735 research outputs found
Current use and potential role of bevacizumab in the treatment of gastrointestinal cancers
No full textJia Li, Muhammad Wasif SaifYale Cancer Center, Yale School of Medicine, New Haven CT, USAAbstract: Angiogenesis is essential for cancer growth and metastasis. Vascular endothelial growth factor (VEGF) is a key modulator of angiogenesis. In addition, overexpression of VEGF is correlated with advanced disease and poor prognosis. Bevacizumab, a recombinant humanized anti-VEGF monoclonal antibody, is the first anti-angiogenic agent approved by Food and Drug Administration for use in treatment of human solid cancers. Although bevacizumab has received most attention for first-line treatment of advanced colorectal and nonsmall-cell lung cancer, there is a rapidly growing body of evidence for its efficacy in treatment of a number of other solid tumors. We present the current status and potential use of bevacizumab therapy in gastrointestinal cancers.Keywords: advanced colon cancer, angiogenesis, bevacizumab, chemotherapy, metastatic, targeted therapy, vascular endothelial growth factor, gastric cancer, pancreatic cancer, hepatocellular cance
Corrigendum
No full textCorrigendum to ‘Harnessing gemcitabine metabolism: a step towards personalized medicine for pancreatic cancer’ by Muhammad Saif, Yoomi Lee and Richard Kim, Therapeutic Advances in Medical Oncology 2012; 4(6):341-6. DOI: 10.1177/1758834012453755 . The corresponding author would like to note their name should be recognized as Muhammad Wasif Saif (Saif MW) and not as Muhammad Saif (Saif M) in this article
Folio
No full textZahoor Hussain Chohan-Editorial; Riaz Hussain-Article-Muhammad (SAW) and the People of India and Pakistan. pp. 7-11; Ahsan Waseem-Poetry-The Land of the Pious. pp. 11; Sultan Khan-Article-Quaid as a Political Philosopher. pp. 12-14; Aniza Zaheer-Article-Building-Up the National Fiber. pp. 15-19; Muhammad Tanvir-Essay-Importance of Discipline. pp. 19-20; Hameed Nizamee, Edited by Saleem Mansur Khalid-Article-Iqbal and his Urdu Poetry a General Survey Based on his Urdu Works. pp. 21-33; Amjad Ali Bhatti-Essay-The Prophet's Message to the Muslims. pp. 34-36; Arif Qureshi-Poetry-Salute to the Quaid. pp. 36; Tahir Kamran-Essay-Rise of Muslim History Writing. pp. 37-39; Muhammad Ahsan Pasha-Essay-Where do we Stand. pp. 40-42; Irshad-ul-Hasan-Poetry-The Walls of Glass. pp. 43-44; Rubina Nazir Chohan-Poetry-Gift. pp. 44; Sohail Ahmad Sharyar-Essay-What Is Literature. pp. 45-47; Muhammad Ahsan Pasha-Poetry-A Funny Commentary on Chaucer. pp. 47-48; Irshad-ul-Hasan-Article-Symbolism. pp. 49-61; Gilani Kamran-Essay-Discovering Folklore. pp. 62-64; Mohammad Tanvir Butt-Essay-Father of the Nation. pp. 65-67; Tariq Hameed Rathore-Poetry-Pleasant Manner. pp. 68; Syed Saadat Mehdi-The Days at College. pp. 68-69; Muhammad Akmal-Three Narrations. pp. 69-70; Wasif Rashid-Friendship & Friends. pp. 71; Ateeq-ur-Rahman-May You Have. pp. 71; Ali Awais-Quotes. pp. 72; Hammad Raza-Definitions. pp. 72; Akhlaque Ahmad-Mind and its Problems. pp. 73-74; Kamran Mahboob-Notice for the Students. pp. 75; Sana-ur-Rahman-Article-Emancipation of Women. pp. 76-80; Dalip Kumar Rajpoot-Best Use of Youth. pp. 80; Akhtar Ali Khan-Essay-Way to Economic Progress. pp. 81-82; Zia-ul-Haq-Essay-The World First Democracy. pp. 82-83; Zahor Hussain Chohan-On the Eve of Retirement. pp. 84; Folio [Urdu]. 272 p.College Buildings. after English title; Quaid-e-Azam. after contents; Allama Iqbal. 1 page after contents; Dr Shaukat Ali, Principal. 2 pages after contents; Prof Talat Mahmood. 3 pages after contents; Students Union 1988-1989. after page 84; Editorial Board 1988-89. after editorial Urdu pag
Organizational Culture and Performance: An Empirical Study of SMEs in Pakistan. Journal of Management and Research,
No full textThis study aims to identify the prevailing type of culture and its relationship with performance in SMEs operating in Pakistan. Using competing value framework, the cultural profile and dominant characteristics of SMEs are identified and investigated to ascertain their implied relationship with organizational performance on the basis of certain self-assessment variables. For this purpose, primary data was collected form SME employees through a self-administered survey questionnaire. The results revealed that ‘hierarchy’ culture is the prevailing type of culture and a statistically significant relationship exists between organizational culture and performance among the sampled SMEs. The study concludes with certain important insinuations for theory and practice especially concerned with SMEs
A Quality 4.0 Assurance Framework for the Higher Education Institutes
No full text[EN] This article presents a framework for the implementation of Quality 4.0 aspect in the higher education institute. Quality 4.0 is a major domain of Industry 4.0 revolution. Beside the industry, educational institutes are also embracing the new technology-based framework, which does not only revolutionize the educational system, but also impact their performance.In this research, a comprehensive framework for the implementation of Quality 4.0 is presented. The enablers and the components of Quality 4.0 are discussed in detail. The article also discusses the implementation of the framework, consisting of big data analysis, SWOT analysis of the institute, implementation of documentation, digitalization and record management, ERP system and finally the key performance indicators (KPIs).The framework is specially designed for the higher education institute for the consistency and standardization, through the latest technology and digitization. Lodi, S.; Shaikh, A.; Wasif, M.; Tufail, M.; Butt, F. (2022). A Quality 4.0 Assurance Framework for the Higher Education Institutes. En 8th International Conference on Higher Education Advances (HEAd'22). Editorial Universitat Politècnica de València. 725-732. https://doi.org/10.4995/HEAd22.2022.14032OCS72573
Sorafenib-Induced Acute Pancreatitis
No full textNo abstract available.Image: Sorafenib BRAF labeled (Author: Nhevitt; Wikimedia Commons
Mitomycin-Induced Interstitial Pneumonitis in a Patient with BRCA2 Associated Metastatic Pancreatic Carcinoma
No full textNo abstract available.Image: Space-filling model of the mitomycin molecule (Author: Jynto (talk); Wikimedia Commons
Retracted: Healthcare providers knowledge, attitude and behaviour towards breast cancer diagnosis and treatment in Malaysia – a mini systematic review
No full textThis article previously published in Volume 15 Issue 10 of this journal in September 2016 has been retracted in line with the guidelines from the Committee on Publication Ethics (COPE, http://publicationethics.org/resources/guidelines)Retracted: Azeem E, Gillani WS, Poh V, Sulaiman SAS. RETRACTED: Healthcare providers’ knowledge, attitude and behaviour towards breast cancer diagnosis and treatment in Malaysia – a mini systematic review. Trop J Pharm Res 2016; 15(9):2041-2045 doi: http://dx.doi.org/10.4314/tjpr.v15i9.32From the EditorOur attention was drawn to the earlier publication of similar data by the authors and some others in Asian Pacific Journal of Cancer Prevention (doi 10.7314/APJCP.2015.16.13.5233) under the title, “Knowledge, Attitude and Behavior of Healthcare Providers towards Breast Cancer in Malaysia: a Systematic Review” which was confirmed. The corresponding author, Syed Wasif Gillani was contacted but failed to respond to communication in this respect.25 November 2018Keywords: Healthcare provider, Breast cancer, Knowledge, Attitude, Behavior, Systematic review, Malaysi
Adjuvant Therapy of Pancreatic Cancer: Beyond Gemcitabine
No full textThere is no consensus on what constitutes “standard” adjuvant therapy for pancreatic cancer. This controversy derives from several studies, each fraught with its own limitations. Standards of care also vary somewhat on the geography as chemo-radiotherapy followed by chemotherapy or vice versa is considered the optimal therapy in North America (GITSG, RTOG) while chemotherapy alone is the current standard in Europe (ESPAC-1, CONKO, ESPAC-3). The high rate of locoregional failure following surgical resection for adenocarcinoma of the pancreas has made it clear that some form of adjuvant therapy should be considered in these patients. A phase II study was presented at the 2011 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium to assess the effect of the addition of algenpantucel-L immunotherapy to standard adjuvant therapy on survival in patients with resected pancreas cancer (Abstract #236). The author reviews the abstract in the context of our previous knowledge.Image: Hyperacute rejection and immunotherapeutic applications
Pak-India Trade Relations: From Rivalry to Friendship
No full textThis paper was presented in an International Conference, “Socio
Economic and Cultural Relations between Pakistan and India” University
of the Punjab, Lahore, Pakistan (25th-27th November, 2016)Syed Wasif Azim was a visiting scholar in the Jackson School.Pakistan and India are two neighboring countries, whose inhabitants share a long history and have many commonalities, but relations between both the countries have been strained by different activities and issues since birth of the two. Like other
relations the Trade relations between Pakistan and India have never been good and productive since last six decades. This has
hampered the economy of Pakistan and India, and has contributed a lot to the increasing level of poverty in both the
countries. Using the lens of commercial peace theory, this study explores that Trade relations between Pakistan and India need a
revival to combat the economic problems of the people on both sides of the border. Also it argues that trade, in spite of its
economic benefits will contribute to peace between the countries and the region. It explains that there is a long list of issues
contributing to this situation, needing focus to achieve the target of peaceful trade relations. This study focuses only three
important of these i.e. Chabahar Port Project verses Gawadar Port, Most Favored Nation status (MFN) issue and Regional
Politics involved in this regard. Furthermore this paper will give a list of suggestions important for improving the present status
of Pak-India trade relations. It subsequently argues that both the countries shall enhance bilateral trade to foster peace in the
region, as is advocated by commercial peace theory
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