1,720,955 research outputs found
Cloning and Vulnerability of Intrinsically Resistant Subset of Ovarian Cancer Stem Cells
No full textThe long-term goal of our research is to identify treatment paradigms that will overcome chemo-therapy resistance in ovarian cancer by understanding the molecular basis of such resistance. High-grade ovarian cancer (HGOC) is highly sensitive to chemotherapy as many patients achieve clinical complete remissions following surgery and a combination of platinum and paclitaxel. However, the vast majority of HGOC patients succumb to recurrent disease that occurs 12-24 months after treatment, usually arising from chemotherapy-resistant tumor cells. Thus there is an urgent need to understand these resistant cells, how they arise, how they evade chemotherapy, and most importantly, how to exploit their vulnerabilities in order to discover and develop drugs that will eradicate them. Innovative new stem cell cloning methods developed in our laboratory now enable - for the first time ever - production of large "libraries" of tumor stem cell clones that will allow us to directly address these issues in HGOC. Our hypothesis is that the HGOC tumor cell libraries we have generated are comprised of the elusive "cancer stem cell (CSC)" or tumor-initiating cells whose intrinsic heterogeneity enables emergence of resistant cells following chemotherapy. If this hypothesis proves valid, we then will be able to isolate these resistant variants from patient samples for both molecular analyses and drug screening, all in a time-frame before the onset of recurrent disease in HGOC patients. [This project was completed with the contributions from Yusuke Yamamoto from the National Cancer Center Research Institute, Amir Jazaeri and Giulio Draetta from The University of Texas MD Anderson Cancer Center, Peter Davies from Texas A&M University, Suzy Torti and Molly Brewer from the University of Connecticut Health Center, Matthew Anderson from Baylor College of Medicine, Christopher Crum from Harvard Medical School and Brigham and Women's Hospital, and Wa Xian and Frank McKeon from The University of Texas McGovern Medical School.]Biology and Biochemistry, Department ofHonors Colleg
The Impact of the Political Climate on Reproductive Health Perceptions in Texas: A Survey-Based Analysis
No full textThis project explores how the shifting political climate in Texas affects public perceptions and personal experiences related to reproductive healthcare. Through a community-focused survey, we examine awareness of current reproductive laws, concerns about access, and attitudes toward government involvement in reproductive decisions. Special attention is given to how factors such as age, gender, and sexual orientation shape individual perspectives and healthcare choices.
By engaging with diverse communities across Houston, particularly those directly impacted by policy changes, this study seeks to better understand how restrictive laws influence personal decision-making, emotional well-being, and advocacy interest. The findings contribute to ongoing national conversations about reproductive rights, access to care, and the broader role of policy in shaping health outcomes. This research underscores the importance of inclusive public health strategies and highlights the need for further engagement and education on reproductive justice issues.Health and Human Performanc
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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