1,721,022 research outputs found

    Chest drainage combined with intracavitary therapy in neoplastic pleural effusion: comparison of three different protocols | [Il drenaggio toracico associato alla terapia endocavitaria nei versamenti pleurici neoplastici: confronto di tre diverse metodiche.]

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    Twenty-eight patients with malignant pleural effusion observed in a two year period were treated with intrapleural instillation of different substances: Tetracycline, Corynebacterium parvum and Beta-Interferon. Different results were observed: complete responsiveness (no recurrence of pleural effusion within three months); partial responsiveness (recurrence of moderate pleural effusion within one month after drainage removal); insufficient responsiveness (recurrence of massive effusion within one month). Among patients treated with Tetracycline seven complete, five partial and one insufficient responses were observed. Instillation of Corynebacterium parvum allowed two complete, two partial and three insufficient responses. Finally, in the group treated with Beta-Interferon complete responsiveness was obtained in just one patient, partial responsiveness in three, while the treatment was insufficient in the last two. These results suggest pleural drainage is the best treatment in patients with malignant pleural effusion, however, the association of Tetracycline instillation allows better results

    Laparoscopic management of a giant hiatal hernia with gastric volvulus: a case report

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    Giant hiatal hernias represent a small subset of diaphragmatic hernial disease. Characterized by supramesocolic or multidistrict intrathoracic evisceration, they are at greater risk of complications due to the tendency to strangulation and to meso- or organoaxial volvuli as a result of the end -stage of dysautonomic and dysmotilic processes involving the esophagogastric junction. Giant hiatal hernias fall into the category of well-being pathologies and are often concomitant with obesity. Since congenital aetiology is rare, the underlying pathophysiological mechanisms are increased intra-abdominal pressure, morbid obesity, Caucasian race. Nevertheless, this is usually an incidental finding in the absence of suggestive clinical findings and if symptoms arise, they are usually nonspecific (epigastralgia, bloating, reflux). On the other hand, the occurrence of hematemesis, epigastric or atypical chest pain represent worrisome symptoms that may underlie the onset of local complications such as incarceration and volvuli. Surgical management usually appears challenging, usually involving inveterate compartment defects as far as tissue loss of strength making repair complex and usually demanding mesh cruroplasties. A minimally invasive approach has a double utility: an accurate direct dissection control and the undeniable advantages of postoperative functional recovery. However, superiority of minimally invasive surgical approach still claims debate, especially concerning long-term outcomes. A clinical case of a patient with a giant hiatal hernia with organo-axial gastric volvulus and laparoscopic surgically repaired is reported

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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