113 research outputs found
Supplementary_Information_of_scoparia_revised_updated – Supplemental material for Isolation and characterization of cytotoxic and anti-inflammatory constituents from Scoparia dulcis L
No full textSupplemental material, Supplementary_Information_of_scoparia_revised_updated for Isolation and characterization of cytotoxic and anti-inflammatory constituents from Scoparia dulcis L by Mohammad Nur-e-Alam, Sarfaraz Ahmed, Muhammad Yousaf, Shabana I Khan, Ramzi A Mothana and Adnan J Al-Rehaily in Journal of Chemical Research</p
Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk
No full textClutia lanceolata Forssk. (C. lanceolata) is a medicinal plant native to sub-Saharan Africa and the Arabian Peninsula. Phytochemical investigation of the aerial parts of C. lanceolata yielded twenty-one coumarins including methylthio and methylsulfinyl-coumarins. Thirteen of these compounds are reported here for the first time, named as cluteolin A to M. The remaining eight compounds are known but have not been associated previously with C. lanceolata. The structures of the undescribed compounds were elucidated from their 2D NMR and MS spectra. Single crystal X-ray analyses confirmed the structures of eleven compounds. As, in Saudi Arabian tradition, C. lanceolata has been reported to have anti-diabetic and anti-fungal properties, the coumarins were examined for their biological activity. Seven compounds strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets, with two compounds showing more than two-fold enhancement of insulin secretion, compared with the standard drug glimepiride
IMPACT OF HIGH INTENSITY STATIN THERAPY ON SHORT-TERM AND LONG-TERM OUTCOMES AFTER CORONARY ARTERY BYPASS GRAFTING: A SYSTEMATIC REVIEW AND META-ANALYSIS
No full textEffect of Incubation Duration on Broiler Breeder Eggs Hatchability and Post-Hatch Performance
No full textGrowth and Ionic Composition of Buttonwood (Conocarpus erectus L.) in Response to Soil Salinity and Water Stress
No full textSalinity and bad quality irrigation water is very common problem in Pakistan due to limited rainfall, more evapo-transpiration and high temperature. So, there is need to select salt and drought tolerant plants. In view of that a pot experiment was conducted to study the growth performance and ionic composition of Conocarpus erectus L. under saline and water stress conditions. Eight treatments (Control, 10 dSm-1, 20 dSm-1, 40 dSm-1, water stress, 10 dSm-1 + water stress, 20 dSm-1 + water stress, 40 dSm-1 + water stress) were evaluated in order to assess their effect on plant growth and ionic composition . At T8 (40 dSm-1 + water stress), plants did not survive. The data regarding growth parameters and physiological were recorded at different stages of plant growth. Plant ionic parameters including Na+, K+ were determined in stem, leaves and root after harvesting. The data were analyzed statistically. It is concluded that Conocarpus erectus L. can tolerate salinity up to 40dSm-1 with full water but at salinity and water stress level of 40 dSm-1 + water stress, there was no survival of even a single plant. Keywords: Growth, potassium status, buttonwood (Conocarpus erectus L.), soil salinity, water stres
The evaluation of various soil conditioners effects on the amelioration of saline-sodic soil
No full textThe soil salinity and sodicity collectively are the major problems in the soils of Pakistan and proved a continuous threat for the sustainability of agriculture. A pot study was planned to ameliorate such problematic soils and for this purpose different soil conditioners were used viz. gypsum @ 39.078 g pot-1 soil gypsum requirement, Citric acid (CA) @ 29.067 g pot-1, H2SO4 @ 11.24 ml pot-1 and polyvinyl alcohol (PVA) @ 19.98 g pot-1 and control without any amendment and wheat was grown as a test crop. The results showed that maximum decrease in pH and SAR were 8.31 and 12.04 (mmol L-1)1/2 by application of H2SO4 and citric acid respectively. Similarly H2SO4 and citric acid treatment show significant results related to crop growth and yield. The maximum plant height (63.33cm), number of tillers (4.63), photosynthetic rate ((2.83 µmolm-2s-1), transpiration rate (0.63 molm-2s-1), stomata conductance (0.53 molm-2s-1), were by application of H2SO4. while the results related to grain yield were as maximum grain yield by H2SO4 was (15.67 g) and minimum grain yield was observed with control (6.73g). Moreover the decrease in grain yield was as H2SO4 (9.98 g) > citric acid (8.33 g) > PVA (7.36 g) > gypsum (6.12 g) > control (5.53g). From this experiment it was concluded that H2SO4 showed quick impact on soil physicochemical properties and growth parameters but gypsum and citric acid were long term and sustainable source to reclaim and to make saline-sodic soils more productive as compare to other soil conditioners. Keywords: soil conditioners, amelioration, saline-sodic soi
Positive Predictive Value of Magnetic Resonance Imaging in Intradural Spinal Tumors Taking Histopathology as Gold Standard
No full textObjective: To observe the positive predictive value of MRI, taking histopathology as gold standard in detecting spinal intradural tumors.Materials and Methods: Total 180 cases were included through non-probability purposive sampling, at Ganga Ram Hospital, Radiology department, Lahore. The radiological diagnosis obtained through MRI, was observed. The cases fit in inclusion criteria were underwent surgery and their histopathological findings were observed. Comparison between the outcomes of MRI and histopathology were undertaken, keeping histopathology as gold standard. Positive predictive value of MRI in the diagnosis of intradural spinal tumor was calculated andpresented in the form of percentages and frequency.Results: There were total 180 patients presenting in OPD with the mean age of 45.71 ± 13.57 years. There were 112 (62%) male. Male to female ratio was 1.6:1. There were 134 (74.4%) cases who were positive for malignant spinal intradural tumor on histopathology showing the PPV of MRI as 74.4%.Conclusion: Magnetic Resonance Imaging is very beneficial imaging tool for early diagnosis of spinal cord tumors
Problems and Challenges of Internally Displaced Persons in the wake of Operation Zarb-e-Azb: Case Study of District Lakki Marwat
No full textThe Operation Zarb-e-Azb was a full-scale operation launched against terrorists and their hideouts in North Waziristan. The operation resulted in massive number of IDP’s displaced from their homes. They settled in many different parts of Pakistan, including Lakki Marwat. They have experienced severe problems and challenges since the time they were displaced from their native area. The most prominent were the homes, food and health as their basic needs and problem. These problems were coupled with a lot of other related problems like hygiene, access to education, loss of property, identity issues, and the problem of assimilation, security threats and a denial of political rights on a general scale. The paper will try to discuss and analyze the level and extent of these problems and the response of the government and other non-government agencies to tackle with these issues.
Key Words: Identity, IDP, s, Hygiene, Food, Health, Political right
Fast Fractional Fourier Transform-Aided Novel Graphical Approach for EEG Alcoholism Detection
No full textGiven its detrimental effect on the brain, alcoholism is a severe disorder that can produce a variety of cognitive, emotional, and behavioral issues. Alcoholism is typically diagnosed using the CAGE assessment approach, which has drawbacks such as being lengthy, prone to mistakes, and biased. To overcome these issues, this paper introduces a novel paradigm for identifying alcoholism by employing electroencephalogram (EEG) signals. The proposed framework is divided into various steps. To begin, interference and artifacts in the EEG data are removed using a multiscale principal component analysis procedure. This cleaning procedure contributes to information quality improvement. Second, an innovative graphical technique based on fast fractional Fourier transform coefficients is devised to visualize the chaotic character and complexities of the EEG signals. This elucidates the properties of regular and alcoholic EEG signals. Third, thirty-four graphical features are extracted to interpret the EEG signals’ haphazard behavior and differentiate between regular and alcoholic trends. Fourth, we propose an ensembled feature selection method for obtaining an effective and reliable feature group. Following that, we study many neural network classifiers to choose the optimal classifier for building an efficient framework. The experimental findings show that the suggested method obtains the best classification performance by employing a recurrent neural network (RNN), with 97.5% accuracy, 96.7% sensitivity, and 98.3% specificity for the sixteen selected features. The proposed framework can aid physicians, businesses, and product designers to develop a real-time system
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