1,721,283 research outputs found
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Čɪtraalaz tilɪṇa kisa
No full textIn this conversation with Atta-Ur Rehman, Muhammad Suleman recounts the personal experiences of his first ever journey to the Chitral district of the Khyber-Pakhtunkhwa province where he attended a workshop on orthography and conservation of regional languages of Pakistan organized by the Project Director, Dr. Sadaf Munshi, in collaboration with the Forum for Language Initiatives, Islamabad (Pakistan)
Recommended from our members
Čɪtraalaz tilɪṇa kisa
No full textIn this conversation with Atta-Ur Rehman, Muhammad Suleman recounts the personal experiences of his first ever journey to the Chitral district of the Khyber-Pakhtunkhwa province where he attended a workshop on orthography and conservation of regional languages of Pakistan organized by the Project Director, Dr. Sadaf Munshi, in collaboration with the Forum for Language Initiatives, Islamabad (Pakistan)
Recommended from our members
čɪtraalaz tilɪṇa kisa (2)
No full textIn this conversation with Atta-Ur Rehman, Muhammad Suleman recounts the personal experiences of his first-ever journey to Chitral District where he attended a workshop on orthography and conservation of regional languages of Pakistan, organized by the Project Director, Dr. Sadaf Munshi, in collaboration with the Forum for Language Initiatives, Islamabad (Pakistan)
Recommended from our members
čɪtraalaz tilɪṇa kisa (2)
No full textIn this conversation with Atta-Ur Rehman, Muhammad Suleman recounts the personal experiences of his first-ever journey to Chitral District where he attended a workshop on orthography and conservation of regional languages of Pakistan, organized by the Project Director, Dr. Sadaf Munshi, in collaboration with the Forum for Language Initiatives, Islamabad (Pakistan)
Human Surfactant Protein D Suppresses Epithelial-to-Mesenchymal Transition in Pancreatic Cancer Cells by Downregulating TGF-β
Full text linkHuman surfactant protein-D (SP-D), an innate immune pattern recognition soluble factor, is known to modulate a range of cytokines and chemokines, such as TNF-α and TGF-β at mucosal surfaces during infection, allergy, and inflammation. A recent study has shown that treatment with a recombinant fragment of human SP-D (rfhSP-D) for 48 h induces apoptosis in pancreatic cancer cells. Our hypothesis is that at earlier time points, SP-D can also influence key cytokines as a part of its putative role in the immune surveillance against pancreatic cancer, where the inflammatory tumor microenvironment contributes to the epithelial-to-mesenchymal transition (EMT), invasion, and metastasis. Here, we provide the first evidence that rfhSP-D can suppress the invasive-mesenchymal properties of highly aggressive pancreatic cancer cells. Mechanistically, rfhSP-D inhibited TGF-β expression in a range of pancreatic cancer cell lines, Panc-1, MiaPaCa-2, and Capan-2, thereby reducing their invasive potential. Smad2/3 expression diminished in the cytoplasm of rfhSP-D-treated cells as compared to the untreated control, suggesting that an interrupted signal transduction negatively affected the transcription of key mesenchymal genes. Thus, expressions of Vimentin, Zeb1, and Snail were found to be downregulated upon rfhSP-D treatment in the pancreatic cancer cell lines. Furthermore, blocking TGF-β with neutralizing antibody showed similar downregulation of mesenchymal markers as seen with rfhSP-D treatment. This study highlights yet another novel innate immune surveillance role of SP-D where it interferes with EMT induction by attenuating TGF-β pathway in pancreatic cancer
Supplemental Material, DS1_VET_10.1177_0300985818765067 - Histologic Changes Associated With Placental Separation in Gilts Infected with Porcine Reproductive and Respiratory Syndrome Virus
No full textSupplemental Material, DS1_VET_10.1177_0300985818765067 for Histologic Changes Associated With Placental Separation in Gilts Infected with Porcine Reproductive and Respiratory Syndrome Virus by Predrag Novakovic, Susan E. Detmer, Muhammad Suleman, Carol M. Malgarin, Daniel J. MacPhee, and John C.S. Harding in Veterinary Pathology</p
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niiraṇa ha baaleeṇa kisa
No full textTranscription and translation of a retelling of the story about sleep and air as narrated by Muhammad Suleman
Recommended from our members
niiraṇa ha baaleeṇa kisa
No full textTime-aligned translation and transcription of a retelling of the story about sleep and air as narrated by Muhammad Suleman
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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