75 research outputs found
Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation
No full textPreventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia
No full textBACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including obesity, hypercholesterolemia and diabetes. In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi-Men) against lifestyle related disorders.
METHODS: Functional drinks (T2 and T3) were prepared by adding catechins and epigallocatechin gallate (EGCG) @ 550mg/500mL and compared with control (T1). These functional drinks were tested in experimental rats modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high cholesterol diet), trial-III (high sucrose diet), trial-IV (high cholesterol+high sucrose diet). Rats were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56days rats were sacrificed and evaluated their serum lipid (cholesterol, LDL and HDL), glucose and insulin levels.
RESULTS: Results for feed consumption by rats revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, cholesterol and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum glucose and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing EGCG reduced the trait better than catechins based functional drink.
CONCLUSIONS: The drinks supplemented with catechins and EGCG are effective against obesity, hypercholesterolemia and hyperglycemia
Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus
No full textBackground: Nigella sativa fixed (NSFO) and essential (NSEO) oils have been used to treat diabetes mellitus and its
complications. Present study was undertaken to explore and validate these folkloric uses.
Methods: Sprague dawley rats having streptozotocin (STZ) induced diabetes mellitus were used to assess the role
of NSFO and NSEO in the management of diabetes complications. Parameters investigated were antioxidant
potential, oxidative stress, and the immunity by in vivo experiments.
Results: The results indicated that STZ decreased the glutathione contents (25.72%), while NSFO and NSEO
increased the trait significantly (P < 0.05). Experimental diets increased the tocopherol contents (P < 0.01) and
enhanced the expression of hepatic enzymes (P < 0.01). Correlation matrix further indicated that antioxidant
potential is positively associated (P < 0.05) responsible for the modulation of hepatic enzymes and the decrease of
the nitric oxide production thus controlling the diabetes complications.
Conclusions: Overall, results of present study supported the traditional use of N. sativa and its derived products as
a treatment for hyperglycemia and allied abnormalities. Moreover, N. sativa fixed and essential oils significantly
ameliorate free radicals and improve antioxidant capacity thus reducing the risk of diabetic complications
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