1,721,133 research outputs found
Can glargine reduce the number of lung infections in patients with cystic fibrosis-related diabetes?
No full textFranzese A, Spagnuolo MI, Sepe A, Valerio G, Mozzillo E, Raia V. Related Articles, Links Can glargine reduce the number of lung infections in patients with cystic fibrosis-related diabetes? Diabetes Care. 2005 Sep;28(9):2333. No abstract available
La sindrome metabolica: diagnosi ancora controversa?
No full textLa sindrome metabolica (SM) comprende un insieme di fattori di rischio cardiometabolico
che si associano ad un aumento delle complicanze cardiovascolari nell’adulto. La base
fisiopatologica di questa costellazione è inquadrabile nell’insulino-resistenza, che spesso
si associa alla presenza di adiposità viscerale, quest’ultima ne rappresenta il principale
marker. Altri elementi che identificano la SM sono le alterazioni glicemiche, la dislipidemia
e l’ipertensione. In età pediatrica non esiste un unanime consenso sulla definizione di
SM e sul significato clinico concreto del rischio cardiometabolico sia dei singoli elementi
che la identificano sia dell’insieme di essi. Tuttavia i soggetti che presentano più fattori di
rischio hanno un aumentato rischio cardiometabolico rispetto a quelli che non mostrano
questa associazione. Pertanto il riscontro di uno o più fattori di rischio che costituiscono
la SM deve indurre il pediatra a stimolare l’aderenza ad uno stile di vita sano del bambino
sovrappeso/obeso e del suo nucleo familiare
Screening of glucose metabolism derangements in pediatric cystic fibrosis patients: how, when, why
No full textDiabetes mellitus is the most common comorbidity in cystic fibrosis (CF), occurring in a variable number of children and adolescents. Glucose metabolism derangements (GMDs) are responsible for a negative impact on the general health status of CF patients. Screening of GMDs is important since the youngest age and should be performed by means of OGTT, including its intermediate times, that could detect other non-traditional GMDs. Insulin treatment, administered before overt diabetes, could be beneficial in reducing the number of pulmonary infections, in improving both pulmonary function and nutritional status. Early screening of GMDs in pediatric age can exert an important preventing role regarding all aspects of health status of patients with CF
Editorial: New Insights in Diagnosing and Treatment of Glucose Disorders and Obesity in Children and Adolescents
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
One-year glargine treatment can improve the course of lung disease in children and adolescents with cystic fibrosis and early glucose derangements
No full textBACKGROUND: Diabetes increases morbidity and mortality in cystic fibrosis (CF) patients, but several studies indicate that also prediabetic status may have a potential impact on both nutrition and lung function.
OBJECTIVE: To evaluate the effect of glargine on the clinical course in CF patients with early glucose derangements.
METHODS: CF population was screened for glucose tolerance. CF patients with age >10 yr were screened with fasting hyperglycemia (FH). CF patients with age >10 yr without FH and those with age <10 yr with occasional FH were evaluated for glucose abnormalities on the basis of oral glucose tolerance test and/or continuous glucose monitoring system. All CF patients with glucose derangements were enrolled in an open clinical trial with glargine. Body mass index (BMI) z-score, forced expiratory volume in the first second (FEV(1)), number of acute pulmonary exacerbations and hemoglobin A1c, were as outcome measures at baseline and after 1 yr of treatment.
RESULTS: After 12 months of therapy, BMI z-score improved only in patients with baseline BMI z-score less than -1 (p = 0.017). An 8.8% increase in FEV(1) (p = 0.01) and 42% decrease in the number of pulmonary exacerbations (p = 0.003) were found in the whole group compared with previous 12 months of therapy.
CONCLUSION: Glargine could represent an innovative strategy to prevent lung disease progression in CF patients with early glucose derangements. Larger controlled trials are needed to better clarify the effects of insulin on clinical status in CF patients with early glucose derangements
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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