31 research outputs found
فکر اقبال کی ترویج واشاعت میں ڈاکٹراسلم انصاری کا حصہ
No full textDr. Muhammad Aslam Ansari was born on 30 April 1939, in Multan, Pakistan. He has published more than 20 books. He is prominent researcher and a good critic of Urdu literature. His Four books have been published on the subject of Iqbaliyat; i.e. Iqbal Ehad Afreen, Shair o Fikar-E Iqbal, Faizan e Iqbal, Iqbal Ehad Saaz Shaiyar Aur Mufakkir. His research work on Iqbaliyat gives him notable position among the specialists of Iqbal studies. He has also pen down different essays about the various prospects of Iqbal's poetry. Allama Iqbal holds a prominent status in Urdu poetry and literature. Even today the poetry of Iqbal is an enlightment example for the Muslim youth. Iqbal is from one of those distinct examples of historical, philosophical and literary figures whose poetic and philosophical concepts were commended at national and international levels. Transcripts of Iqbal have at least been translated into 26 languages so far a well transcribed library of his thoughts. Iqbal's personality is unique in term of themes but in this field of Iqbal Shinasi.This article presents a detailed analysis of Dr. Aslam Ansari's research on Iqbal.
Preparation and characterization of hybrid pH-sensitive hydrogels of chitosan-co-acrylic acid for controlled release of verapamil
No full textPhysicochemical characterization of artemether solid dispersions with hydrophilic carriers by freeze dried and melt methods
No full textThe Phytochemical and Comparative Anticancer Study of Methanolic and Chloroform Extracts of Psidium guajava L. Leaves of Pakistani Origin
No full textThe chief focus of our study is to evaluate the phytochemical and anti-cancer activity of methanol (PGM) and chloroform extracts (PGC) of the leaves of Psidium guajava (guava) collected from local area of district Sialkot, Pakistan. Shade dried milled leaves was subjected to extraction (maceration) with methanol and chloroform. Quantitative and qualitative screenings by GC-MS and phytochemical techniques were performed. Then different secondary metabolites and phytochemical compounds were identified which are typically associated with the existence of therapeutic characteristics. Psidium guajava has been extensively used as herbal remedies like, anti-diarrheal, antihypertensive, antibacterial, antifungal as well as to control obesity, ulcer, diabetes. In this study, both extracts of P. guajava were evaluated for their anticancer activities against HeLa cell-lines (cancerous cells). The healthiest anticancer response in the form of cell-line suppression was perceived with 200µg/mL of both extracts, PGM showed 81% and PGC exhibited 91% while the standard drug doxorubicin presented around 76% inhibition. The comparative better result was seen with chloroform extract than methanolic abstract. In conclusion, the chloroform and methanol extracts of our nominated plant from Pakistan origin has a good source of phytochemicals that revealed an outstanding anti-cancer potential.
Keywords: Psidium guajava, anticancer, phytochemicals, methanol extracts, secondary metabolites
Design and development of muscle monitoring system to visualize and monitor the activity of Bicep Brachii with varying load
No full textImprovement of solubility, dissolution and stability profile of artemether solid dispersions and self emulsified solid dispersions by solvent evaporation method
No full textThe purpose of this study was to investigate changes in the water solubility of artemether; a poorly soluble drug used for the treatment of malaria. Different solid dispersions (SDs) of artemether were prepared using artemether and polyethylene glycol 6000 at ratio 12:88 (Group 1), self-emulsified solid dispersions (SESDs) containing artemether, polyethylene glycol 6000, cremophor-A-25, olive oil, hydroxypropylmethylcellulose and transcutol in the ratio 12:75:5:4:2:2, respectively (Group 2). SESDs were also prepared by substituting cremophor-A-25 in Group 2 with poloxamer 188 (noted as Group 3). Each of these preparations was formulated using physical mixing and the solvent evaporation method. Aqueous solubility of artemether improved 11-, 95- and 102-fold, while dissolution (in simulated gastric fluid) increased 3-, 13- and 14-fold, for formulation groups 1, 2 and 3, respectively. X-ray diffraction patterns of SDs indicated a decrease in peak intensities at 10° implying reduced artemether crystallinity. Scanning electron micrographs invariably revealed embedment of artemether by various excipients and a glassy appearance for solvent evaporated mixtures for all three formulation Groups. Our findings indicate improved hydrophilic interactions for drug particles yield greater solubility and dissolution in the following order for artemether formulating methods: solvent evaporation mixtures > physical mixtures > pure artemether.</p
Vildagliptin loaded triangular DNA nanospheres coated with eudragit for oral delivery and better glycemic control in type 2 diabetes mellitus
No full textDiabetes mellitus type 2 is a multidimensional disease associated with poor glycemic control through compromised sensitivity of pancreatic islet α and β cells against glucose and dwindled secretion of insulin which is linked with the quantity of incretin hormones that are abridged by dipeptidyl peptidase-4 (DPP-4) in diseased condition. Vildagliptin (VG) inhibits DPP-4 therefore regulates the incretins that conversely maintains glycemic control. The safe reach and absorption of VG from intestine was dubious. Therefore we used Electrostatic Attraction Method to develop drug loaded DNA nanotechnology triangles coated by Eudragit (Eud) to make stable nanospheres of Vildagliptin (VG). We further analyzed the formulated nanospheres by AFM, XRD, DSC, SEM, TGA, ATR-FTIR and native PAGE. Additionally the efficacy of formulated nanospheres for drug release and glycemic control was assessed in Db/Db mouse. Our results showed that formulated nanospheres are smooth, spherical, stable and uniform in size ranging from 500 to 2000 nm with drug entrapment efficiency up to 95 ± 2% and extended drug release up to 15 ± 2 h. FTIR and DSC results confirmed the absence of VG-DNA-Eud interaction and XRD studies revealed a change in the crystalline status of the VG in nanospheres. Ex-vivo studies indicate that Eud-DNA-VG nanospheres effectively bypasses the acidic pH of the stomach and enhances glycemic control in Db/Db mouse without any risk of pancreatitis or pancreatic cancer. To the best of our knowledge, this is the first study conclusively reporting that VG loaded DNA Nano-architects coated with Eudragit are stable, safe and may improve therapeutic outcomes after oral delivery.</p
Improving the Solubility and Bioavailability of Dihydroartemisinin by Solid Dispersions and Inclusion Complexes
No full textDihydroartemisinin (DHA) is a poorly water-soluble drug that displays low bioavailability after oral administration. Attempts have been made to improve the solubility of DHA. Yet, no information is available concerning improved bioavailability. This study aimed to improve the water solubility of DHA by two systems: solid dispersions with polyvinylpyrrolidone (PVPK30, PVPK25, PVPK15) and inclusion complexes with hydroxypropyl-β-cyclodextrin (HPβCD), as well as improving the bioavailability of both systems. The phase transition of DHA with hydrophilic polymers was evaluated by X-ray diffraction (XRD) and differential scanning calorimetery (DSC). DHA became amorphous in DHA-HPβCD complexes and showed more amorphous behavior in XRD analyses with rise in molecular weight of PVP. Melting onset temperature of DHA decreased, while DSC thermograms revealed the peak area and enhanced enthalpy change (DH) in solid dispersions as well as inclusion complexes. DHA solubility was enhanced 84-fold in DHA-HPβCD complexes and 50-times in DHA-PVPK30. The improved solubility using the four polymers was in the following order: HPβCD > PVPK30 > PVPK25 > PVPK15. Values of area under curve (AUC) and half life (t(1/2)) of DHA-PVPK30 were highest followed by DHA-HPβCD, DHA-PVPK15 and DHA-PVPK25. V(d)/f of DHA-PVPK30 was 7-fold. DHA-HPβCD, DHA-PVPK15 and DHA-PVPK25 showed significantly different pharmacokinetic parameters compared with DHA solutions. The 95% confidence interval was meaningful in AUC and t(1/2). Pharmacokinetic parameters revealed that all four-test preparations were significantly more bioavailable than DHA alone
Groundwater budgeting of Nari and Gaj formations and groundwater mapping of Karachi, Pakistan
No full textGroundwater depletion is an emerging problem worldwide due to changes in climate and an increase in urbanization. Two significant water-bearing formations, the Oligocene-aged Nari and the Miocene-aged Gaj, were utilized as a case study exposed near Karachi, Pakistan. Groundwater budgeting was performed through a classical equation. The inflow of groundwater in the formations was calculated by thermo-pluviometric data and water loss of Hub Dam. The potential of evapotranspiration (PET) was calculated by the Thornthwaite method. The groundwater inflow from Hub Dam was estimated by using 20 years of annual water loss data by removing PET. The total mean annual inflow of groundwater in the formations was 2414.12 US Gallons per Second (gps). The annual mean outflow was estimated by calculation of groundwater usage for industries and domestic purposes and the mean annual groundwater outflow was 5562.61 US gps and an annual deficit of groundwater was 3148.5 US gps. The research is composed of validating the groundwater budget. Direct Current Electrical Resistivity (DCER) and static water level data from existing industrial wells were used for groundwater maps. The DCER data indicates A-Type and K-Type sub-surface with high resistivity in the three-layer model. The average water table of residential areas in 2019 was 60 m and in industrial areas was 130 m. The oscillation of the groundwater table over the last 20 years and the deficit of the groundwater budget shows an alarming condition for the future. If the same scenario persists, then by 2025, the water table will decline up to 140 m.Validerad;2022;Nivå 2;2022-11-03 (sofila)</p
