62 research outputs found
Molecular Docking Simulation Data on Phytocompounds from Methanol Extract of Muntingia calabura
No full textAntioxidant and anti-inflammation properties of Mutingia calabura extracts have been reported by multiple studies, suggesting its potential in treating type 2 diabetes mellitus (T2DM). Inhibition of α-glucosidase has been used as a management of T2DM, where many efforts have been made to find more effective drugs with less side effect. Herein, the research aimed to unveil the potential of phytoconstituents contained in methanol extract of Mutingia calabura leaves in inhibiting α-glucosidase through molecular docking simulation. Firstly, the data of the identified phytocompounds were acquired from a systematic search in Scopus database. The molecular docking was than performed to observe the interaction of the phytocompound with the active sites of human α-glucosidase. We found that fisetin, pinostrobin, and rhamnetin were phytoconstituents with molecular weight of less than 500 g/mol and the highest binding affinity (-7.5, -7.6, and -7.5 kcal/mol, respectively). Based on the residue it forms the interaction with, fisetin was revealed as the most potential α-glucosidase inhibitor candidate. Further in-vitro or in-vivo studies are required to elucidate the role of fisetin along with other M. calabura-derived phytocompounds in T2DM treatment
SINTESIS BUSA POLIURETAN TERMODIFIKASI KITOSAN UNTUK ADSORPSI LOGAM MERKURI
No full textSintesis busa poliuretan termodifikasi kitosan (Chi-PUF) telah dilakukan dan diaplikasikan untuk mengadsorpsi logam merkuri dalam air. Sintesis busa poliuretan memanfaatkan minyak jarak sebagai poliol karena sifatnya yang biodegradable dan harganya yang murah. Untuk meningkatkan sifat fisik busa poliuretan, gliserol ditambahkan dalam bahan poliol sebanyak 20 %. Chi-PUF disintesis dengan variasi komposisi campuran A (minyak jarak dan gliserol), toluen diisosianat (TDI), akuades dan kitosan dengan variasi suhu pre-heating. Sifat fisik dan morfologi Chi-PUF diuji menggunakan spektroskopi fourier transform infra-red FT-IR, scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) dan differential scanning calorimetry (DSC). Komposisi campuran A : TDI : akuades optimum yang diperoleh adalah 1 : 0,5 : 0,5. Hasil uji adsorpsi pada kondisi optimum ditunjukkan oleh uji adsorpsi pada pH 7 dengan waktu kontak 60 menit. Adsorpsi ion logam Hg (II) oleh Chi-PUF mengikuti model isoterm Fruendlih (R2 = 0,9417). Uji adsorpsi pada tiga sampel air sumur yang mengandung merkuri menunjukkan persen removal tersebar sebanyak 83,049%
ANALISIS LOGAM BERAT DALAM AIR MELALUI KONVERSI LIQUID-SOLID DENGAN ADSORBEN FILM POLIMER MENGGUNAKAN TEKNIK LASER-INDUCED BREAKDOWN SPECTROSCOPY
No full textANALISIS TIMBAL (II) DALAM AIR MENGGUNAKAN TEKNIK LIBS DENGAN BANTUAN ADSORBEN POLIURETAN-SELULOSA ASETAT
No full textTeknik Laser-Induced Breakdown Spectroscopy (LIBS) tengah marak dikembangkan aplikasinya untuk dapat menganalisis polutan logam berat dalam air. Ini dikarenakan kelebihan yang dimiliki teknik LIBS, seperti proses yang cepat, cara pengoperasian yang mudah, dan tidak memerlukan pre-treatment yang rumit. Namun demikian, ketika laser ditembakkan ke permukaan cairan, plasma yang dihasilkan cenderung kecil dan adanya percikan air yang membuat signal yang terbaca menjadi tidak stabil. Untuk itu, ion logam yang terlarut dalam air terlebih dahulu dikonversi menjadi bentuk solid melalui adsorpsi. Membran poliuretan-selulosa asetat dapat digunakan sebagai adsorben terhadap berbagai macam ion logam, yang mana pada penelitian ini menggunakan Pb2+ sebagai model ion logam berat. Membran poliuretan-selulosa asetat telah dikarakterisasi menggunakan spektroskopi inframerah dan Scanning Electron Microscopy (SEM), menunjukkan adanya modifikasi secara kimia dan morfologi permukaan. Selain itu, penambahan rantai poliuretan pada selulosa asetat juga mempengaruhi sifat fisik dan termalnya. Dalam analisis LIBS, delay time dan energi optimum yang digunakan masing-masing adalah 3000 ns dan 54 mJ. Pengaruh waktu kontak, pH dan konsentrasi awal pada adsorpsi Pb2+ telah diamati dengan teknik LIBS. Kurva kalibrasi yang dihasilkan pada penelitian ini memiliki bentuk kuadratik dengan persamaan y = 0.0036x2 - 0.0035x + 2.4386 dan R2 = 0,996. LOD yang didapatkan relatif lebih rendah dibandingkan dengan penelitian-penelitian sebelumnya. Dengan demikian dapat disimpulkan bahwa membran PUSA dapat diaplikasikan pada analisis kualitatif dan kuantitatif Pb2+ dalam air menggunakan teknik LIBS, dengan keunggulan metode yang lebih praktis dan dapat digunakan secara in-situ
PRISMA Checlist for "Website-based handwashing intervention to prevent COVID-19 and other infectious diseases: Is it ideal? – A systematic review and meta-analysis"
No full textThis contains PRISMA checklist for a systematic analysis and meta-analysis.</p
PRISMA Checklist for anti-SARS-CoV-2 molecular targets of essential oil
No full textThis is a PRISMA checklist for a systematic review </p
Bibliometric Analysis and ChatGPT-Assisted Identification of Key Strategies for Improving Primary Maternity Care Based on a Decade of Collective Research
No full textSidik Maulana,1,* Muhammad Iqhrammullah,2,* Rovy Pratama,3 Sydney Tjandra,4 Intan Chaharunia Mulya,5 Hartiah Haroen6 1Postgraduate Program of Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, Indonesia; 2Postgraduate Program of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia; 3Department of Public Health, Faculty of Medicine, Universitas Syiah Kuala, Indonesia; 4Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; 5Education Program in Reproduction & Development, Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, 3168, Australia; 6Department of Community Health Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, Indonesia*These authors contributed equally to this workCorrespondence: Sidik Maulana, Faculty of Nursing, Universitas Padjadjaran, Jl. Ir. Soekarno KM. 21, Jatinnagor, Sumedang, 45363, Indonesia, Tel +6289662392294, Email [email protected] Rovy Pratama, Department of Public Health, Faculty of Medicine, Universitas Syiah Kuala, Jl. Teuku Nyak Arief No. 441, Kopelma Darussalam, Kec. Syiah Kuala, Kota Banda Aceh, Aceh, 23111, Indonesia, Email [email protected]: Maternity care within primary health facility settings is critical for reducing maternal and neonatal mortality in Indonesia. The aim of this study was to analyze research trends over the past decade to identify key strategies for improving maternity care in primary health care facilities in Indonesia. A bibliometric analysis was conducted using data from the Scopus database to map the research landscape and identify latent research topics in maternal health care. The analysis included keyword co-occurrence and network visualization, with assistance from ChatGPT-4.0 for enhanced identification and categorization of keywords. The identified research trends were used as surrogate variables representing the main concerns among researchers, experts, and funders. These variables were used to build strategies, which were then analyzed using SWOT (Strengths, Weaknesses, Opportunities, and Threats) by reflecting on the Indonesian context. The results revealed that key topics in maternity care included midwifery roles, pandemic resilience, and telemedicine. Based on SWOT analysis, most of the constructed strategies were found to have high external opportunities but low internal capabilities, indicating the need to strengthen internal resources. In conclusion, Indonesia must enhance its internal capabilities, particularly human resources and infrastructure, to effectively utilize external opportunities and improve maternal health outcomes.Keywords: antenatal care, bibliometric analysis, maternal health, primary health care, JKN progra
Diagnostic accuracy of preoperative ultrasonography-guided fine-needle aspiration biopsy in distinguishing malignancy in large thyroid nodules: A systematic review, meta-analysis, and meta-regression
No full textControversy persists regarding the effectiveness of ultrasonography-guided fine-needle aspiration biopsy (US-FNAB) in distinguishing malignancies in large thyroid nodules. The prevailing belief that larger thyroid nodules inherently pose a higher risk of malignancy has led to a common practice of suggesting thyroidectomy for large thyroid nodules. Herein, the aim of this study was to assess the diagnostic accuracy of preoperative US-FNAB for distinguishing malignancy in large thyroid nodules. A search for published records was carried out on 20 October 2023, utilizing the search feature available on PubMed, Scopus, Embase, and Google Scholar. Patients with large thyroid nodules (3 cm or larger) who underwent preoperative US-FNAB and postoperative histopathological tests were included. Related outcomes, including false positive (FP), false negative (FN), true negative (TN), true positive (TP), specificity, and sensitivity, were extracted from each study. Pooled specificity and sensitivity were estimated, and the summarized receiver operating characteristic (sROC) curve, along with the summarized area under the curve (sAUC), was calculated. Out of 133 articles identified across four databases, 10 studies with a total sample of 2752 patients were included. The overall diagnostic sensitivity was 72% (95%CI: 50–86%; p=0.00) and specificity was 96% (95%CI: 87–90%; p=0.00). The positive predictive value (PPV) and negative predictive value (NPV) were 93% (95%CI: 89–98%) and 75% (95%CI: 72–79%), respectively. sAUC was 93%, suggesting the diagnostic tool is accurate. Meta-regression analysis revealed that factors such as the number of samples, country (high-income vs upper-middle income), demographic characteristics (age and gender), and different thyroid size cut-off values did not significantly impact the sensitivity or specificity of US-FNAB. In conclusion, the present study confirms the reliability of US-FNAB in distinguishing malignancy in large thyroid nodules, emphasizing its role in reducing unnecessary thyroidectomy by identifying high-risk patients and challenging the conventional practice of routine thyroidectomy for large thyroid nodules
Metadata of Laccase Utilization in Wastewater Treatment from Scopus Database (1978-2022)
No full textThis is a .CSV file exported from Scopus database.</p
Adsorptive removal of Cd (II) using oil palm empty fruit bunch-based charcoal/chitosan-EDTA film composite
No full text- …
