1,721,048 research outputs found
Multiplex genotyping of CYP3A4, CYP3A5, CYP2C9 and CYP2C19 SNPs using MALDI-TOF mass spectrometry
No full textBackground: Pharmacogenetics is the study of genetic variations that cause alterations in drug level, drug
response and adverse drug reactions. SNPs found in CYP450 genes have the greatest genetic influences
on interindividual variability in drug bioavailability. The polymorphic nature of these genes may modulate
several enzyme levels that affect individual responses to pharmacological treatment. Among them, CYP3A4,
CYP3A5, CYP2C9 and CYP2C19 isoforms of CYP450 enzymes are involved in the metabolism of many
commonly prescribed drugs. Aims: In this study, we would like to develop a CYP450 genotyping platform
that could lead a complete definition of a patient’s metabolic genotype in order to improve the clinical
outcome of some drug treatments. Materials & methods: We used matrix-assisted laser desorption/
ionization time-of-flight mass spectrometry (MALDI-TOF MS) (Sequenom®) to develop a SNP genotyping
method. Results: This MALDI-TOF-based multiplexing system allows the simultaneous and efficient
genotyping of a set of CYP450 gene polymorphisms. Conclusion: The multiple CYP450 gene testing achieved
with this application can be used to develop diagnostic tests to predict drug responses and clinical outcomes
Signal-to-Noise Ratio and Autocorrelation Function of the Image Intensity in Coherent Systems:Sub-Rayleigh and Super-Rayleigh Conditions
No full textStudio dell’insediamento protostorico in un’area della Sardegna centro-occidentale tramite strumenti GIS ed analisi multivariate
No full textThe authors analyze, as a sample-area, the region that includes the municipality of Mogoro, in central-western Sardinia, with the objective to reconstruct, through the study of the settlements and their relationships, some economic and social aspects of the human groups of nuragic culture that inhabited this area between the 18th and the 8th century BC. The territory is located at the foot of Monte Arci, along the Mogoro river that runs through the southern part of the plain of the Campidano of Oristano. The area has been intensively investigated from the half of the past century; an in-depth stratigraphic investigation was carried out since 1994 near the nuragic site of Cuccurada, the main center of an articulated territorial system including a rich network of monuments related to the nuragic civilization. The results are illustrated through various research methods: GIS, with the application of spatial analysis tools, and multivariate analysis (cluster and principal components analysis) that allowed to set out new hypotheses on occupation and populating dynamics and to identify among pre-historical monuments one or more homogeneous and distinguishable groups, resulting from a database in which geomorphological characteristics are recorded. A hierarchical organization and a specific criterion for exploiting and monitoring the landscape have been developed, in which settlement choices depend on functionality criteria, having nuraghi and villages a key role on the strategic control of the territor
Le sepolture altomedievali del pavimento della chiesa della SS. Trinità a Venosa: primi dati antropologici
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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