6 research outputs found
Antidiabetic activity of curry leaves Murraya koenigii on glucose level, kidney and islets of langerhans in streptozotocin induced diabetes in rats
Get PDFIntroduction: This study examined the antihyperglycemic effect of curry leaves, Murraya koenigii “MK” aqueous extract, and to examine its possible protective effects on the Islets of Langerhans and kidneys in streptozotocin (STZ) induced diabetic rats. Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with “MK” control, diabetic control (non-treated with “MK”), diabetic treated with 200mg/kg MK aqueous leaf extract and diabetic treated with 400mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored. The animals were sacrificed on the 30th day; the kidney and pancreatic tissues were processed for histological studies. Results: The diabetic control group significantly (p<0.001) showed considerable loss of body weight and increase in blood glucose levels and degeneration of the glomeruli and renal convoluted tubules and atrophied islets with disintegration of β-cells. Treatment of diabetic rats with aqueous extract showed significant (p<0.001) improvement in blood glucose levels and body weight gain. The MK extract also caused an improvement in tissue injury induced by STZ injection in the kidney and endocrine pancreas. Conclusions: These findings highlighted the beneficial effects of MK aqueous extract against cellular oxidative damage in STZ-induced diabetic rats
Cytotoxic activity of various fractions of <i>S</i>. <i>crispus</i> DCM extract in breast cancer cell lines.
No full text<p>MDA-MB-231 (a) and MCF-7 (b) cells were treated with 100 μg/ml fractions (F1-F5) for 24 and 48 h. Percentage cell death was determined using the LDH assay and 15 μM tamoxifen (Tam) was used as the positive control.</p
Cytotoxic effect of compounds isolated from F3 on MCF-7 cells.
No full text<p>Cells were treated with 100 μM of the compounds (C1-C7) for up to 72 h and cell death was determined by LDH assay. Tamoxifen (15 μM) was used as the positive control.</p
Effects of Murraya koenigii leaves on glucose level, kidney and islets of langerhans in streptozocin induced diabetes in rats
No full textIn the present study, in addition to 30 days antihyperglycaemic effect of curry leaves of Murraya
koenigii "MK" aqueous leaf extract, we also examined its possible effects on the Islets of Langerhans
and nephro-protective potential in Streptozotocin (STZ) induced diabetic rats. Male Sprague Dawley rats
received a single dose of STZ (70 mg/kg) intraperitoneally to induce experimental diabetes. Rats were
randomized into five groups (n=6) of normal control, diabetic control (non-treated), and diabetic treated
with MK aqueous leaf extract. The fresh leaves of MK was extracted with distilled water and freeze-dried
to powder. Blood glucose levels and body weight were monitored gravimetrically. The animals were killed
on the 30th day, kidney and the pancreatic tissues were harvested, and the tissue specimens were fixed
in 10% formal saline for 48hrs, and processed for histological studies. Diabetic rats treated with aqueous
extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The
MK extract also showed improvements in tissue injury induced by STZ. Thus, these findings highlighted
the beneficial effects of curry leaf aqueous extract against STZ induced cellular damage and may exert
anti-hyperglycemic action and regeneration of kidney and islet cell induced in diabetic rats
The Antidiabetic Activity of Curry Leaves “Murraya Koenigii” on the Glucose Levels, Kidneys, and Islets of Langerhans of Rats with Streptozotocin Induced Diabetes
Get PDFBackground: The aims of this study were to explore the antihyperglycemic effect of curry leaves, Murraya koenigii "MK" aqueous extract, and to examine its possible protective effects on the islets of Langerhans and kidneys of streptozotocin (STZ) diabetic rats. Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with "MK" control, diabetic control (non-treated with "MK"), diabetic treated with 200 mg/kg MK aqueous leaf extract and diabetic treated with 400 mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored gravimetrically. The animals were sacrificed on the 30th day; the kidney and pancreatic tissues were processed for histological studies. Results: The diabetic group showed considerable loss of body weight and increase in blood glucose levels and degeneration of the glomeruli and renal convoluted tubules and atrophied islets with disintegration of β-cells. Treatment of diabetic rats with MK extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The MK extract also caused an improvement in tissue injury induced by STZ injection in the kidney and islets of Langerhans. Conclusions: These findings highlighted the beneficial effects of MK aqueous extract against cellular oxidative damage in STZ-induced diabetic rats
The Antidiabetic Activity of Curry Leaves “Murraya Koenigii” on the Glucose Levels, Kidneys, and Islets of Langerhans of Rats with Streptozotocin Induced Diabetes
No full textBackground: The aims of this study were to explore the antihyperglycemic effect of curry leaves, Murraya koenigii "MK" aqueous extract, and to examine its possible protective effects on the islets of Langerhans and kidneys of streptozotocin (STZ) diabetic rats. Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with "MK" control, diabetic control (non-treated with "MK"), diabetic treated with 200 mg/kg MK aqueous leaf extract and diabetic treated with 400 mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored gravimetrically. The animals were sacrificed on the 30th day; the kidney and pancreatic tissues were processed for histological studies. Results: The diabetic group showed considerable loss of body weight and increase in blood glucose levels and degeneration of the glomeruli and renal convoluted tubules and atrophied islets with disintegration of β-cells. Treatment of diabetic rats with MK extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The MK extract also caused an improvement in tissue injury induced by STZ injection in the kidney and islets of Langerhans. Conclusions: These findings highlighted the beneficial effects of MK aqueous extract against cellular oxidative damage in STZ-induced diabetic rats
