1,720,955 research outputs found
SSRIs vs. SNRIs: Personalized treatment of depression and decision algorithms for choosing antidepressant medications [SSRIs vs. SNRIs: Trattamento personalizzato della depressione ed algoritmi decisionali per la scelta del farmaco antidepressivo]
No full textIntroduction: Major Depressive Disorder (MDD) is a major cause of morbidity worldwide. Lifetime prevalence varies widely by country, and is estimated around 17% in the United States. MDD is currently the leading cause of disease burden in North America and other high-income countries, and is the fourth-leading cause of disease burden worldwide. According to the World Health Organization, by the year 2030, MDD is predicted to become the secondleading cause of disease burden worldwide after HIV. MDD is usually recurrent and national practice guidelines recommend maintenance pharmacotherapy for most patients with a history of major depressive episodes, owing to their favorable risk/benefit ratio. Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly endorsed as a first line treatment for MDD. Indeed, SSRI have enjoyed wide popularity as a result of their selective pharmacology and the consequently better tolerability and lesser toxicity than the first-generation antidepressants. However, a high percentage of patients fail to achieve complete remission when treated with a SSRI. Among the symptoms that fail to improve are often included fatigue, low energy and loss of interests, i.e. those symptoms that may be associated with dopaminergic and noradrenergic systems dysfunction. Such symptoms may respond to medications with a noradrenergic and/or dopaminergic component to their pharmacology, such as bupropion and duloxetine. Conclusions: This paper briefly reviews and comments on the heterogeneity of depression, on the pharmacodynamics differences among the various available antidepressants and on the need to personalize the treatment of depression based on the symptom presentation
Risperidone long-acting injection as monotherapy and adjunctive therapy in the maintenance treatment of bipolar I disorder
No full textImportance of the field: It is very rare for patients with bipolar disorder to have a single episode of mania or depression over a lifetime and the vast majority of these individuals need long-term prophylactic/maintenance treatment. However, treatment nonadherence is a major issue for close to half of subjects with bipolar disorder who are prescribed medications. Risperidone long-acting injection (LAI) has proven efficacious for the maintenance phase of bipolar disorder and may mitigate the problem of nonadherence in the substantial group of patients for whom this is a significant concern. Areas covered in this review: This paper comprises a review and commentary regarding the use of risperidone LAI in bipolar disorder. What the reader will gain: The reader will gain an understanding regarding the risks and benefits of risperidone LAI in bipolar disorder. We review the available evidence and discuss the strengths and weaknesses of published studies, providing an opinion about the clinical usefulness of risperidone LAI as well as suggestions for future research. Take home message: The use of risperidone LAI, through improved adherence, has the potential to ameliorate the course of bipolar disorder. © 2010 Informa UK Ltd
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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