470 research outputs found
Interview with Bashir Omar
No full textهذة المقابلة مع المؤلف بشير عمر، يتحدث عن مؤلفاتة وخاصة كتب الأطفال، كما أشار لمشكلة الكتابة المتعلقة بكتب الأطفال وكيفية حلها.أجرى المقابلة حسن شمس الدين.In this interview, author Bashir Omar (Bashir Umar) speaks about his writings. He also mentions difficulties in writing children's books and how to resolve them. The interview was conducted by Hasan Shams al-Din
Status of vitamins and minerals in children with screening‐identified celiac disease: A case‐control study
No full textObjectives: Micronutrient deficiencies characterize classical "late-diagnosed" celiac disease (CeD). This study aimed to identify the prevalence of micronutrient deficiencies among children with "early-diagnosed" screening-identified CeD to determine the clinical value of routine testing for deficiencies in those patients. Methods: A case-control study was conducted on screening-identified CeD patients diagnosed during a mass screening study (84 patients, mean age 11.3 ± 2.6 years). The controls (443 children, mean age 10.8 ± 2.5 years) were negative for celiac disease serological screening. Hemoglobin, serum levels of iron, ferritin, folate, vitamin B12, vitamin A, vitamin E, 25-OH vitamin D, zinc, and selenium were measured. Results: The mean serum levels of hemoglobin, iron, ferritin, vitamin D, zinc, copper, and selenium were significantly lower in CeD patients than in healthy controls (hemoglobin 12.56 vs. 13.02 g/dL [p = 0.04]; iron 10.61 vs. 17.6 μmol/L [p < 0.001], ferritin 25.7 vs. 48.3 μg/L [p < 0.001], vitamin D 29.1 vs. 37.5 nmol/L, zinc 11.9 vs. 21.7 μmol/L, copper 18.9 vs. 32.5 μmol/L, selenium 1.04 vs. 1.36 μmol/L; p < 0.001). Patients with celiac and severe intestinal damage (Marsh IIIb and IIIc) had significantly lower serum ferritin and vitamin A levels than patients with mild intestinal damage (Marsh II and IIIa) (ferritin 15 vs. 22 μg/L, p < 0.025; vitamin A 0.85 vs. 1.35 μmol/L, p = 0.007). Conclusion: Micronutrient deficiencies are still detectable in "early-diagnosed" screening-identified CeD cases, a clinically relevant result that strongly supports efforts for screening and early diagnosis of CeD
Performance of deamidated gliadin peptide antibodies as first screening for celiac disease in the general pediatric population
No full textBackground: Celiac serology has evolved, with the identification of newer antibodies against deamidated gliadin peptides (DGP) [e.g., anti-DGP, immunoglobulin A (IgA), and immunoglobulin G (IgG) types] with sensitivity and specificity in detecting celiac disease (CeD) that are equivalent to anti-tissue transglutaminase [anti-tissue transglutaminase (TTG) IgA]-based tests, particularly in populations with high pretest probability of CeD (prevalence of CeD > 50% of the population under study). This opens the possibility that anti-DGP assays can be used to identify CeD in the general population where the prevalence of CeD is very low (≈1%). Objective: This study aimed (1) to determine the diagnostic performance of DGP antibodies-based serologic assays in identifying CeD during the screening of the general population and (2) to compare the levels of anti-DGP antibodies among CeD patients with mild and severe degrees of enteropathy. Methods: Serology tests for DGP antibodies (DGP-IgA, DGP-IgG, and conjugate TTG/DGP antibodies) were performed on 104 serum samples of positive TTG-IgA (100 confirmed and four potential celiac patients) and a randomly selected 1,000 negative TTG-IgA serum samples collected during mass screening of children (aged 6–15 years) in 2014–2015. Results: Sera from 32 of the 1,000 TTG-IgA negative serum specimens (3.2%) tested positive for one or more of the three anti-DGP serology tests. A total of 13 of the 32 anti-DGP seropositive patients had persistent positive results on follow-up samples in 2020 (1.3%). Eight of the 13 underwent endoscopy with biopsies, and only two had confirmed CeD (both DGP-IgG positive) (0.2%). The sensitivity and specificity of the serology assays were as follows: DGP-IgA (62.7%, 40%), DGP-IgG (80.4%, 100%), and conjugate TTG/DGP (96%, 10%). Based on receiver operating characteristic curves, the area under the curve for DGP-IgG (0.919; 95% CI −0.00406 to 0.114) was comparable to TTG-IgA (0.974; 95% CI 0.924–0.995) (P = 0.0679). Titers of antibodies to DGPs were significantly higher in children with severe intestinal damage than in those in children with mild lesions (P < 0.001). Conclusion: The TTG-IgA assay remains the most reliable screening serology test for CeD in mass screening studies. The performance of TTG-IgA has improved marginally by adding DGP-IgG to the mass screening protocol. In CeD patients detected by mass screening, the anti-DGP antibody titer was significantly higher among patients with a severe degree of enteropathy as compared to the group with mild enteropathy
Interview with Abd al-Razzaq al-Bashir
No full textهذة المقابلة مع عبد الرزاق البصير الكاتب الكويتي ، وعضو في مجمع اللغة العربية في القاهرة ، يتحدث عن نشأتة وتعليمه. يشير للشعراء المفضلين له، الذين أثروا في شخصيته. ويشير إلى أهمية اللغة العربية في حياته. أجرى المقابلة حسن شمس الدين.In this interview, Kuwaiti author Abd al-Razzaq al-Bashir speaks about his early life and education. He mentions his favorite poets that impacted his life and the importance of the Arabic language. The interview was conducted by Hasan Shams al-Din
First person – Aushaq Bashir Malla
No full textABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Aushaq Bashir Malla is co-first author on ‘ IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids’, published in Journal of Cell Science. Aushaq is a PhD student at the Centre for DNA Fingerprinting and Diagnostics, India, investigating the post-transcriptional regulation of mRNA and role of RNA–protein interactions in disease and development.</jats:p
Application of Analog Adaptive Filters for Dynamic Sensor Compensation
No full textThis paper investigates the application of analog adaptive techniques to the area of dynamic sensor compensation, of which there is little reported work in the literature. The case is illustrated by showing how the response of a load cell can be improved to speed up the process of measurement. The load cell is a sensor with an oscillatory output in which the measurand contributes to the response parameters. Thus, a compensation filter needs to track variation in measurand whereas a simple, fixed filter is only valid at one specific load value. To facilitate this investigation, computer models for the load cell and the adaptive compensation filter have been developed. To allow a practical implementation of the adaptive techniques, a novel piecewise linearization technique is proposed in order to vary a floating voltage-controlled resistor in a linear manner over a wide range. Simulation and practical results are presented, thus demonstrating the effectiveness of the proposed techniques
A Fast and Accurate Process Variation-aware Modeling Technique for Resistive Bridge Defects
No full textRecent research has shown that tests generated without taking process variation into account may lead to loss of test quality. At present there is no efficient device-level modeling technique that models the effect of process variation on resistive bridge defects. This paper presents a fast and accurate technique to achieve this, including modeling the effect of voltage and temperature variation using BSIM4 transistor model. To speedup the computation time and without compromising simulation accuracy (achieved through BSIM4) two efficient voltage approximation algorithms are proposed for calculating logic threshold of driven gates and voltages on bridged lines of a fault-site to calculate bridge critical resistance. Experiments are conducted on a 65-nm gate library (for illustration purposes), and results show that on average the proposed modeling technique is more than 53 times faster and in the worst case, error in bridge critical resistance is 2.64% when compared with HSPICE
Replication Data for: Testing Inferences about American Politics: A Review of the "Oligarchy" Result
No full textDataset attached to the original Gilens and Page article (renamed gp_data.dta) and two original-author files that describe it (gp_variables_seeDS1.pdf, gp_codings.pdf). Additionally, five .R files that replicate different parts of the response to the original article. Footnotes in the response paper describe each of the .R files
Replication Data for: Testing Inferences about American Politics: A Review of the "Oligarchy" Result
No full textDataset attached to the original Gilens and Page article (renamed gp_data.dta) and two original-author files that describe it (gp_variables_seeDS1.pdf, gp_codings.pdf). Additionally, five .R files that replicate different parts of the response to the original article. Footnotes in the response paper describe each of the .R files
Low-energy standby-sparing for hard real-time systems
No full textTime-redundancy techniques are commonly used in real-time systems to achieve fault tolerance without incurring high energy overhead. However, reliability requirements of hard real-time systems that are used in safety-critical applications are so stringent that time-redundancy techniques are sometimes unable to achieve them. Standby sparing as a hardware redundancy technique can be used to meet high reliability requirements of safety-critical applications. However, conventional standby-sparing techniques are not suitable for low-energy hard real-time systems as they either impose considerable energy overheads or are not proper for hard timing constraints. In this paper we provide a technique to use standby sparing for hard real-time systems with limited energy budgets. The principal contribution of this work is an online energy management technique which is specifically developed for standby-sparing systems that are used in hard real-time applications. This technique operates at runtime and exploits dynamic slacks to reduce the energy consumption while guaranteeing hard deadlines. We compared the low-energy standby-sparing (LESS) system with a low-energy time redundancy system (from a previous work). The results show that for relaxed time constraints, the LESS system is more reliable and provides about 26% energy saving as compared to the time-redundancy system. For tight deadlines when the time redundancy system is not sufficiently reliable (for safety-critical application), the LESS system preserves its reliability but with about 49% more energy consumptio
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