33 research outputs found
Case-Control Study of Corneal Endothelial Cell Density in Primary Open-Angle Glaucoma Patients Versus Normal Population Using Specular Microscopy in Rawalpindi, Pakistan
No full textObjective: To assess Endothelial cell counts in the corneas of patients with primary open-angle glaucoma
(POAG) as compared to age-matched healthy individuals using Corneal Specular Microscopy.
Study Design: Case-control study.
Place and Duration of Study: This study was conducted at the Armed Forces Institute of Ophthalmology (AFIO),
Rawalpindi, Pakistan from December 2023 to May 2024.
Methods: A total of 50 individuals were recruited, including 25 phakic Primary Open Angle Glaucoma patients
on antiglaucoma medications for at least five consecutive years. They were compared with 25 healthy phakic
individuals as controls. All the individuals were aged 50-60 years. Intraocular pressure (IOP) was recorded using
Goldmann Applanation Tonometry (GAT). Endothelial cell density was measured using Indirect Specular
Microscopy SP-3000P® in both groups after thorough ophthalmological examination. SPSS 25 was used for
statistical analysis. Age was stratified into 3-year intervals from 50 to 60 years. Paired sample t-test was
employed to assess the mean difference, and a P-value <0.05 was considered statistically significant.
Results: Among included participants ( N=50), 26 (52%) were males and 24 (48%) were females. Participants
had a mean age of 55.08 ± 2.48 years. The mean endothelial cell count in Primary Open Angle Glaucoma
patients was 2067±155 cells/mm² compared to controls 2715±315 cells/mm² (P=0.0001). There was no
statistically significant difference in endothelial cell counts (in cells/mm²) between males and females or across
stratified age groups. (P > 0.05)
Conclusion: Primary Open Angle Glaucoma patients exhibit significantly reduced endothelial cell density
compared to healthy individuals. Chronic intraocular pressure elevation and long-term exposure to antiglaucoma medications may contribute to endothelial loss of cells.
How to cite this: Sajjad S, Rauf A, Haider MK, Zahra SM, Naseer MS, Zahra F. Case-Control Study of Corneal Endothelial Cell Density in Primary Open-Angle Glaucoma Patients Versus Normal Population Using Specular Microscopy in Rawalpindi, Pakistan. Life and Science. 2025; 6(3): 381-386. doi: http://doi.org/10.37185/LnS.1.1.88
Medical negligence in healthcare organizations and impacts on the patient safety: A bibliometric study
No full textThe current study aimed to analyze various components of medical negligence research literature. Bibliographic data visualizations tools like Biblioshiny (RStudio), VOSviewer, and Histcite were used besides MS Excel to examine the types of documents, annual scientific production, top contributing authors and their impact, authorship patterns and collaboration, top contributing countries and organizations, most significant sources of publication, most cited documents, and most frequently used keywords. Bibliometric methods were used to analyze these aspects of medical negligence research literature. The bibliographic records of research output on medical negligence research were downloaded from the Web of Science Core Collection. The results of the study showed that the annual productivity of medical negligence research was increasing gradually with the passage of time. It showed that the most productive period for medical negligence research was 2011-2020 with about half of the total research output. Bird contributed the highest number of publications to medical negligence literature while Brennan emerged as the highly cited author. Results of the study revealed that single-authored publications on medical negligence were not highly cited. The United States was the highest contributing country and the University of South Florida was the highest contributing organization while Harvard University was a highly cited organization. The analysis discovered that nine out of the top ten contributing organizations were academic institutions and most of them belonged to the United States. The most important sources of publication for medical negligence research were The Lancet and British Medical Journal. The study revealed that the research paper by Localio et al. was the most important research article on medical negligence research. The study concluded that research on medical negligence was getting the attention of the researchers, which resulted in a sharp increase in the research output during the last two decades
Medical negligence in healthcare organizations and impacts on the patient safety: A bibliometric study
No full textBackground: Medical negligence is an increasing public health concern among health care providers worldwide. It poses a significant risk of patient injury, disease, disability, or death. The current study aimed to analyze various components of medical negligence research literature.
Methods: bibliographic data visualizations tools like Biblioshiny (RStudio) and VOSviewer were used besides MS Excel to examine the types of documents, annual scientific production, top contributing authors and their impact, authorship patterns and collaboration, top contributing countries and organizations, most significant sources of publication, most cited documents, and most frequently used keywords. Bibliometric methods were used to analyze the bibliographic records of research output on medical negligence downloaded from the Web of Science Core Collection.
Results: the results of the study showed that the annual productivity of medical negligence research was increasing gradually. It showed that the most productive period for medical negligence research was 2011-2020. Bird contributed the highest number of publications to medical negligence literature while Brennan emerged as the highly cited author. Results revealed that single-authored publications on medical negligence were not highly cited. The United States was the highest contributing country and the University of South Florida was the highest contributing organization while Harvard University was a highly cited organization. The analysis discovered that nine out of the top ten contributing organizations were academic institutions and most of them belonged to the United States. The most important sources of publication for medical negligence research were The Lancet and British Medical Journal. The study revealed that the research paper by Localio et al. was the most important research article on medical negligence research.
Conclusion: the study concluded that research on medical negligence was getting the attention of the researchers, which resulted in a sharp increase in the research output during the last two decades
Medical negligence
No full textBackground: Medical negligence is an increasing public health concern among health care providers worldwide. It poses a significant risk of patient injury, disease, disability, or death. The current study aimed to analyze various components of medical negligence research literature.
Methods: bibliographic data visualizations tools like Biblioshiny (RStudio) and VOSviewer were used besides MS Excel to examine the types of documents, annual scientific production, top contributing authors and their impact, authorship patterns and collaboration, top contributing countries and organizations, most significant sources of publication, most cited documents, and most frequently used keywords. Bibliometric methods were used to analyze the bibliographic records of research output on medical negligence downloaded from the Web of Science Core Collection.
Results: the results of the study showed that the annual productivity of medical negligence research was increasing gradually. It showed that the most productive period for medical negligence research was 2011-2020. Bird contributed the highest number of publications to medical negligence literature while Brennan emerged as the highly cited author. Results revealed that single-authored publications on medical negligence were not highly cited. The United States was the highest contributing country and the University of South Florida was the highest contributing organization while Harvard University was a highly cited organization. The analysis discovered that nine out of the top ten contributing organizations were academic institutions and most of them belonged to the United States. The most important sources of publication for medical negligence research were The Lancet and British Medical Journal. The study revealed that the research paper by Localio et al. was the most important research article on medical negligence research.
Conclusion: the study concluded that research on medical negligence was getting the attention of the researchers, which resulted in a sharp increase in the research output during the last two decades
Medical negligence in healthcare organizations and its impact on patient safety and public health: a bibliometric study [version 1; peer review: 2 approved]
No full textBackground: Medical negligence is an increasing public health concern among healthcare providers worldwide as it affects patient safety. It poses a significant risk of patient injury, disease, disability, or death. The WHO has recognized deficiencies in patient safety as a global healthcare issue to be addressed. This study aimed to analyze various components of medical negligence research literature. Methods: Bibliographic data visualizations tools like Biblioshiny (RStudio) and VOSviewer were used besides MS Excel to examine the types of documents, annual scientific production, top contributing authors and their impact, authorship patterns and collaboration, top contributing countries and organizations, most significant sources of publication, most cited documents, and most frequently used keywords. Bibliometric methods were used to analyze the bibliographic records of research output on medical negligence downloaded from the Web of Science Core Collection. Results: The annual productivity of medical negligence research was increasing gradually. The most productive period for medical negligence research was 2011-2020. Bird contributed the highest number of publications to medical negligence literature while Brennan emerged as the highly cited author. Single-authored publications on medical negligence were not highly cited. The United States was the highest contributing country and the University of South Florida was the highest contributing organization while Harvard University was a highly cited organization. Nine out of the top ten contributing organizations were academic institutions and most of them belonged to the United States. The most important sources of publication on this topic were The Lancet and British Medical Journal. Localio et al. was the most important research article on medical negligence research. Conclusion: Due to increasing attention on this topic, there was a sharp increase in the research output on medical negligence. This is of significance as the WHO set in motion a patient safety program almost two decades ago
Pakistan cotton survey 2014, round 1.3
No full textThe dataset "Pakistan Cotton Survey 2014, Round 1.3" was collected to inform the research study that examines the efficiency of markets for cotton seed in Pakistan with particular emphasis on the market for genetically modified cotton seed embodying insect-resistance traits from the soil bacterium Bacillus thurigiensis (Bt) that have been conferred through genetic modification.
The survey was designed by the International Food Policy Research Institute (IFPRI) and implemented by Innovative Development Studies (IDS). It collected data on the harvest from each picking and the total sales of cotton. Round 1.3 was implemented between January-February in 2014, immediately after the last harvest. Data were collected from the households sampled in Round 1.1. Of the original sample of 728 households, 46 chose not to grow cotton in kharif 2013, 70 lost their crops to flood or other natural disasters, four migrated and eight dropped out in the second- or third-round surveys.PSSP; IFPRI1EPTD; PIMCGIAR Research Program on Policies, Institutions, and Markets (PIM
Interpretable machine learning approaches to assess the compressive strength of metakaolin blended sustainable cement mortar
No full textAbstract The use of naturally available materials such as metakaolin (MK) can greatly reduce the utilization of emission intensive materials like cement in the construction sector. This would reduce the stress on depleting natural resources and foster a sustainable construction industry. However, the laboratory determination of 28 day compressive strength (C-S) of MK-based mortar is associated with several time and resource constraints. Thus, this study was conducted to develop reliable empirical prediction models to assess CS of MK-based mortar from its mixture proportion using machine learning algorithms like gene expression programming (GEP), extreme gradient boosting (XGB), multi expression programming (MEP), bagging regressor (BR), and AdaBoost etc. A comprehensive dataset compiled from published literature having five input parameters including water-to-binder ratio, mortar age, and maximum aggregate diameter etc. was used for this purpose. The developed models were validated by means of error metrics, residual assessment, and external validation checks which revealed that XGB is the most accurate algorithm having testing of 0.998 followed by BR having values equal to 0.946 while MEP had the lowest testing of 0.893. However, MEP and GEP algorithms expressed their output in the form of empirical equations which other black-box algorithms couldn’t produce. Moreover, interpretable machine learning approaches including shapely additive explanatory analysis (SHAP), individual conditional expectation (ICE), and partial dependence plots (PDP) were conducted on the XGB model which highlighted that water-to-binder ratio and sample age are some of the most significant variables to predict the C-S of MK-based cement mortars. Finally, a graphical user interface (GUI) was made for implementation of findings of this study in the civil engineering industry
Citizenship and political participation in the State of Kuwait : the case of National Assembly (1963-1996)
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Successful Simultaneous Pancreas and Kidney Transplant in a Patient Post-COVID-19 Infection
No full text
