [4] Chowell, G., & Mizumoto, K. (2020). The COVID-19 pandemic in theUSA: what might we expect?. Lancet (London, England), 395(10230), 1093.[5] Bhattacharjee, B., & Acharya, T. (2020). TheCOVID-19 pandemic and its effect on mental health in USA–a review with somecoping strategies. Psychiatric Quarterly, 91(4), 1135-1145.[6] Bergquist, S., Otten, T., & Sarich, N. (2020).COVID-19 pandemic in the United States. Health policy and technology, 9(4),623-638. </p
P2X7 receptor as an independent prognostic indicator in gastric cancer
No full textGastric cancer (GC) is one of the foremost causes of cancer-related death around the world. The P2X7 receptor (P2X7R), a member of the P2X7R subfamily of P2 receptors, is a unique molecule that has been shown to affect tumor growth and progression as well as various inflammatory processes, including proliferation of T lymphocytes, release of cytokines, and production of free oxygen radicals. P2X7R has been established as a prognostic parameter in some cancers, and recently, it has been investigated in the development of new targeted therapies. In the present study, we aimed to investigate the prognostic value of P2X7R expression in GC. The expression profile of P2X7R was evaluated immunohistochemically in 156 paraffin-embedded human GC specimens. P2X7R expression was higher in patients with lymph node metastasis than in those without (p < 0.001). P2X7R overexpression was closely related with tumor-infiltrating lymphocytes (TILs) (p = 0.001), vascular invasion (p = 0.006), depth of invasion (p < 0.001), distant metastasis (p < 0.001), and advanced tumor, node, metastasis stage (p < 0.001). Moreover, univariate (hazard ratio [HR] 3.98; 95% confidence interval (CI) 1.89-11.82; p < 0.001) and multivariate (HR 2.24; 95% CI 3.53-12.50; p < 0.001) Cox regression analysis showed that upregulated P2X7R expression clearly correlated with worsened overall survival. In summary, our data revealed that P2X7R may serve as a reliable prognostic parameter and promising therapeutic target for GC
Intratumoral Cytotoxic T-Lymphocyte Density and PD-L1 Expression Are Prognostic Biomarkers for Patients with Colorectal Cancer
No full textBackground and objectives: Cytotoxic T-lymphocyte (CTL)-mediated inflammatory response to tumors plays a crucial role in preventing the progression of some cancers. Programmed cell death ligand 1 (PD-L1), a cell-surface glycoprotein, has been reported to repress T-cell-mediated immune responses against tumors. However, the clinical significance of PD-L1 in colorectal cancer (CRC) remains unclear. Our aim was to elucidate the prognostic significance of PD-L1 expression and CD8+ CTL density in CRC. Materials and methods: CD8 and PD-L1 immunostaining was conducted on 157 pathologic specimens from patients with CRC. The CD8+ CTL density and PD-L1 expression within the tumor microenvironment were assessed by immunohistochemistry. Results: Tumor invasion (pT) was significantly correlated with intratumoral (p = 0.011) and peritumoral (p = 0.016) CD8+ CTLs density in the tumor microenvironment. In addition, there was a significant difference in the intensity of CD8+ CTLs between patients with and without distant metastases (intratumoral p = 0.007; peritumoral p = 0.037, T-test). Lymph node metastasis (pN) and TNM stage were significantly correlated with PD-L1 expression in CRC cells (p = 0.015, p = 0.029, respectively). Multivariate analysis revealed a statistically significant relationship between the intratumoral CD8+ CTL density and disease-free survival (DFS) (hazard ratio [HR] 2.06; 95% confidence interval [CI]: 1.01–4.23; p = 0.043). The DFS was considerably shorter in patients with a high expression of PD-L1 in cancer cells than those with a low expression (univariate HR 2.55; 95% CI 1.50–4.34; p = 0.001; multivariate HR 0.48; 95% CI 0.28–0.82; p = 0.007). Conversely, patients with high PD-L1 expression in tumor-infiltrating lymphocytes had a longer DFS in both univariate analysis (HR 0.25; 95% CI: 0.14–0.44; p < 0.001) and multivariate analysis (HR 3.42; 95% CI: 1.95–6.01; p < 0.001). Conclusion: The CD8+ CTL density and PD-L1 expression are prognostic biomarkers for the survival of patients with CRC
New insights of the fever following subarachnoid hemorrhage and introducing a new thermoregulator like structure in choroid plexuses; preliminary study.
No full textThe role of melatonin in preventing radiation-induced intestinal injury
No full textPurpose: Despite the therapeutic effects of radiotherapy on tumor cells, it has potential severe adverse effects on the sur- rounding normal tissues. Acute or chronic intestinal adverse effects that are likely to occur in patients undergoing radio- therapy for pelvic and abdominal cancers lead to increased morbidity, significant impairment of the quality of life, and economic losses. Various biological, chemical and pharma- cological agents are being tested to protect from and to treat radiation enteritis. This experimental study aimed to inves- tigate the protective effects of melatonin against radiation induced intestinal injury when administered before radiation exposure in rats. Methods: In the present study, villus height and the number of villi in the ileum and jejunum of rats receiving two dif- ferent doses of intraperitoneal melatonin (5 and 10 mg/kg) prior to a single fraction of radiation given at a dose of 8 Gy to the abdominal region, was evaluated by histopathological examination 3 and 7 days after radiation exposure. Results: At a dose of 5 mg/kg, melatonin was found to be effective in preventing radiation-induced injury to villus height in the jejunum and the number of villi in the ileum and jejunum, and at a dose of 10 mg/kg it was also effective in preventing radiation-induced injury to villus height in the ileum. Conclusions: Melatonin is effective for the prevention of radiation-induced intestinal injury. This outcome can be considered an evidence to test melatonin in clinical trials
Changing Trends in the Incidence of Ovarian Neoplasia and Its Relationship with the Risk Factors: A Report of 311 Cases from North-Eastern Anatolia Region
No full textObjective: Ovarian cancer is one of the most common and lethal gynecologic malignancy. In Turkey, the 8th most commonly seen neoplasm is ovarian cancer. The risk factors of ovarian cancer are menstrual reproductive events including gravida, menarche and menopause status, and life style habits such as cigarette smoking and habitat. In this study we aimed to determine the risk factors leading to ovarian cancer in Turkish women population and show the tumor markers in this population
Clinicopathological importance of Ki-67, p27, and p53 expression in gastric cancer
No full textBackground/aim: To assess the prognostic value of Ki-67, p27, and p53 immunoreactivity in human gastric cancer
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