186,346 research outputs found
Cinquième colloque d'hydrologie en pays calcaire Octobre 1992, Neuchâtel-Suisse
No full textMudry Jacques. Cinquième colloque d'hydrologie en pays calcaire Octobre 1992, Neuchâtel-Suisse . In: Karstologia : revue de karstologie et de spéléologie physique, n°22, 2e semestre 1993. p. 57
Cinquième colloque d'hydrologie en pays calcaire Octobre 1992, Neuchâtel-Suisse
No full textMudry Jacques. Cinquième colloque d'hydrologie en pays calcaire Octobre 1992, Neuchâtel-Suisse . In: Karstologia : revue de karstologie et de spéléologie physique, n°22, 2e semestre 1993. p. 57
Diabetes, obesity and exercise in skeletal muscle : effects on gene expression and DNA methylation
No full textType 2 diabetes, obesity and depression are growing concerns for human health. Physical exercise is a known protective factor against these disorders, although the underlying mechanisms are incompletely understood. The studies in this thesis aim to increase the understanding of mechanisms controlling gene expression and DNA methylation in the context of type 2 diabetes, obesity and exercise.TWIST1 and TWIST2 proteins play an important role in embryonic muscle development, inflammation and tumor metabolism. We demonstrated that Twist1 or Twist2 overexpression in mature skeletal muscle favors glycolysis and increases the expression of pro-inflammatory cytokines. Gene expression of TWIST1 and TWIST2 is unaltered by obesity, type 2 diabetes or exercise training.Decreased circulating kynurenine levels are associated with resistance to depression. Kynurenine is transformed into kynurenic acid by kynurenine aminotransferases (KATs). Exercise training and PGC1α induce expression of KATs in skeletal muscle. We report that a single bout of exercise acutely decreased plasma kynurenine, while concomitantly increasing kynurenic acid in both type 2 diabetic and healthy subjects. Exercise-induced changes in kynurenine metabolism were independent of mRNA expression of the KATs. Kynurenine levels correlated with body mass index, suggesting kynurenine metabolism may link obesity and depression.Exercise and diet affect skeletal muscle insulin sensitivity and DNA methylation. Using genome-wide approaches, we unraveled the effect of exercise on the skeletal muscle methylome. Training and high-fat diet, but not in vitro contraction, lead to epigenetic changes in the promoter of Sprouty RTK Signaling Antagonist 1 (Spry1), a gene involved in muscle stem cell quiescence. We found DNA methylation of Spry1 increased binding of nuclear proteins to the promoter.Insulin is a metabolic and growth promoting hormone. Using genome-wide approaches, we unraveled the effect of insulin on the skeletal muscle methylome. We observed that insulin treatment of skeletal muscle in vitro increased DNA methylation of the death-associated protein Kinase 3 (DAPK3). Conversely, DAPK3 DNA methylation was reduced in type 2 diabetic subjects compared to controls. A glucose challenge further decreased DAPK3 methylation suggesting that additional factors in the systemic milieu may affect DAPK3 DNA methylation.Collectively, our results indicate that TWIST proteins affect skeletal muscle metabolism and inflammation. We provide a potential mechanism for the anti-depressive effects of exercise and shed new light on the complex interplay between metabolic conditions, skeletal muscle and DNA methylation. We provide a new insight in the protective effect of exercise or the pathophysiology of type 2 diabetes and obesity, opening opportunities for improvements in the management and treatment of metabolic diseases.List of scientific papersI. Mudry JM, Massart J, Szekeres FL, Krook A. TWIST1 and TWIST2 regulate glycogen storage and inflammatory genes in skeletal muscle. J Endocrinol. 2015 Mar; 224(3):303-13. https://doi.org/10.1530/JOE-14-0474 II. Mudry JM, Alm PS, Erhardt S, Goiny M, Fritz T, Caidahl K, Zierath JR, Krook A, Wallberg-Henriksson H. Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes. Diabetes Metab Res Rev. 2016 Mar 4. https://doi.org/10.1002/dmrr.2798 III. Mudry JM, Kirchner H, Chibalin AV, Krook A and Zierath JR. Changes in skeletal muscle DNA methylation in rats following endurance training and high-fat diet. [Manuscript]IV. Mudry JM, Lassiter DG, Nylén C, García-Calzón S, Näslund E, Krook A, Zierath JR. Insulin and glucose alter death-associated protein kinase 3 (DAPK3) DNA methylation in human skeletal muscle. [Manuscript]</p
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Jacques Mudry (1987) : Apport du traçage physico-chimique naturel à la connaissance hydrocinématique des aquifères carbonates. Thèse de doctorat d'Etat ès-Sciences, Universités de Franche-Comté-Besançon-Avignon
No full textJacques Mudry (1987) : Apport du traçage physico-chimique naturel à la connaissance hydrocinématique des aquifères carbonates. Thèse de doctorat d'Etat ès-Sciences, Universités de Franche-Comté-Besançon-Avignon. In: Karstologia : revue de karstologie et de spéléologie physique, n°10, 2e semestre 1987. La table ronde franco-polonaise (1-8 juin 1987) p. 63
Jacques Mudry (1987) : Apport du traçage physico-chimique naturel à la connaissance hydrocinématique des aquifères carbonates. Thèse de doctorat d'Etat ès-Sciences, Universités de Franche-Comté-Besançon-Avignon
No full textJacques Mudry (1987) : Apport du traçage physico-chimique naturel à la connaissance hydrocinématique des aquifères carbonates. Thèse de doctorat d'Etat ès-Sciences, Universités de Franche-Comté-Besançon-Avignon. In: Karstologia : revue de karstologie et de spéléologie physique, n°10, 2e semestre 1987. La table ronde franco-polonaise (1-8 juin 1987) p. 63
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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