1,721,082 research outputs found
Regional plus systemic chemotherapy: An effective treatment in recurrent non-small cell lung cancer
No full textAims: This study was undertaken to determine the activity and toxicity of regional chemotherapy using an isolated thoracic perfusion (ITP) technique as second-line treatment for patients with advanced and recurrent non-small cell lung cancer (NSCLC). Methods: Eighteen patients with relapsed NSCLC confined to the thoracic region entered the study and received regional chemotherapy using ITP plus low-dose systemic chemotherapy. All 18 patients had been pre-treated with some form of chemotherapy, surgery and/or radiotherapy. The cytostatic regimen had two components: (1) ITP using mitomycin 10 mg/m2, navelbine 25 mg/m2 and cisplatin 30 mg/m2 on day 1; (2) systemic chemotherapy with 5-fluorouracil 250 mg/m2 and cisplatin 20 mg/m2 given as a continuous infusion over 24 h on days 1-4. Results: All 18 patients were assessable for toxicity, tumour response and survival. There were 10/18 responses (CR 0; PR 10): a response rate of 56%. Side-effects were transient and acceptable. No treatment-related death occurred. Median survival was 21 months and the 1-year survival rate was 75%. Conclusion: Regional chemotherapy using ITP plus low-dose systemic chemotherapy is effective in recurrent advanced NSCLC, with an encouraging survival outcome. © 2001 Harcourt Publishers Ltd
I geni che codificano per le tripsine di Anopheles Gambiae e le regioni di DNA che controllano l’espressione nell’intestino
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Real-time or Full-precision CRS Imaging Using a Cloud Computing Portal: Multi-offset GPR and Shear-wave Reflection Data
No full textThe presented cloud-computing portal allows automated imaging of near-surface structures either in full-precision using a global simultaneous search for the best fitting spatial CRS stacking operator or in real-time using a pragmatic sequence of line searches. The simultaneous search even though computationally very expensive becomes necessary when the pragmatic search fails due to strongly varying velocities, low CMP fold and high noise levels. In our first case study we apply real-time imaging by reprocessing multi-offset Ground Penetrating-Radar data with a good signal/noise ratio. Generating stacked and prestack time migrated sections, consistent with conventional results, required less than 10 minutes. In our second case study we analyze a challenging SH-wave seismic reflection data, recorded in an urban environment, where a high level of ambient noise and landfills below the sealed surface down to 2 m depth resulting from recent reconstruction work hampered seismic data quality severely. Here, we successfully applied our newly developed full-precision CRS imaging approach in addition to conventional CMP stack aided by VSP. In this urban environment, the relevance of applying both, high resolution SH-wave seismic and VSP surveys was demonstrated. Two recently drilled wells confirm the aquiclude to be found as predicted by the seismic forecast
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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