1,062 research outputs found
D.H. Lawrence, La Volpe, traduzione e cura di Stefania Michelucci, edizione bilingue
No full textIt is the bilingual and critical edition of D.H. Lawrence's The Fox in the series, Elsinore, Collana di Classici Inglesi, edited and translated by Stefania Michelucci
The volume consists of a long introduction to the text, pp 11-37, of a biographical article on the author and his work (l'autore e l'opera), pp. 39-45), of a note to the text (pp. 47-48) (English and Italian, page to page, pp. 49-227) of explicatory notes (pp. 229-243) and of a biographical section (pp. 245-252)
Viability, growth and cell function evaluation of cells inside sponge-like scaffolds based on PLLA and agarose
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Ricordo di Stefania Rossi Minutelli
No full textThe author commemorates Stefania Rossi Minutelli – librarian at the Marciana National Library from 1971 to 2005, who died on october 10th, 2008 – remembering her professional career and her role within the Italian Library Association.L'autore ricorda con affetto e stima professionale Stefania Rossi Minutelli – bibliotecaria marciana dal 1971 al 2005, scomparsa nell'ottobre 2008 – ripercorrendo il tratto di strada fatto insieme all'interno dell'Associazione Italiana Biblioteche e del mondo bibliotecario italiano
Poly(vinyl alcohol)/gelatin Hydrogels Cultured with HepG2 Cells as a 3D Model of Hepatocellular Carcinoma: A Morphological Study
No full textIt has been demonstrated that three-dimensional (3D) cell culture models represent fundamental tools for the comprehension of cellular phenomena both for normal and cancerous tissues. Indeed, the microenvironment affects the cellular behavior as well as the response to drugs. In this study, we performed a morphological analysis on a hepatocarcinoma cell line, HepG2, grown for 24 days inside a bioartificial hydrogel composed of poly(vinyl alcohol) (PVA) and gelatin (G) to model a hepatocellular carcinoma (HCC) in 3D. Morphological features of PVA/G hydrogels were investigated, resulting to mimic the trabecular structure of liver parenchyma. A histologic analysis comparing the 3D models with HepG2 cell monolayers and tumor specimens was performed. In the 3D setting, HepG2 cells were viable and formed large cellular aggregates showing different morphotypes with zonal distribution. Furthermore, β-actin and α5β1 integrin revealed a morphotype-related expression; in particular, the frontline cells were characterized by a strong immunopositivity on a side border of their membrane, thus suggesting the formation of lamellipodia-like structures apt for migration. Based on these results, we propose PVA/G hydrogels as valuable substrates to develop a long term 3D HCC model that can be used to investigate important aspects of tumor biology related to migration phenomena
Cellular distribution of RhoA in human embryonic and adult renal tissues and renal cell lines: morphofunctional implications.
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